Structure and expression of the human MDR (P-glycoprotein) gene family.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

1986 • 1,863 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric Field

1986 • 920 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

1986 • 753 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1986 • 410 citations

Rapid and easy sequencing of large linear double-stranded DNA and supercoiled plasmid DNA

1985 • 410 citations

The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

1987 • 384 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit.

1987 • 320 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

1987 • 289 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

1986 • 226 citations

Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA.

1985 • 210 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

Genes amplified and overexpressed in human multidrug-resistant cell lines.

1988 • 170 citations

Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr1 Gene

1986 • 161 citations

mRNA phenotyping by enzymatic amplification of randomly primed cDNA

1988 • 144 citations

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.

1986 • 113 citations

[35] Strategies for mapping and cloning macroregions of mammalian genomes

1987 • 112 citations

Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells.

1987 • 84 citations

Molecular mechanism of multidrug resistance in tumor cells.

1987 • 66 citations

The tissue dependent expression of hamster P‐glycoprotein genes

1988 • 42 citations

Identification of Members of the P-Glycoprotein Multigene Family

1989 • 41 citations

Cloning and characterization of DNA sequences amplified in multidrug-resistant Djungarian hamster and mouse cells

1987 • 26 citations

Separation of large DNA molecules by modified pulsed field gradient gel electrophoresis

1986 • 26 citations

Acquisition of multiple drug resistance by CCRF-CEM cells selected for different degrees of resistance to vincristine.

1984 • 25 citations

Simultaneous Expression of Two P-Glycoprotein Genes in Drug-Sensitive Chinese Hamster Ovary Cells

1987 • 21 citations