P-glycoproteins in pathology: The multidrug resistance gene family in humans

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Survival strategies of bacteria in the natural environment

1987 • 1,627 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Survival strategies of bacteria in the natural environment.

1987 • 773 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

1986 • 753 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Mechanism of multidrug resistance

1988 • 630 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1989 • 570 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Cortical Flow in Animal Cells

1988 • 554 citations

Efflux of Chloroquine from Plasmodium falciparum : Mechanism of Chloroquine Resistance

1987 • 523 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

1979 • 454 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Amplification of a Gene Related to Mammalian mdr Genes in Drug-Resistant Plasmodium falciparum

1989 • 439 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

1987 • 425 citations

Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

1985 • 410 citations

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1986 • 410 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

1979 • 368 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

The cell biology of multiple drug resistance

1987 • 340 citations

Multidrug Resistance1

1988 • 321 citations

Gene Amplification and Drug Resistance in Cultured Murine Cells

1978 • 317 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

1986 • 301 citations

Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 • 296 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells

1991 • 281 citations

Monoclonal antibody JSB‐1 detects a highly conserved epitope on the P‐glycoprotein associated with multi‐drug‐resistance

1988 • 278 citations

Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.

1986 • 275 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

P-glycoprotein in human sarcoma: evidence for multidrug resistance.

1987 • 261 citations

MECHANISMS OF MULTIDRUG RESISTANCE AND IMPLICATIONS FOR THERAPY

1988 • 230 citations

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1987 • 225 citations

DETECTION OF A MULTIDRUG RESISTANT PHENOTYPE IN ACUTE NON-LYMPHOBLASTIC LEUKAEMIA

1987 • 223 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Freeze Fracture: Methods, Artifacts, and Interpretations

1979 • 210 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

Optical microscope system for standardized cell measurements and analyses

1987 • 181 citations

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

1987 • 179 citations

Coinduction of MDR-1 Multidrug-Resistance and Cytochrome P-450 Genes in Rat Liver by Xenobiotics

1988 • 174 citations

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 173 citations

Uptake and retention of daunomycin by mouse leukemic cells as factors in drug response.

1968 • 171 citations

Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr1 Gene

1986 • 161 citations

STRUCTURAL ASPECTS OF THE RED CELL ANION EXCHANGE PROTEIN

1986 • 159 citations

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

1987 • 156 citations

Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia

1989 • 151 citations

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

1987 • 147 citations

Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression.

1989 • 140 citations

P-glycoprotein and multidrug resistance in cancer chemotherapy.

1989 • 139 citations

Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL-60 cells.

1989 • 132 citations

Isolation and Characterization of Ultramicrobacteria from a Gulf Coast Estuary

1982 • 128 citations

Clinical modulation of doxorubicin resistance by the calmodulin-inhibitor, trifluoperazine: a phase I/II trial.

1988 • 124 citations

Measurement of Multidrug-Resistance Messenger RNA in Urogenital Cancers; Elevated Expression in Renal Cell Carcinoma is Associated with Intrinsic Drug Resistance

1988 • 124 citations

Increased synthesis of a low molecular weight protein in vincristine-resistant cells

1981 • 121 citations

Genetics of multidrug resistance.

1988 • 118 citations

MEDICAL ONCOLOGY

1977 • 116 citations

Expression of a human multidrug resistance gene in ovarian carcinomas.

1989 • 115 citations

Multidrug Resistance: Molecular Biology Clinical Relevance

1989 • 114 citations

Mechanisms of Drug Resistance in Neoplastic Cells

1988 • 114 citations

MDR1 RNA Levels in Human Renal Cell Carcinomas: Correlation With Grade and Prediction of Reversal of Doxorubicin Resistance by Quinidine in Tumor Explants

1989 • 114 citations

Biosynthesis of heterogeneous forms of multidrug resistance-associated glycoproteins.

1987 • 110 citations

Membrane-Mediated Drug Resistance and Phenotypic Reversion to Normal Growth Behavior of Chinese Hamster Cells 2

1975 • 106 citations

Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors.

