Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

1990 • 736 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

P‐glycoprotein: multidrug‐resistance and a superfamily of membrane‐associated transport proteins

1989 • 512 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

1987 • 425 citations

Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

1985 • 410 citations

Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity

1991 • 407 citations

Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.

1983 • 384 citations

MDR1 Gene Expression and Treatment Outcome in Acute Myeloid Leukemia

1991 • 372 citations

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

1990 • 360 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein.

1989 • 242 citations

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues

1990 • 240 citations

Prediction of Doxorubicin Resistance In Vitro in Myeloma, Lymphoma, and Breast Cancer by P-Glycoprotein Staining

1989 • 202 citations

MDR₁ transcript levels as an indication of resistant disease in acute myelogenous leukaemia

1990 • 184 citations

FK-506 — How much potential?

1989 • 181 citations

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line

1991 • 156 citations

Expression of the multidrug resistance, MDR1, gene in neuroblastomas.

1990 • 132 citations

The Biochemistry Of P-Glycoprotein-Mediated Multidrug Resistance

1989 • 132 citations

Clinical modulation of doxorubicin resistance by the calmodulin-inhibitor, trifluoperazine: a phase I/II trial.

1988 • 124 citations

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

1990 • 123 citations

Expression of a human multidrug resistance gene in ovarian carcinomas.

1989 • 115 citations

Correlation of MDR1 Gene Expression With Chemotherapy in Neuroblastoma

1989 • 112 citations

Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein.

1990 • 108 citations

Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors.

1989 • 104 citations

CYCLOSPORINE, FK506, AND RAPAMYCIN

1990 • 97 citations

Monoclonal antibody to an external epitope of the human mdr1 P-glycoprotein.

1993 • 93 citations

Reversal of drug‐resistance by cyclosporin‐A in a patient with acute myelocytic leukaemia

1990 • 89 citations

Chloroquine enhancement of anticancer drug cytotoxicity in multiple drug resistant human leukemic cells

1986 • 85 citations

High-level, unstable adriamycin resistance in a Chinese hamster mutant cell line with double minute chromosomes.

1984 • 67 citations

A pilot study of quinidine and epirubicin in the treatment of advanced breast cancer

1990 • 66 citations

Enhanced efflux of [3H]vinblastine from Chinese hamster ovary cells transfected with a full-length complementary DNA clone for the mdr1 gene.

1989 • 64 citations

Reversal of multidrug resistance by an immunosuppressive agent FK-506

1992 • 63 citations

Enhancement of anthracycline growth inhibition in parent and multidrug-resistant Chinese hamster ovary cells by cyclosporin A and its analogues.

1989 • 50 citations

Properties of verapamil-hypersensitive multidrug-resistant Chinese hamster ovary cells.

1988 • 46 citations

Treatment of children with refractory acute lymphocytic leukemia with vincristine and diltiazem

1985 • 39 citations

Modulation of drug resistance in a daunorubicin resistant subline with oligonucleoside methylphosphonates.

1989 • 34 citations