Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.

1984 • 231 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

Neutral amino acid transport systems in Chinese hamster ovary cells.

1981 • 194 citations

Circumvention of Multiple-Drug Resistance in Human Cancer Cells By Thioridazine, Trifluoperazine, and Chlorpromazine<xref ref-type="fn" rid="FN1">2</xref>

1986 • 70 citations