Protein degradation and the generation of MHC class I-presented peptides

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells

1974 • 1,775 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

2000 • 1,477 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1999 • 1,447 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Proteasome inhibitors: from research tools to drug candidates

2001 • 1,159 citations

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

2001 • 1,118 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2

1976 • 1,060 citations

Cellular Defenses against Unfolded Proteins

2001 • 979 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

Epoxomicin, a potent and selective proteasome inhibitor, exhibitsin vivoantiinflammatory activity

1999 • 914 citations

A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

1998 • 901 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

Cross-Presentation, Dendritic Cells, Tolerance and Immunity

2001 • 894 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules

1995 • 882 citations

Ubiquitin-mediated proteolysis: biological regulation via destruction

2000 • 839 citations

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

1997 • 837 citations

Inhibition of antigen processing by the internal repeat region of the Epstein–Barr virus nuclear antigen-1

1995 • 820 citations

Lysosomal cysteine proteases: more than scavengers

2000 • 818 citations

A gated channel into the proteasome core particle.

2000 • 791 citations

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

1992 • 780 citations

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.

1980 • 727 citations

Structure and physiological function of calpains

1997 • 710 citations

ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway

1996 • 704 citations

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

1999 • 702 citations

Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome

2001 • 687 citations

Whose end is destruction: cell division and the anaphase-promoting complex

1999 • 679 citations

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

1998 • 674 citations

CD91: a receptor for heat shock protein gp96

2000 • 673 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

The ubiquitin system

2000 • 627 citations

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

1978 • 622 citations

A protein catalytic framework with an N-terminal nucleophile is capable of self-activation

1995 • 609 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.

1996 • 571 citations

The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

1999 • 565 citations

A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.

1977 • 553 citations

Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein–Barr virus nuclear antigen 1

1997 • 549 citations

Purification of two high molecular weight proteases from rabbit reticulocyte lysate.

1987 • 542 citations

Proteasomal Proteomics: Identification of Nucleotide-sensitive Proteasome-interacting Proteins by Mass Spectrometric Analysis of Affinity-purified Proteasomes

2000 • 542 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation.

1980 • 530 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

Differences in antigen presentation to MHC class I-and class II-restricted influenza virus-specific cytolytic T lymphocyte clones.

1986 • 513 citations

Structural basis for the activation of 20S proteasomes by 11S regulators

2000 • 503 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

Activation of the cell death program by inhibition of proteasome function

1997 • 494 citations

The base of the proteasome regulatory particle exhibits chaperone-like activity

1999 • 485 citations

The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome

2000 • 478 citations

The proteasome inhibitor PS-341 in cancer therapy.

1999 • 475 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

Proteasome Inhibition Leads to a Heat-shock Response, Induction of Endoplasmic Reticulum Chaperones, and Thermotolerance

1997 • 464 citations

Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF ^TIR1 in Mediating Auxin Response

2001 • 463 citations

Gettin’ down with ubiquitin: turning off cell-surface receptors, transporters and channels

1999 • 461 citations

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

1993 • 453 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors

1997 • 441 citations

Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?

1996 • 440 citations

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

1992 • 439 citations

Cellular peptide composition governed by major histocompatibility complex class I molecules

1990 • 438 citations

Ubiquitination

1991 • 430 citations

A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC

1991 • 427 citations

Processing of Some Antigens by the Standard Proteasome but Not by the Immunoproteasome Results in Poor Presentation by Dendritic Cells

2000 • 418 citations

The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release

2001 • 413 citations

The major substrates for TAP in vivo are derived from newly synthesized proteins

2000 • 408 citations

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

1999 • 406 citations

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

2001 • 397 citations

Selective Inhibitors of the Proteasome-dependent and Vacuolar Pathways of Protein Degradation in Saccharomyces cerevisiae

1996 • 395 citations

Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes.

1980 • 393 citations

Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation

1997 • 388 citations

Role of Cue1p in Ubiquitination and Degradation at the ER Surface

1997 • 386 citations

Purification of an 11 S regulator of the multicatalytic protease.

