Sequence of mdr3 cDNA encoding a human P-glycoprotein

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Construction of Phylogenetic Trees

1967 • 3,637 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

1984 • 2,234 citations

Signal sequences

1985 • 2,179 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Intracellular protein topogenesis

1980 • 1,378 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

1986 • 753 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

The evolution of genes: the chicken preproinsulin gene

1980 • 725 citations

Multiple Mechanisms of Protein Insertion into and Across Membranes

1985 • 720 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

1983 • 436 citations

Molecular Actions and Targets for Cancer Chemotherapeutic Agents

1981 • 361 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Powerful and versatile enhancer-promoter unit for mammalian expression vectors

1986 • 263 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Mechanism of cross-resistance between vincristine and daunorubicin in Ehrlich ascites tumor cells.

1978 • 231 citations

Genes amplified and overexpressed in human multidrug-resistant cell lines.

1988 • 170 citations

Multidrug Resistance of DNA-Mediated Transformants is Linked to Transfer of the Human mdr1 Gene

1986 • 161 citations

The transmembrane segment of the human transferrin receptor functions as a signal peptide.

1986 • 151 citations

Construction of phylogenetic trees for proteins and nucleic acids: Empirical evaluation of alternative matrix methods

1978 • 131 citations

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.

1986 • 113 citations

Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.

1986 • 102 citations

Exceptional lethality for nude mice of cells derived from a primary human melanoma.

1985 • 95 citations

Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells.

1987 • 84 citations

Genetics of multidrug resistance: relationship of a cloned gene to the complete multidrug resistant phenotype.

1987 • 81 citations

Active efflux common to vincristine and daunorubicin in vincristine-resistant P388 leukemia

1981 • 77 citations

DNA-mediated transfer and cloning of a human multidrug-resistant gene of adriamycin-resistant myelogenous leukemia K562.

1987 • 70 citations

Expression of hamster P-glycoprotein and multidrug resistance in DNA-mediated transformants of mouse LTA cells.

1987 • 63 citations

Deletion analysis of the internal signal-anchor domain of the human asialoglycoprotein receptor H1.

1987 • 40 citations

Amplification and overexpression of the P-glycoprotein genes and differential amplification of three other genes in SEWA murine multidrug-resistant cells

2008 • 18 citations

Deleted Work

1955 • 0 citations