1989 • 104 citations

Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.

1986 • 102 citations

Focal Adhesions and Cell-Matrix Interactions

1988 • 99 citations

Increased P-glycoprotein expression and multidrug-resistant gene (mdr1) amplification are infrequently found in fresh acute leukemia cells. Sequential analysis of 15 cases at initial presentation and relapsed stage

1989 • 88 citations

A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug-resistant human ovarian carcinoma cell lines.

1988 • 77 citations

Molecular mechanism of multidrug resistance in tumor cells.

1987 • 66 citations

Plasma membrane proteins and glycoproteins from chinese hamster cells sensitive and resistant to actinomycin D

1978 • 66 citations

Epidermal growth factor receptor is increased in multidrug-resistant Chinese hamster and mouse tumor cells.

1986 • 65 citations

Expression of hamster P-glycoprotein and multidrug resistance in DNA-mediated transformants of mouse LTA cells.

1987 • 63 citations

Multidrug Resistance: P-glycoprotein and Its Allies--The Elusive Foes

1989 • 61 citations

Sorcin (V19), a soluble acidic calcium-binding protein overproduced in multidrug-resistant cells

1987 • 60 citations

Purification of the Mr 22,000 calcium-binding protein (sorcin) associated with multidrug resistance and its detection with monoclonal antibodies.

1988 • 58 citations

Verapamil Reversal of Clinical Doxorubicin Resistance in Human Cancer A Wilshire Oncology Medical Group Pilot Phase I-II Study

1986 • 56 citations

The tumor dormant state. Comparison of L5178Y cells used to establish dormancy with those that emerge after its termination.

1979 • 54 citations

Altered plasma membrane ultrastructure in multidrug-resistant cells

1988 • 54 citations

The tumor dormant state. Quantitation of L5178Y cells and host immune responses during the establishment and course of dormancy in syngeneic DBA/2 mice.

1979 • 49 citations

Susceptibility of chemoresistant murine and human tumor cells to lysis by interleukin 2-activated lymphocytes.

1988 • 47 citations

Identification of Members of the P-Glycoprotein Multigene Family

1989 • 41 citations

The band 3-rich membrane of llama erythrocytes: Studies on cell shape and the organization of membrane proteins

1983 • 38 citations

Circumvention of resistance to anthracyclines by calcium antagonists and other membrane-perturbing agents.

1986 • 37 citations

Chromosome-Mediated Gene Transfer of Multidrug Resistance

1986 • 36 citations

Treatment of refractory multiple myeloma and considerations for future therapy.

1986 • 32 citations

Chromosome-mediated gene transfer of multidrug resistance.

1986 • 31 citations

Phospholipid and ether linked phospholipid content alter with cellular resistance to vinblastine

1985 • 30 citations

Resistance of multidrug‐resistant lines to natural killer‐like cell‐mediated cytotoxicity

1988 • 30 citations

Freeze-fracture study of plasma membranes in wild type and daunorubicin-resistant Ehrlich ascites tumor and P388 leukemia cells

1988 • 20 citations

Cellular Concomitants of Multidrug Resistance

1988 • 19 citations

Quantitative Estimation of MDR1 mRNA Levels by Polymerase Chain Reaction

1991 • 14 citations

Multidrug resistance in the laboratory and clinic.

1989 • 13 citations

Different Mechanisms of Multiple Drug Resistance in Two Human Leukemic Cell Lines

1988 • 12 citations

Structure and Evolution of P-Glycoproteins

1991 • 12 citations

The multidrug transporter: rapid modulation of efflux activity monitored in single cells by the morphologic effects of vinblastine and daunomycin.

1989 • 11 citations

Contribution of drug transport and reductases to daunorubicin resistance in human myelocytic cells

1986 • 10 citations

Evidence that multidrug resistance in Chinese hamster ovary cells is associated with alterations in the endoplasmic reticulum

1987 • 3 citations