1992 • 384 citations

A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

1999 • 377 citations

Interferon-γ Induces Different Subunit Organizations and Functional Diversity of Proteasomes1

1994 • 371 citations

Retrograde protein translocation: ERADication of secretory proteins in health and disease

1999 • 371 citations

Chemistry of peptides associated with MHC class I and class II molecules

1995 • 371 citations

Inhibition of TNF-induced apoptosis by NF-κB

1998 • 370 citations

Properties of the caspases

1998 • 370 citations

Cloning, Isolation, and Characterization of Mammalian Legumain, an Asparaginyl Endopeptidase

1997 • 368 citations

Targeting of substrates to the 26S proteasome

1997 • 362 citations

Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity

1996 • 362 citations

An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation

1998 • 362 citations

Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

1983 • 356 citations

Complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells

1975 • 350 citations

Hybrid Proteasomes

2000 • 342 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

1998 • 340 citations

The nature of the MHC class I peptide loading complex

1999 • 332 citations

PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone

2000 • 330 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

1993 • 323 citations

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

2001 • 322 citations

Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1

1998 • 318 citations

A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentation

1993 • 317 citations

Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

2001 • 316 citations

Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.

1994 • 314 citations

Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.

1994 • 314 citations

Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome

1998 • 306 citations

Proteolytic Cleavage of Human p53 by Calpain: a Potential Regulator of Protein Stability

1997 • 305 citations

Proteasome Inhibitors Activate Stress Kinases and Induce Hsp72

1998 • 304 citations

Cyclin Ubiquitination: The destructive end of mitosis

1995 • 304 citations

Soluble Tapasin Restores MHC Class I Expression and Function in the Tapasin-Negative Cell Line .220

1998 • 298 citations

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase

1998 • 297 citations

Covalent modification of all members of human cullin family proteins by NEDD8

1999 • 295 citations

Lysosome-endosome fusion and lysosome biogenesis

2000 • 292 citations

Subcellular localization of proteasomes and their regulatory complexes in mammalian cells

2000 • 291 citations

Differential Inhibition of Calpain and Proteasome Activities by Peptidyl Aldehydes of Di-Leucine and Tri-Leucine

1996 • 288 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

Crystal Structure of Epoxomicin:20S Proteasome Reveals a Molecular Basis for Selectivity of α‘,β‘-Epoxyketone Proteasome Inhibitors

2000 • 285 citations

Proteasome Active Sites Allosterically Regulate Each Other, Suggesting a Cyclical Bite-Chew Mechanism for Protein Breakdown

1999 • 282 citations

Calpain inhibition: an overview of its therapeutic potential

1994 • 280 citations

Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.

1986 • 278 citations

The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria

1989 • 277 citations

SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53

2000 • 271 citations

A proteolytic system that compensates for loss of proteasome function

1998 • 271 citations

Ubiquitin‐dependent internalization and down‐regulation of plasma membrane proteins

1997 • 270 citations

Dynamics of proteasome distribution in living cells

1997 • 269 citations

Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide

1997 • 267 citations

Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants

1998 • 266 citations

The proteasome activator 11 S REG (PA28) and Class I antigen presentation

1999 • 262 citations

Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex

1991 • 262 citations

Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene

1991 • 256 citations

Noncaspase proteases in apoptosis

2000 • 255 citations

Two new proteases in the MHC class I processing pathway

2000 • 253 citations

The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex

1998 • 249 citations

Proteases and proteolysis in the lysosome

1992 • 240 citations

Making sense of the COP9 signalosome: a regulatory protein complex conserved from Arabidopsis to human

1999 • 237 citations

Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase

1992 • 235 citations

Proteases involved in MHC dass II antigen presentation

1999 • 235 citations

The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro

1995 • 233 citations

HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome.

1996 • 229 citations

Hepatitis B Virus X Protein Is both a Substrate and a Potential Inhibitor of the Proteasome Complex

1999 • 227 citations

Autocatalytic processing of the 20S proteasome

1996 • 226 citations

Proteasome Inhibitors Cause Induction of Heat Shock Proteins and Trehalose, Which Together Confer Thermotolerance in Saccharomyces cerevisiae

1998 • 226 citations

Regulatory subunit interactions of the 26S proteasome, a complex problem

2000 • 226 citations

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

1995 • 225 citations

Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

1997 • 220 citations

Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes

1998 • 219 citations

Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast

2000 • 219 citations

Novel Aspects of Degradation of T Cell Receptor Subunits from the Endoplasmic Reticulum (ER) in T Cells: Importance of Oligosaccharide Processing, Ubiquitination, and Proteasome-dependent Removal from ER Membranes

