Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Prediction of protein antigenic determinants from amino acid sequences.

1981 • 3,715 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Fluorographic detection of radioactivity in polyacrylamide gols with the water-soluble fluor, sodium salicylate

1979 • 1,976 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Yeast/E. coli shuttle vectors with multiple unique restriction sites

1986 • 1,399 citations

Laboratory course manual for methods in yeast genetics

1986 • 1,310 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

BACTERIAL PERIPLASMIC TRANSPORT SYSTEMS: STRUCTURE, MECHANISM, AND EVOLUTION

1986 • 690 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Predicting the orientation of eukaryotic membrane-spanning proteins.

1989 • 596 citations

Nucleotide sequence of an Escherichia coli chromosomal hemolysin

1985 • 572 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

ATP SYNTHASE (H⁺-ATPase): Results by Combined Biochemical and Molecular Biological Approaches

1989 • 514 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

Enzymes Required for Yeast Prohormone Processing

1988 • 446 citations

Amplification of a Gene Related to Mammalian mdr Genes in Drug-Resistant Plasmodium falciparum

1989 • 439 citations

Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis.

1988 • 436 citations

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1986 • 410 citations

Nucleic acid hybridization: A practical approach

1987 • 404 citations

Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase

1983 • 403 citations

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.

1988 • 373 citations

Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP–binding domains

1989 • 357 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium

1982 • 322 citations

Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor.

1986 • 305 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Protein Localization and Membrane Traffic in Yeast

1985 • 267 citations

Molecular characterization of the oligopeptide permease of Salmonella typhimurium

1987 • 263 citations

RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor

1986 • 259 citations

Conjugation in Saccharomyces cerevisiae

1988 • 248 citations

The yeast STE12 protein binds to the DNA sequence mediating pheromone induction.

1989 • 245 citations

Nucleotide binding by membrane components of bacterial periplasmic binding protein-dependent transport systems.

1985 • 219 citations

Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

1982 • 216 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Spectrophotometric quantitation of silver grains eluted from autoradiograms

1983 • 195 citations

The export of the DNA replication inhibitor Microcin B17 provides immunity for the host cell.

1988 • 188 citations

THE SYNTHESIS AND FUNCTION OF PROTEASES IN SACCHAROMYCES: GENETIC APPROACHES

1984 • 179 citations

Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport.

1989 • 164 citations

Analytical Microbiology

1963 • 140 citations

ATP-binding sites in the membrane components of histidine permease, a periplasmic transport system.

1984 • 137 citations

Negative regulation of STE6 gene expression by the alpha 2 product of Saccharomyces cerevisiae.

1984 • 93 citations

Protein Transport and Secretion

1986 • 92 citations

Amino acid sequences of a-factor mating peptides from Saccharomyces cerevisiae.

1987 • 78 citations

Sequences upstream of the STE6 gene required for its expression and regulation by the mating type locus in Saccharomyces cerevisiae.

1986 • 70 citations

Physiological Characterization of Saccharomyces cerevisiae Mutants Supersensitive to G1 Arrest by a Factor and α Factor Pheromones

1982 • 65 citations

Extracellular suppression allows mating by pheromone-deficient sterile mutants of Saccharomyces cerevisiae

1983 • 47 citations

Active transport of maltose in membrane vesicles obtained from Escherichia coli cells producing tethered maltose-binding protein

1989 • 46 citations

Identification and localization of the membrane‐associated, ATP‐binding subunit of the oligopeptide permease of Salmonella typhimurium

1989 • 44 citations

Negative Regulation of STE6 Gene Expression by the α2 Product of Saccharomyces cerevisiae

1984 • 24 citations