Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

DNA topoisomerase II is required at the time of mitosis in yeast

1985 • 747 citations

Cleavage of DNA by mammalian DNA topoisomerase II.

1983 • 539 citations

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.

1984 • 463 citations

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

1987 • 426 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

1988 • 391 citations

Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.

1981 • 350 citations

Recent studies of DNA topoisomerases

1987 • 323 citations

Characterization and properties of nine human ovarian adenocarcinoma cell lines.

1988 • 247 citations

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide

1989 • 228 citations

DNA Topoisomerases as Anticancer Drug Targets

1990 • 195 citations

Characterization of an Amsacrine-resistant Line of Human Leukemia Cells

1989 • 179 citations

Nonproductive Rearrangement of DNA Topoisomerase I and II Genes: Correlation With Resistance to Topoisomerase Inhibitors

1989 • 172 citations

Proliferation dependence of topoisomerase II-mediated drug action

1986 • 170 citations

Nuclear topoisomerase II levels correlate with the sensitivity of mammalian cells to intercalating agents and epipodophyllotoxins.

1988 • 166 citations

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide.

1991 • 163 citations

Decatenation of kinetoplast DNA by topoisomerases.

1980 • 159 citations

Combined modalities of resistance in etoposide-resistant human KB cell lines.

1988 • 146 citations

Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line

1989 • 89 citations

Mature mRNA is selectively released from the nuclear matrix by an ATP/dATP-dependent mechanism sensitive to topoisomerase inhibitors.

1987 • 73 citations

DNA breakage in human lung carcinoma cells and nuclei that are naturally sensitive or resistant to etoposide and teniposide

1987 • 73 citations

Sister chromatid exchanges, chromosomal aberrations, and cytotoxicity produced by antitumor topoisomerase II inhibitors in sensitive (DC3F) and resistant (DC3F/9-OHE) Chinese hamster cells.

1988 • 72 citations

Genetic, biochemical, and cross-resistance studies with mutants of Chinese hamster ovary cells resistant to the anticancer drugs, VM-26 and VP16-213.

1983 • 68 citations

Depletion of topoisomerase II in isolated nuclei during a glucose-regulated stress response.

1989 • 57 citations

Reduced DNA topoisomerase II activity and drug-stimulated DNA cleavage in 9-hydroxyellipticine resistant cells

1988 • 49 citations

Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.

1989 • 47 citations

Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants.

1989 • 45 citations

Assembly of transcriptionally active chromatin in vitro: a possible role for topoisomerase II.

1990 • 10 citations

Reduced formation of lesions in the DNA of a multidrug-resistant L1210 subline selected for teniposide resistance

1989 • 6 citations