Lysosomotropic agents reverse multiple drug resistance in human cancer cells

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

1979 • 454 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.

1984 • 231 citations

Uptake and retention of adriamycin and daunorubicin by sensitive and anthracycline-resistant sublines of P388 leukemia

1978 • 212 citations

Anthracycline resistance in P388 murine leukemia and its circumvention by calcium antagonists.

1985 • 149 citations

Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate.

1984 • 79 citations

Circumvention of Multiple-Drug Resistance in Human Cancer Cells By Thioridazine, Trifluoperazine, and Chlorpromazine<xref ref-type="fn" rid="FN1">2</xref>

1986 • 70 citations

Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein.

1985 • 58 citations

Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with pseudomonas exotoxin

1984 • 57 citations

Potentiation of cytotoxic activity of immunotoxins on cultured human cells.

1985 • 46 citations

The effects of lysosomotropic amines on protein degradation, migration of nonhistone proteins to the nucleus, and cathepsin D in lymphocytes

1985 • 31 citations

Thioridazine enhances lysosomal accumulation of epidermal growth factor and toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin

1986 • 27 citations

The effect of calcium antagonists on the proteolytic degradation of low-density lipoprotein in HeLa cells

1985 • 19 citations