Structural and functional analysis of the mouse mdr1b gene promoter

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

The ovalbumin gene - sequence of putative control regions

1980 • 996 citations

Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen

1987 • 969 citations

[12] Unidirectional digestion with exonuclease III in DNA sequence analysis

1987 • 898 citations

Expression cloning of the murine erythropoietin receptor

1989 • 776 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

1987 • 289 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Functionally Differentiated Cell Lines

1982 • 213 citations

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1987 • 198 citations

Coinduction of MDR-1 Multidrug-Resistance and Cytochrome P-450 Genes in Rat Liver by Xenobiotics

1988 • 174 citations

Multidrug Resistance

1989 • 166 citations

A phosphoglycoprotein associated with taxol resistance in J774.2 cells.

1985 • 158 citations

P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines.

1989 • 144 citations

Glucocorticoid- and progesterone-specific effects are determined by differential expression of the respective hormone receptors

1989 • 129 citations

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

1990 • 126 citations

Structure and expression of the rat c-jun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis.

1989 • 121 citations

Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection.

1988 • 107 citations

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

1990 • 103 citations

Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines.

1988 • 99 citations

Differentiation-responsive elements in the 5' region of the mouse tissue plasminogen activator gene confer two-stage regulation by retinoic acid and cyclic AMP in teratocarcinoma cells.

1989 • 94 citations

Negative regulation of transcription in vitro by a glucocorticoid response element is mediated by a trans-acting factor.

1988 • 67 citations

Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene.

1989 • 62 citations

Target sites for the transposition of rat long interspersed repeated DNA elements (LINEs) are not random

1986 • 45 citations

Pleiotropic drug resistance in hepatocytes induced by carcinogens administered to rats.

1987 • 44 citations

Alternate Overexpression of Two Phosphoglycoprotein Genes Is Associated with Changes in Multidrug Resistance in a J774.2 Cell Line

1989 • 42 citations

Molecular evolution of the mouse proline-rich protein multigene family. Insertion of a long interspersed repeated DNA element.

1988 • 39 citations

5′ Structural motifs and Xenopus β globin gene activation

1988 • 6 citations