A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma

1991 • 447 citations

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

1987 • 289 citations

Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.

1991 • 248 citations

Function and Regulation of the Human Multidrug Resistance Gene

1992 • 186 citations

The role of the MDR1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo

1992 • 183 citations

The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter

1992 • 172 citations

Resistance to multiple chemotherapeutic agents in human cancer cells

1988 • 161 citations

Serum-Inducible Genes

1989 • 143 citations

Transactivation of c-fos and β-actin genes by raf as a step in early response to transmembrane signals

1990 • 138 citations

Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals

1988 • 125 citations

A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene.

1993 • 124 citations

raf Family Serine/Threonine Protein Kinases in Mitogen Signal Transduction

1988 • 124 citations

Activation of the Serum Response Element and 12-O-Tetradecanoylphorbol-13-Acetate Response Element by the Activated c-raf-1 Protein in a Manner Independent of Protein Kinase C

1989 • 71 citations

An inhibitory mutant of c-Raf-1 blocks v-Src-induced activation of the Egr-1 promoter.

1991 • 67 citations

v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts.

1991 • 53 citations

The human multidrug resistance gene: sequences upstream and downstream of the initiation site influence transcription.

1990 • 48 citations

An inhibitory Raf-1 mutant suppresses expression of a subset of v-raf-activated genes

1993 • 35 citations

Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements.

1992 • 23 citations