1998 • 218 citations

Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex

1992 • 217 citations

Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

1992 • 215 citations

Intracellular Localization of Proteasomal Degradation of a Viral Antigen

1999 • 214 citations

Range of Sizes of Peptide Products Generated during Degradation of Different Proteins by Archaeal Proteasomes

1998 • 208 citations

Structure of peptides associated with MHC class I molecules

1994 • 200 citations

Primary structures of two homologous subunits of PA28, a γ‐interferon‐inducible protein activator of the 20S proteasome

1995 • 196 citations

Presentation of Exogenous Protein Antigens on Major Histocompatability Complex Class I Molecules by Dendritic Cells: Pathway of Presentation and Regulation by Cytokines

1997 • 195 citations

Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.

1996 • 195 citations

Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome

2001 • 194 citations

Metabolism of ubiquitinated histones.

1981 • 193 citations

Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.

1996 • 191 citations

Structure of the proteasome activator REGα (PA28α)

1997 • 187 citations

PAProC: a prediction algorithm for proteasomal cleavages available on the WWW

2001 • 187 citations

Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes.

1992 • 184 citations

A New Inhibitor of the Chymotrypsin‐Like Activity of the Multicatalytic Proteinase Complex (20S Proteasome) Induces Accumulation of Ubiquitin‐Protein Conjugates in a Neuronal Cell

1994 • 183 citations

Existence of a molecular ruler in proteasomes suggested by analysis of degradation products

1994 • 179 citations

Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors

2001 • 177 citations

Impaired Immunoproteasome Assembly and Immune Responses in PA28 ^−/− Mice

1999 • 177 citations

Targeting of HIV-1 Antigens for Rapid Intracellular Degradation Enhances Cytotoxic T Lymphocyte (CTL) Recognition and the Induction of De Novo CTL Responses In Vivo After Immunization

1997 • 176 citations

The mouse and human genes encoding the recognition component of the N-end rule pathway

1998 • 175 citations

Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease.

1994 • 175 citations

An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes

1999 • 174 citations

A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1.

1988 • 173 citations

Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol

1996 • 172 citations

Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.

1994 • 172 citations

Proteasome complex as a potential cellular target of hepatitis B virus X protein

1996 • 170 citations

Rapid Deubiquitination of Nucleosomal Histones in Human Tumor Cells Caused by Proteasome Inhibitors and Stress Response Inducers: Effects on Replication, Transcription, Translation, and the Cellular Stress Response

1997 • 170 citations

Aminopeptidases: towards a mechanism of action.

1993 • 167 citations

Characterization of Recombinant REGα, REGβ, and REGγ Proteasome Activators

1997 • 164 citations

Proteasome Subunits X and Y Alter Peptidase Activities in Opposite Ways to the Interferon-γ-induced Subunits LMP2 and LMP7

1996 • 164 citations

Roles of proteasomes, transporter for antigen presentation (TAP), and beta 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway.

1996 • 163 citations

Puromycin-sensitive Aminopeptidase

1995 • 161 citations

Efficient Generation of a Hepatitis B Virus Cytotoxic T Lymphocyte Epitope Requires the Structural Features of Immunoproteasomes

2000 • 161 citations

The N-terminal region of tapasin is required to stabilize the MHC class I loading complex

1999 • 160 citations

Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.

1994 • 160 citations

Regulation of Cyclin D1 by Calpain Protease

1997 • 159 citations

Eponemycin exerts its antitumor effect through the inhibition of proteasome function.

1999 • 158 citations

Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta

2001 • 155 citations

Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes

1992 • 155 citations

An algorithm for the prediction of proteasomal cleavages

2000 • 154 citations

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling.

1994 • 151 citations

Major Histocompatibility Complex Class I-presented Antigenic Peptides Are Degraded in Cytosolic Extracts Primarily by Thimet Oligopeptidase

2001 • 147 citations

Downregulation of G protein-coupled receptors

2000 • 146 citations

Interferon-γ inducible exchanges of 20S proteasome active site subunits: Why?

