Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Genomic sequencing.

1984 • 8,343 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Mechanism of multidrug resistance

1988 • 630 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

Arabinosyl Cytosine: A Useful Agent in the Treatment of Acute Leukemia in Adults

1968 • 559 citations

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

1984 • 521 citations

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

1987 • 425 citations

Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

1985 • 410 citations

Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.

1986 • 321 citations

Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 • 296 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

P-glycoprotein in human sarcoma: evidence for multidrug resistance.

1987 • 261 citations

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1987 • 225 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Prediction of Doxorubicin Resistance In Vitro in Myeloma, Lymphoma, and Breast Cancer by P-Glycoprotein Staining

1989 • 202 citations

Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia

1989 • 151 citations

Failure of remission induction in acute myelocytic leukemia

1978 • 148 citations

Expression of the multidrug resistance gene in myeloid leukemias

1990 • 124 citations

Mapping of transcription initiation and termination signals on Xenopus laevis ribosomal DNA.

1982 • 110 citations

Development and characterization of a human sarcoma cell line, MES-SA, sensitive to multiple drugs.

1983 • 96 citations

Increased P-glycoprotein expression and multidrug-resistant gene (mdr1) amplification are infrequently found in fresh acute leukemia cells. Sequential analysis of 15 cases at initial presentation and relapsed stage

1989 • 88 citations

Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.

1987 • 72 citations

Multidrug-Resistance in Human Cancer

1989 • 64 citations

Dissociation of Antitumor Potency from Anthracycline Cardiotoxicity in a Doxorubicin Analog

1985 • 49 citations

Multivariate analysis of prognostic factors in acute myeloid leukemia: value of clonogenic leukemic cell properties.

1989 • 47 citations

Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells

1992 • 45 citations

Expression of a Multidrug Resistance Gene in Blast Crisis of Chronic Myelogenous Leukemia

1989 • 44 citations

Multidrug resistance in human cancer

1994 • 37 citations

Prognostic value of clonogenic assay for induction and duration of complete remission in acute myelogenous leukemia.

1987 • 16 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 11 citations

Interactions of adriamycin in sensitive and resistant leukemic cells: A comparative study by microspectrofluorometry.

1984 • 9 citations

Prognostic value of clonogenic assay for induction and duration of complete remission in acute myelogenous leukemia.

1987 • 9 citations

Effect of schedule and combinations on clinical effectiveness of Ara-C in adult acute leukemia

1982 • 7 citations