Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1986 • 255 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.

1982 • 201 citations

Active amino acid transport in plasma membrane vesicles from Simian virus 40-transformed mouse fibroblasts. Characteristics of electrochemical Na+ gradient-stimulated uptake.

1977 • 132 citations

Effect of bisbenzylisoquinoline (biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells.

1987 • 97 citations

Lysosomotropic agents reverse multiple drug resistance in human cancer cells

1986 • 70 citations

Circumvention of Multiple-Drug Resistance in Human Cancer Cells By Thioridazine, Trifluoperazine, and Chlorpromazine<xref ref-type="fn" rid="FN1">2</xref>

1986 • 70 citations

Differential effect of the calmodulin inhibitor trifluoperazine on cellular accumulation, retention, and cytotoxicity of anthracyclines in doxorubicin (adriamycin)-resistant P388 mouse leukemia cells.

1984 • 63 citations

Effect of bisbenzylisoquinoline (biscoclaurine) alkaloids on multidrug resistance in KB human cancer cells

1988 • 46 citations

Reversal of multidrug resistance by synthetic isoprenoids in the KB human cancer cell line.

1986 • 44 citations

Specific Vinca alkaloid-binding polypeptides identified in calf brain by photoaffinity labeling.

1987 • 31 citations

Overcoming Drug Resistance in Cancer Cells With Synthetic Isoprenoids<xref ref-type="fn" rid="FN1">2</xref>

1986 • 29 citations

Cancer Drug Resistance

2022 • 25 citations

Potentiation of vincristine by vitamin A against drug-resistant mouse leukaemia cells

1987 • 14 citations

Techniques to reverse or circumvent drug-resistance in vitro.

1986 • 4 citations