2001 • 145 citations

Tripeptidyl peptidases: enzymes that count

1999 • 145 citations

Distinct Proteolytic Processes Generate the C and N Termini of MHC Class I-Binding Peptides

1999 • 144 citations

Structural and Functional Characterization of Interaction between Hepatitis B Virus X Protein and the Proteasome Complex

2000 • 141 citations

Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation.

1995 • 140 citations

Bone Marrow–Derived Antigen-Presenting Cells Are Required for the Generation of Cytotoxic T Lymphocyte Responses to Viruses and Use Transporter Associated with Antigen Presentation (Tap)-Dependent and -Independent Pathways of Antigen Presentation

2000 • 138 citations

A minimal glycine-alanine repeat prevents the interaction of ubiquitinated IκBα with the proteasome: a new mechanism for selective inhibition of proteolysis

1998 • 134 citations

Bovine Spleen Multicatalytic Proteinase Complex (Proteasome)

1997 • 133 citations

Proteasome β-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function

1999 • 131 citations

Molecular size-fractionation during endocytosis in macrophages.

1995 • 130 citations

The proteasome‐specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

1997 • 129 citations

Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport

1995 • 129 citations

Molecular properties of the proteasome activator PA28 family proteins and γ‐interferon regulation

1997 • 126 citations

c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells

2001 • 125 citations

Proteasomes Can Either Generate or Destroy MHC Class I Epitopes: Evidence for Nonproteasomal Epitope Generation in the Cytosol

1998 • 124 citations

The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope

1998 • 124 citations

Discrete Proteolytic Intermediates in the MHC Class I Antigen Processing Pathway and MHC I–Dependent Peptide Trimming in the ER

1999 • 123 citations

Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of IκBα

1999 • 122 citations

Overexpression of the Proteasome Subunits LMP2, LMP7, and MECL-1, But Not PA28α/β, Enhances the Presentation of an Immunodominant Lymphocytic Choriomeningitis Virus T Cell Epitope

2000 • 121 citations

The Class I Antigen-processing Pathway for the Membrane Protein Tyrosinase Involves Translation in the Endoplasmic Reticulum and Processing in the Cytosol

1998 • 120 citations

The Role of Tricorn Protease and Its Aminopeptidase-Interacting Factors in Cellular Protein Degradation

1998 • 119 citations

Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity

2000 • 118 citations

The cleavage preference of the proteasome governs the yield of antigenic peptides.

1995 • 117 citations

MHC Class I Antigen Processing of an Adenovirus CTL Epitope Is Linked to the Levels of Immunoproteasomes in Infected Cells

2000 • 117 citations

The Human 26 S and 20 S Proteasomes Generate Overlapping but Different Sets of Peptide Fragments from a Model Protein Substrate

2000 • 116 citations

The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts.

1985 • 113 citations

Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.

1994 • 112 citations

Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2.1 with high affinity and in different conformations.

1994 • 112 citations

Evidence That Endoplasmic Reticulum (ER)-associated Degradation of Cystic Fibrosis Transmembrane Conductance Regulator Is Linked to Retrograde Translocation from the ER Membrane

1999 • 112 citations

MHC class I antigen processing of Listeria monocytogenes proteins: implications for dominant and subdominant CTL responses

1997 • 112 citations

HIV-1 Tat Inhibits the 20 S Proteasome and Its 11 S Regulator-mediated Activation

1997 • 111 citations

The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing?

1997 • 108 citations

The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides.

1996 • 108 citations

Differential Influence on Cytotoxic T Lymphocyte Epitope Presentation by Controlled Expression of Either Proteasome Immunosubunits or Pa28

2000 • 106 citations

The Selective Proteasome Inhibitors Lactacystin and Epoxomicin Can Be Used to Either Up- or Down-Regulate Antigen Presentation at Nontoxic Doses

2000 • 106 citations

Evidence for an Interaction between Ubiquitin-Conjugating Enzymes and the 26S Proteasome

2000 • 106 citations

Tricorn Protease—The Core of a Modular Proteolytic System

1996 • 106 citations

Functional analysis of the proteasome regulatory particle.

1999 • 106 citations

Purification, substrate specificity, and classification of tripeptidyl peptidase II.

