Structure and Evolution of P-Glycoproteins

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

1984 • 2,234 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

1986 • 753 citations

Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure

1989 • 745 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

BACTERIAL PERIPLASMIC TRANSPORT SYSTEMS: STRUCTURE, MECHANISM, AND EVOLUTION

1986 • 690 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Nucleotide sequence of an Escherichia coli chromosomal hemolysin

1985 • 572 citations

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1989 • 570 citations

Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil

1987 • 558 citations

Efflux of Chloroquine from Plasmodium falciparum : Mechanism of Chloroquine Resistance

1987 • 523 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Amplification of a Gene Related to Mammalian mdr Genes in Drug-Resistant Plasmodium falciparum

1989 • 439 citations

Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis.

1988 • 436 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1986 • 410 citations

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.

1988 • 373 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Intron‐dependent evolution: Preferred types of exons and introns

1987 • 300 citations

Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 • 296 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

DNA sequence of the white locus of Drosophila melanogaster

1984 • 282 citations

Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.

1990 • 271 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Splice Junctions: Association with Variation in Protein Structure

1983 • 261 citations

Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus

1982 • 256 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Cloning, nucleotide sequence, and characterization of genes encoding the secretion function of the Pasteurella haemolytica leukotoxin determinant

1989 • 239 citations

The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes.

1988 • 224 citations

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

1988 • 205 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

Multidrug-resistance phenotype in Chinese hamster ovary cells.

1983 • 194 citations

Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins

1986 • 187 citations

Bovine opsin has more than one signal sequence

1985 • 186 citations

Insertion of a multispanning membrane protein occurs sequentially and requires only one signal sequence

1988 • 185 citations

The ndvA gene product of Rhizobium meliloti is required for beta-(1----2)glucan production and has homology to the ATP-binding export protein HlyB

1988 • 165 citations

Cloning and complete nucleotide sequence of the Escherichia coli glutamine permease operon (glnHPQ)

1986 • 161 citations

Genetic evidence for substrate and periplasmic-binding-protein recognition by the MalF and MalG proteins, cytoplasmic membrane components of the Escherichia coli maltose transport system

1985 • 152 citations

Do exons code for structural or functional units in proteins?

1988 • 147 citations

Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells.

1987 • 84 citations

Cloning and nucleotide sequence of the chlD locus

1987 • 79 citations

Structure and mechanism of bacterial periplasmic transport systems

1988 • 51 citations