Increased P-glycoprotein expression and multidrug-resistant gene (mdr1) amplification are infrequently found in fresh acute leukemia cells. Sequential analysis of 15 cases at initial presentation and relapsed stage

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1986 • 410 citations

Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

1985 • 410 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer.

1981 • 374 citations

Molecular Actions and Targets for Cancer Chemotherapeutic Agents

1981 • 361 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

P-glycoprotein in human sarcoma: evidence for multidrug resistance.

1987 • 261 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1987 • 225 citations

DETECTION OF A MULTIDRUG RESISTANT PHENOTYPE IN ACUTE NON-LYMPHOBLASTIC LEUKAEMIA

1987 • 223 citations

Gene deletions correlate with the development of alloantibodies in von Willebrand disease.

1987 • 170 citations

DNA-mediated transfer and cloning of a human multidrug-resistant gene of adriamycin-resistant myelogenous leukemia K562.

1987 • 70 citations

Co-amplification of double minute chromosomes, multiple drug resistance, and cell surface P-glycoprotein in DNA-mediated transformants of mouse cells.

1984 • 52 citations