1986 • 103 citations

[32] Thimet oligopeptidase and oligopeptidase M or neurolysin

1995 • 100 citations

Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-I antigen-processing pathway.

1995 • 99 citations

Tapasin: an ER chaperone that controls MHC class I assembly with peptide

2001 • 97 citations

LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes

1995 • 97 citations

Evidence for the Existence of a Non-catalytic Modifier Site of Peptide Hydrolysis by the 20 S Proteasome

2000 • 96 citations

Effects of Major‐Histocompatibility‐Complex‐Encoded Subunits on the Peptidase and Proteolytic Activities of Human 20S Proteasomes

1996 • 95 citations

Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells.

1993 • 95 citations

Abrogation of CTL Epitope Processing by Single Amino Acid Substitution Flanking the C-Terminal Proteasome Cleavage Site

2000 • 95 citations

Proteasome inhibitor induced gene expression profiles reveal overexpression of transcriptional regulators ATF3, GADD153 and MAD1

2000 • 94 citations

The proteasome activator 11 S REG (PA28) and Class I antigen presentation

2000 • 93 citations

HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit

1995 • 92 citations

Comparison of human COP9 signalsome and 26S proteasome lid'.

1999 • 91 citations

Control of IκBα proteolysis by the ubiquitin-proteasome pathway

2001 • 91 citations

Class IMHC molecules: assembly and antigen presentation

1999 • 90 citations

Human Transporters Associated with Antigen Processing (Taps) Select Epitope Precursor Peptides for Processing in the Endoplasmic Reticulum and Presentation to T Cells

1999 • 89 citations

Regulation of the 26S proteasome by adenovirus E1A

2000 • 88 citations

Interferon γ regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies

2001 • 85 citations

Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival

2001 • 85 citations

Lessons from the discovery ofthe ubiquitin system

1996 • 84 citations

Molecular dissection of the 11S REG (PA28) proteasome activators

2001 • 83 citations

The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical Relevance

2001 • 82 citations

Inhibition of proteasomal degradation by the Gly-Ala repeat of Epstein–Barr virus is influenced by the length of the repeat and the strength of the degradation signal

2000 • 82 citations

Thimet Oligopeptidase (EC 3.4.24.15), a Novel Protein on the Route of MHC Class I Antigen Presentation

1999 • 80 citations

20S proteasome biogenesis

2001 • 80 citations

Cytotoxic T Lymphocyte Epitopes of HIV-1 Nef

2000 • 80 citations

Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities

1998 • 78 citations

Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28

2000 • 77 citations

p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts.

1996 • 76 citations

The specificity of proteasomes: impact on MHC class I processing and presentation of antigens

1999 • 76 citations

Allelic Differences in the Relationship Between Proteasome Activity and MHC Class I Peptide Loading

1998 • 75 citations

Studies on the Tissue Distribution of the Puromycin‐Sensitive Enkephalin‐Degrading Aminopeptidases

1988 • 74 citations

Subcellular localization of proteasomes and their regulatory complexes in mammalian cells

2000 • 74 citations

The substrate translocation channel of the proteasome

2001 • 74 citations

Structure and mechanism of ATP-dependent proteases

1999 • 73 citations

Proteasomes of the yeastS. cerevisiae: genes, structure and functions

1995 • 73 citations

Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease

1999 • 71 citations

Differential sensitivity of FOS and JUN family members to calpains.

1994 • 69 citations

Herpesvirus Evasion of the Immune System

1998 • 68 citations

Yeast sequencing reports. Sequence of the AFG3 gene encoding a new member of the FtsH/Yme1/Tma subfamily of the AAA‐protein family

1994 • 68 citations

Altered Properties of the Branched Chain Amino Acid-preferring Activity Contribute to Increased Cleavages after Branched Chain Residues by the “Immunoproteasome”

1998 • 67 citations

20S proteasome from LMP7 knock out mice reveals altered proteolytic activities and cleavage site preferences

1996 • 66 citations

Degradation of E2A Proteins through a Ubiquitin-conjugating Enzyme, UbcE2A

1997 • 66 citations

Cutting Edge: Induction of Enhanced CTL-Dependent Protective Immunity In Vivo by N-End Rule Targeting of a Model Tumor Antigen

1999 • 66 citations

Dissociation of Proteasomal Degradation of Biosynthesized Viral Proteins from Generation of MHC Class I-Associated Antigenic Peptides

1998 • 64 citations

Presentation of endogenous and exogenous antigens is not affected by inactivation of E1 ubiquitin-activating enzyme in temperature-sensitive cell lines.

