Decreased nuclear matrix DNA topoisomerase II in human leukemia cells resistant to VM-26 and m-AMSA

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

DNA topoisomerase II is required at the time of mitosis in yeast

1985 • 747 citations

Transcription generates positively and negatively supercoiled domains in the template

1988 • 742 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

1984 • 685 citations

A fixed site of DNA replication in eucaryotic cells

1980 • 669 citations

Mechanism of multidrug resistance

1988 • 630 citations

Supercoiled loops and eucaryotic DNA replication

1980 • 626 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction.

1985 • 472 citations

Topoisomerase II: A specific marker for cell proliferation.

1986 • 434 citations

The cell biology of multiple drug resistance

1987 • 340 citations

The organisation of chromatin loops: characterization of a scaffold attachment site

1986 • 308 citations

Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.

1989 • 263 citations

Novel topologically knotted DNA from bacteriophage P4 capsids: studies with DNA topoisomerases

1981 • 231 citations

Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

1987 • 229 citations

Dynamic association of replicating DNA fragments with the nuclear matrix of regenerating liver

1981 • 229 citations

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26

1988 • 223 citations

Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells.

1987 • 180 citations

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 173 citations

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

1986 • 168 citations

Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity.

1986 • 165 citations

The replication of kinetoplast DNA networks in Crithidia fasciculata

1978 • 148 citations

Combined modalities of resistance in etoposide-resistant human KB cell lines.

1988 • 146 citations

Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression.

1989 • 140 citations

Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate

1989 • 124 citations

DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: implications for the mechanism of action.

1988 • 76 citations

Characterization of a subline of P388 leukemia resistant to amsacrine: evidence of altered topoisomerase II function.

1987 • 73 citations

A quantitative decatenation assay for type II topoisomerases

1986 • 65 citations

Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas.

1987 • 64 citations

Cellular pharmacology of vinca alkaloid resistance and its circumvention

1984 • 61 citations

Reduced DNA topoisomerase II activity and drug-stimulated DNA cleavage in 9-hydroxyellipticine resistant cells

1988 • 49 citations

The interaction between nuclear topoisomerase II activity from human leukemia cells, exogenous DNA, and 4′-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA) or 4-(4,6-0-ethylidene-β-D-glucopyranoside) (VP-16) indicates the sensitivity of the cells to the drugs

1987 • 43 citations

Topoisomerase II-dependent and -independent mechanisms of etoposide resistance in Chinese hamster cell lines.

1989 • 40 citations

Topoisomerase-II-mediated lesions in nascent DNA: Comparison of the effects of epipodophyllotoxin derivatives, VM-26 and VP-16, and 9-anilinoacridine derivatives, m-AMSA and o-AMSA

1988 • 33 citations

Effects of antileukemia agents on nuclear matrix-bound DNA replication in CCRF-CEM leukemia cells.

1988 • 31 citations

Multiple mechanisms of adriamycin resistance in the human leukemia cell line CCRF-CEM

1989 • 25 citations

Comparison of DNA-protein cross-links induced by 4'-(9-acridinylamino)-methanesulfon-m-anisidide and by gamma-radiation.

1989 • 10 citations