The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

Molecular Actions and Targets for Cancer Chemotherapeutic Agents

1981 • 361 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

1986 • 226 citations

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

1985 • 176 citations

Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr1 Gene

1986 • 161 citations

Isolation and characterization of adriamycin-resistant HL-60 cells which are not defective in the initial intracellular accumulation of drug.

1986 • 117 citations

Structure of the promoter for chicken alpha 2 type I collagen gene.

1981 • 92 citations

Comparison of anthracycline concentrations in S180 cell lines of varying sensitivity

1983 • 44 citations

Transcription of the chicken alpha 2 (Type I) collagen gene by homologous cell-free extracts.

1982 • 22 citations