Overexpression of multidrug resistance‐associated p170‐glycoprotein in acute non‐lymphocytic leukemia

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

1984 • 3,268 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

Multidrug Resistance1

1988 • 321 citations

Pleiotropic phenotype of colchicine‐resistant CHO cells: Cross‐resistance and collateral sensitivity

1976 • 314 citations

DETECTION OF A MULTIDRUG RESISTANT PHENOTYPE IN ACUTE NON-LYMPHOBLASTIC LEUKAEMIA

1987 • 223 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Expression of mdr1 and mdr3 Multidrug-resistance Genes in Human Acute and Chronic Leukemias and Association With Stimulation of Drug Accumulation by Cyclosporine

1990 • 210 citations

MDR₁ transcript levels as an indication of resistant disease in acute myelogenous leukaemia

1990 • 184 citations

Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia

1989 • 151 citations

P-glycoprotein and multidrug resistance in cancer chemotherapy.

1989 • 139 citations

Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia

1989 • 135 citations

Drug-induced DNA hypermethylation and drug resistance in human tumors.

1989 • 119 citations

Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin

1986 • 119 citations

Genetics of multidrug resistance.

1988 • 118 citations

Mechanisms of Drug Resistance in Neoplastic Cells

1988 • 114 citations

Unknotting the Complexities of Multidrug Resistance: The Involvement of DNA Topoisomerases in Drug Action and Resistance

1989 • 107 citations

Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors.

1989 • 104 citations

Reversal of drug‐resistance in multiple myeloma with verapamil

1988 • 102 citations

Expression of the multidrug transporter, P‐glycoprotein, in chronic myelogenous leukaemia cells in blast crisis

1990 • 92 citations

Increased P-glycoprotein expression and multidrug-resistant gene (mdr1) amplification are infrequently found in fresh acute leukemia cells. Sequential analysis of 15 cases at initial presentation and relapsed stage

1989 • 88 citations

The frequency of long‐term remission in patients with acute myelogenous leukaemia treated with conventional maintenance chemotherapy: a study of 760 patients with a minimal follow‐up time of 6 years

1989 • 77 citations

Therapy of acute myelogenous leukemia.

1987 • 77 citations

Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells.

1987 • 72 citations

Elimination of chemoresistant multiple myeloma clonogenic colony-forming cells by combined treatment with a plasma cell-reactive monoclonal antibody and a P-glycoprotein-reactive monoclonal antibody.

1989 • 25 citations

In vitro bone marrow purging of multidrug-resistant cells with a mouse monoclonal antibody directed against Mr 170,000 glycoprotein and a saporin-conjugated anti-mouse antibody.

1990 • 24 citations

Clinical Relevance of Immunocytochemical Detection of Multidrug-Resistance-Associated P-Glycoprotein in Hematologic Malignancies

1990 • 24 citations

Gene amplification and altered enzymes as mechanisms for the development of drug resistance.

1983 • 15 citations

Multidrug resistance: Drug extrusion and its counteraction by chemosensitizers

1989 • 7 citations