Pseudomonas Exotoxin Conjugated to Monoclonal Antibody MRK16 Specifically Kills Multidrug Resistant Cells in Cultured Renal Carcinomas and In Mdr-Transgenic Mice

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

RECOMBINANT TOXINS AS NOVEL THERAPEUTIC AGENTS

1992 • 325 citations

Recombinant Toxins for Cancer Treatment

1991 • 308 citations

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1987 • 225 citations

Targeted Toxin Therapy for the Treatment of Cancer

1989 • 158 citations

Transgenic mice that express the human multidrug-resistance gene in bone marrow enable a rapid identification of agents that reverse drug resistance.

1991 • 152 citations

Expression of a Human Multidrug Resistance cDNA (MDR1) in the Bone Marrow of Transgenic Mice: Resistance to Daunomycin-Induced Leukopenia

1989 • 151 citations

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

1987 • 147 citations

Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain.

1988 • 147 citations

Measurement of Multidrug-Resistance Messenger RNA in Urogenital Cancers; Elevated Expression in Renal Cell Carcinoma is Associated with Intrinsic Drug Resistance

1988 • 124 citations

How protein toxins enter and kill cells

1988 • 122 citations

Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia.

1989 • 112 citations

Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice

1992 • 98 citations

Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40).

1991 • 66 citations

Epidermal Growth Factor in the Normal and Neoplastic Kidney and Bladder

1988 • 60 citations

Mechanisms and Modulation of Multidrug Resistance in Primary Human Renal Cell Carcinoma

1990 • 57 citations

Molecular manipulations of the multidrug transporter: a new role for transgenic mice ¹

1991 • 51 citations

Multidrug resistant transgenic mice as a novel pharmacologic tool

1991 • 23 citations

Antitumor activity of a thioether-linked immunotoxin: OVB3-PE

1990 • 22 citations

Pseudomonas exotoxin — Immunotoxins

1988 • 20 citations