Reduced mRNA levels for the multidrug‐resistance genes in cAMP‐dependent protein kinase mutant cell lines

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

cAMP-DEPENDENT PROTEIN KINASE: FRAMEWORK FOR A DIVERSE FAMILY OF REGULATORY ENZYMES

1990 • 1,121 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Comparison of three actin-coding sequences in the mouse; Evolutionary relationships between the actin genes of warm-blooded vertebrates

1986 • 678 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

Enhanced Transcription of c- myc in Bursal Lymphoma Cells Requires Continuous Protein Synthesis

1985 • 469 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements.

1987 • 409 citations

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells.

1990 • 396 citations

Progesterone Interacts with P-Glycoprotein in Multidrug-resistant Cells and in the Endometrium of Gravid Uterus

1989 • 290 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.

1987 • 248 citations

Regulation of transcription by cyclic AMP-dependent protein kinase.

1989 • 247 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.

1987 • 196 citations

Cyclic AMP stabilizes the mRNA for phosphoenolpyruvate carboxykinase (GTP) against degradation.

1988 • 165 citations

Mutations in cyclic AMP-dependent protein kinase and corticotropin (ACTH)-sensitive adenylate cyclase affect adrenal steroidogenesis.

1979 • 156 citations

Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells.

1990 • 155 citations

Adrenal cells in tissue culture

1968 • 144 citations

Recombinant Fragment of Protein Kinase Inhibitor Blocks Cyclic AMP-Dependent Gene Transcription

1987 • 139 citations

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

1990 • 126 citations

Genetic basis of multidrug resistance of tumor cells

1990 • 124 citations

Differential transport properties of two mdr gene products are distinguished by progesterone.

1990 • 103 citations

Isolation of multiple classes of mutants of CHO cells resistant to cyclic AMP

1980 • 92 citations

Complexities of gene regulation by cAMP

1989 • 83 citations

Progesterone photoaffinity labels P-glycoprotein in multidrug-resistant human leukemic lymphoblasts.

1990 • 80 citations

The roles of cAMP and cAMP-dependent Protein Kinase in the Expression of Cholesterol Side Chain Cleavage and Steroid 11β-Hydroxylase Genes in Mouse Adrenocortical Tumor Cells

1989 • 62 citations

Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter

1990 • 54 citations

Drug resistance in mammalian cells

1989 • 53 citations

Cyclic AMP and phorbol esters interact synergistically to regulate expression of the chorionic gonadotropin genes.

1988 • 52 citations

The role of cAMP in regulating tumour cell growth.

1986 • 46 citations

Transfection of a mutant regulatory subunit gene of cAMP-dependent protein kinase causes increased drug sensitivity and decreased expression of P-glycoprotein

1990 • 45 citations

Notes: Cell-Specific Activity of cis-Acting Regulatory Elements in the Promoter of the Mouse Multidrug Resistance Gene mdr1

1990 • 45 citations

Isolation of mutant adrenocortical tumor cells resistant to cyclic nucleotides

1977 • 42 citations

Genetic approaches to cyclic AMP effects in cultured mammalian cells

1980 • 37 citations

Cyclic AMP-dependent protein kinase regulates sensitivity of cells to multiple drugs.

1987 • 28 citations

Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1.

1990 • 27 citations

cAMP stimulation of Dictyostelium discoideum destabilizes the mRNA for 117 antigen.

1990 • 18 citations

DNA-mediated gene transfer of a mutant regulatory subunit of cAMP-dependent protein kinase.

1985 • 14 citations

Multidrug resistance in the laboratory and clinic.

1989 • 13 citations