A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

2013 • 2,504 citations

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

1984 • 2,234 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

BACTERIAL PERIPLASMIC TRANSPORT SYSTEMS: STRUCTURE, MECHANISM, AND EVOLUTION

1986 • 690 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum

1990 • 594 citations

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1989 • 570 citations

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.

1989 • 443 citations

Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing

1990 • 438 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

1990 • 386 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1986 • 255 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

1988 • 205 citations

Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine

1989 • 196 citations

ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells.

1988 • 143 citations

Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies

1989 • 135 citations

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

1990 • 126 citations

Differential transport properties of two mdr gene products are distinguished by progesterone.

1990 • 103 citations

Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA.

1989 • 97 citations

Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes.

1991 • 77 citations

Two Members of the Mouse mdr Gene Family Confer Multidrug Resistance with Overlapping but Distinct Drug Specificities

1990 • 69 citations

Binding of an optically pure photoaffinity analogue of verapamil, LU-49888, to P-glycoprotein from multidrug-resistant human leukemic cell lines.

1990 • 63 citations

Cloning and Characterization of a Second Member of the Mouse mdr Gene Family

1988 • 45 citations

Structural Analysis of the Mouse mdr1a (P-Glycoprotein) Promoter Reveals the Basis for Differential Transcript Heterogeneity in Multidrug-Resistant J774.2 Cells

1990 • 19 citations

Functional Analysis of Chimeric Genes Obtained by Exchanging Homologous Domains of the Mouse mdr1 and mdr2 Genes

1991 • 9 citations