Molecular and Cytogenetic Analysis of Multidrug Resistance-Associated Gene Amplification in Chinese Hamster, Mouse Sarcoma, and Human Neuroblastoma Cells

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

1973 • 1,284 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Transposition and amplification of oncogene-related sequences in human neuroblastomas

1983 • 711 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

GENE AMPLIFICATION

1984 • 580 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

1976 • 396 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

DOUBLE MINUTES AND HOMOGENEOUSLY STAINING REGIONS: Gene Amplification in Mammalian Cells

1982 • 357 citations

Oncogene Amplification in Tumor Cells

1986 • 353 citations

Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells.

1987 • 296 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Double minute chromosomes can be produced from precursors derived from a chromosomal deletion.

1988 • 236 citations

Uptake and retention of adriamycin and daunorubicin by sensitive and anthracycline-resistant sublines of P388 leukemia

1978 • 212 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

DNA Sequence Amplification in Mammalian Cells

1984 • 181 citations

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

1987 • 179 citations

Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes

1983 • 178 citations

Uptake and retention of daunomycin by mouse leukemic cells as factors in drug response.

1968 • 171 citations

Genes amplified and overexpressed in human multidrug-resistant cell lines.

1988 • 170 citations

Association of amplified oncogene c-myc with an abnormally banded chromosome 8 in a human leukaemia cell line

1983 • 152 citations

Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine.

1983 • 146 citations

A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.

1986 • 137 citations

Phosphorylation of the multidrug resistance associated glycoprotein

1987 • 131 citations

Increased synthesis of a low molecular weight protein in vincristine-resistant cells

1981 • 121 citations

Differential protooncogene expression characterizes histopathologically indistinguishable tumors of the peripheral nervous system.

1987 • 117 citations

Cross resistance between vinca alkaloids and anthracyclines in Ehrlich ascites tumor in vivo.

1972 • 115 citations

Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells.

1981 • 114 citations

Cellular resistance to daunomycin in Chinese hamster cells in vitro.

1971 • 113 citations

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.

1986 • 113 citations

Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins.

1987 • 110 citations

Membrane-Mediated Drug Resistance and Phenotypic Reversion to Normal Growth Behavior of Chinese Hamster Cells 2

1975 • 106 citations

Drug resistance in Chinese hamster lung and mouse tumor cells.

1983 • 105 citations

Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.

1985 • 100 citations

Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases.

1980 • 100 citations

Localization of multidrug resistance-associated DNA sequences to human chromosome 7

1986 • 88 citations

Specifically altered metaphase chromosomes in antifolate-resistant Chinese hamster cells that overproduce dihydrofolate reductase

1980 • 88 citations

Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells.

1987 • 84 citations

Neurotransmitter-synthesizing enzymes in 14 human neuroblastoma cell lines

1981 • 84 citations

Alterations in cell surface membranes in chinese hamster lung cells resistant to adriamycin

1982 • 84 citations

Specific DNA sequence amplification in human neuroblastoma cells.

1983 • 72 citations

Uptake and binding of vincristine by murine leukemia cells

1975 • 71 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 66 citations

Plasma membrane proteins and glycoproteins from chinese hamster cells sensitive and resistant to actinomycin D

1978 • 66 citations

Incorporation of Tritiated Actinomycin D into Drug-Sensitive and Drug-Resistant HeLa Cells

1966 • 63 citations

Sorcin (V19), a soluble acidic calcium-binding protein overproduced in multidrug-resistant cells

1987 • 60 citations

Homogeneously Staining Regions and Double Minute Chromosomes, Prevalent Cytogenetic Abnormalities of Human Neuroblastoma Cells

1983 • 52 citations

General Method for Cloning Amplified DNA by Differential Screening with Genomic Probes

1982 • 47 citations

Expression of a P-glycoprotein gene is inducible in a multidrug resistant human leukemia cell line

1988 • 47 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 45 citations

Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines.

1982 • 43 citations

Chromosomal location of human P-glycoprotein gene sequences

1987 • 43 citations

Specific karyotypic alterations in colchicine-resistant cells

1981 • 42 citations

Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster cells.

1988 • 41 citations

Expression of the amplified domain in human neuroblastoma cells.

1984 • 41 citations

SOME BIOCHEMICAL PROPERTIES OF CHINESE HAMSTER CELLS SENSITIVE AND RESISTANT TO ACTINOMYCIN D

1974 • 39 citations

Chromosomal localization of three genes coamplified in the multidrug-resistant CHRC5 Chinese hamster ovary cell line.

1987 • 38 citations

Gene amplification accompanies low level increases in the activity of dihydrofolate reductase in antifolate-resistant Chinese hamster lung cells containing abnormally banding chromosomes.

1982 • 33 citations

General method for cloning amplified DNA by differential screening with genomic probes.

1982 • 27 citations

Cellular Concomitants of Multidrug Resistance

1988 • 19 citations

Actinomycin‐D‐resistant in vitro mouse cell line derived from a methylcholanthrene‐induced sarcoma: Decrease of malignancy and antigenic characteristics

1974 • 17 citations

Nucleotide sequence of the 3′ exon of the human N-myc gene

1985 • 12 citations

Abnormally banded chromosomal regions in doxorubicin-resistant B16-BL6 murine melanoma cells.

1986 • 11 citations

Localization of Chinese hamster dihydrofolate reductase gene to band p23 of chromosome 2

1986 • 10 citations

Assignment of the native Chinese hamster dihydrofolate reductase gene to chromosome 2

1983 • 6 citations

[Relation of mammalian cell resistance to actinomycin D with a change in the karyotype and a decrease in cytoplasmic membrane permeability].

1981 • 5 citations

Reduced tumorigenicity of syngeneic mouse sarcoma cells resistant to actinomycin d and ethidium bromide. Abstr.

1973 • 2 citations