Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Rapid similarity searches of nucleic acid and protein data banks.

1983 • 1,577 citations

[47] Establishing homologies in protein sequences

1983 • 1,187 citations

Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

1985 • 1,126 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Automation of the computer handling of gel reading data produced by the shotgun method of DNA sequencing

1982 • 744 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Nucleotide sequence of an Escherichia coli chromosomal hemolysin

1985 • 572 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Enhanced graphic matrix analysis of nucleic acid and protein sequences.

1981 • 476 citations

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

1979 • 454 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Selection of initiation sites by eucaryotic ribosomes: effect of inserting AUG triplets upstream from the coding sequence for preproinsulin

1984 • 390 citations

Murine B Cell Leukemia Line with Inducible Surface Immunoglobulin Expression

1978 • 388 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium

1982 • 322 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Transport of hemolysin across the outer membrane of Escherichia coli requires two functions

1983 • 255 citations

Mechanism of cross-resistance between vincristine and daunorubicin in Ehrlich ascites tumor cells.

1978 • 231 citations

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

1986 • 226 citations

Nucleotide binding by membrane components of bacterial periplasmic binding protein-dependent transport systems.

1985 • 219 citations

Phosphate-specific transport system of Escherichia coli: nucleotide sequence and gene-polypeptide relationships

1985 • 219 citations

Folding patterns of porin and bacteriorhodopsin.

1985 • 206 citations

Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins

1986 • 187 citations

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

1985 • 176 citations

Sequence of themalKgene inE.coliK12

1982 • 157 citations

A model of evolutionary change in protein

1978 • 138 citations

Sequences of Escherichia coli uvrA gene and protein reveal two potential ATP binding sites.

1986 • 137 citations

Isolation and characterization of an anthracycline-resistant human leukemic cell line.

1985 • 137 citations

ATP-binding sites in the membrane components of histidine permease, a periplasmic transport system.

1984 • 137 citations

Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells.

1981 • 114 citations

Drug resistance in Chinese hamster lung and mouse tumor cells.

1983 • 105 citations

Genetic characterization and molecular cloning of the tripeptide permease (tpp) genes of Salmonella typhimurium

1984 • 74 citations

High-level, unstable adriamycin resistance in a Chinese hamster mutant cell line with double minute chromosomes.

1984 • 67 citations

Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein.

1985 • 58 citations

Unresolved issues in combination chemotherapy.

1986 • 39 citations

Comparison of adriamycin uptake in chick embryo heart and liver cells an murine L5178Y lymphoblasts in vitro: role of drug uptake in cardiotoxicity.

1986 • 38 citations

Chromosome-Mediated Gene Transfer of Multidrug Resistance

1986 • 36 citations

The organization, mechanism of action, and evolution of periplasmic transport systems

1983 • 36 citations

Chromosome-mediated gene transfer of multidrug resistance.

1986 • 31 citations

Correlation of unstable multidrug cross resistance in Chinese hamster ovary cells with a homogeneously staining region on chromosome 1.

1983 • 30 citations

Calmodulin and alpha tocopherol as additional binding sites for doxorubicin

1986 • 6 citations