Multidrug resistance genes, p-glycoprotein and the liver

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Mechanism of multidrug resistance

1988 • 630 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Progress in Liver Disease.

1976 • 572 citations

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1989 • 570 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

1979 • 454 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

The liver cell

1960 • 329 citations

Gene Amplification and Drug Resistance in Cultured Murine Cells

1978 • 317 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

1987 • 289 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Multidrug Resistance in Cancer

1989 • 258 citations

Use of fluorescent dyes as molecular probes for the study of multidrug resistance

1988 • 249 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Cloning and Expression of a cDNA Coding for a Rat Liver Plasma Membrane Ecto-ATPase

1989 • 240 citations

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance.

1989 • 233 citations

Mechanism of cross-resistance between vincristine and daunorubicin in Ehrlich ascites tumor cells.

1978 • 231 citations

Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia.

1990 • 229 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

Taurocholate Transport by Rat Liver Sinusoidal Membrane Vesicles: Evidence of Sodium Cotransport

2007 • 210 citations

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

1988 • 205 citations

Rat liver canalicular membrane vesicles. Isolation and topological characterization.

1983 • 202 citations

Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.

1987 • 196 citations

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.

1988 • 176 citations

Potentiation of drug effect by Tween 80 in Chinese hamster cells resistant to actinomycin D and daunomycin.

1972 • 157 citations

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

1987 • 156 citations

Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia

1987 • 140 citations

Taurocholate transport by rat liver canalicular membrane vesicles. Evidence for the presence of an Na+-independent transport system.

1984 • 119 citations

Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells.

1981 • 114 citations

Localization of multidrug resistance-associated DNA sequences to human chromosome 7

1986 • 88 citations

Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein

1989 • 86 citations

Two Ca2+-dependent ATPases in rat liver plasma membrane. The previously purified (Ca2+-Mg2+)-ATPase is not a Ca2+-pump but an ecto-ATPase.

1988 • 83 citations

The Mechanism of Biliary Secretion of Reduced Glutathione

1983 • 74 citations

Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene.

1989 • 62 citations

The transport of bilirubin in the liver.

1961 • 8 citations