1995 • 64 citations

Induction of leucine aminopeptidase by interferon-gamma. Identification by protein microsequencing after purification by preparative two-dimensional gel electrophoresis.

1992 • 63 citations

26 S Proteasome-mediated Production of an Authentic Major Histocompatibility Class I-restricted Epitope from an Intact Protein Substrate

1999 • 63 citations

Endoplasmic reticulum degradation. Reverse protein transport and its end in the proteasome.

1999 • 63 citations

Thimet Oligopeptidase and the Stability of MHC Class I Epitopes in Macrophage Cytosol

1999 • 60 citations

Double‐cleavage production of the CTL epitope by proteasomes and PA28: role of the flanking region

1997 • 59 citations

Sequence signals for generation of antigenic peptides by the proteasome: implications for proteasomal cleavage mechanism

2000 • 59 citations

GFP-labelling of 26S proteasomes in living yeast: insight into proteasomal functions at the nuclear envelope/rough ER.

1999 • 57 citations

Sequences That Flank Subdominant and Cryptic Epitopes Influence the Proteolytic Generation of MHC Class I-Presented Peptides

2000 • 56 citations

ATP- and antizyme-dependent endoproteolysis of ornithine decarboxylase to oligopeptides by the 26 S proteasome

1994 • 56 citations

The effect of the proteasome inhibitor lactacystin on the presentation of transporter associated with antigen processing (TAP)-dependent and TAP-independent peptide epitopes by class I molecules.

1997 • 55 citations

Interferon‐γ up‐regulates a unique set of proteins in human keratinocytes

1993 • 55 citations

Inactivation of a Defined Active Site in the Mouse 20S Proteasome Complex Enhances Major Histocompatibility Complex Class I Antigen Presentation of a Murine Cytomegalovirus Protein

1998 • 55 citations

Identification and Characterization of a DrosophilaNuclear Proteasome Regulator

2001 • 54 citations

Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells

2000 • 54 citations

Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex

1991 • 53 citations

Heat, heat shock, heat shock proteins and death: a central link in innate and adaptive immune responses

2000 • 52 citations

Selective involvement of proteasomes and cysteine proteases in MHC class I antigen presentation.

1997 • 52 citations

Chemical denaturation and modification of ovalbumin alters its dependence on ubiquitin conjugation for class I antigen presentation.

1996 • 50 citations

Identification of endogenous peptides recognized byin vivo orin vitro generated alloreactive cytotoxic T lymphocytes: distinct characteristics correlated with CD8 dependence

2001 • 48 citations

ATP-Dependent Inactivation and Sequestration of Ornithine Decarboxylase by the 26S Proteasome Are Prerequisites for Degradation

1999 • 47 citations

Kinetic Studies of the Branched Chain Amino Acid Preferring Peptidase Activity of the 20S Proteasome: Development of a Continuous Assay and Inhibition by Tripeptide Aldehydes and clasto-Lactacystin β-Lactone

1998 • 47 citations

Proteasome activity limits the assembly of MHC class I molecules after IFN-gamma stimulation.

1997 • 46 citations

Eubacterial proteasomes.

1997 • 46 citations

Contribution of Proline Residue for Efficient Production of MHC Class I Ligands by Proteasomes

1998 • 45 citations

Catalytic Components of the Bovine Pituitary Multicatalytic Proteinase Complex (Proteasome)

1993 • 44 citations

Sensitization of MHC class I-restricted T cells to exogenous proteins: evidence for an alternative class I-restricted antigen presentation pathway.

1995 • 43 citations

Cathepsins X and B Can Be Differentiated through Their Respective Mono- and Dipeptidyl Carboxypeptidase Activities

2001 • 43 citations

The efficiency of antigen delivery from macrophage phagosomes into cytoplasm for MHC class I-restricted antigen presentation

1997 • 42 citations

Yeast mitochondrial ATP‐dependent protease: purification and comparison with the homologous rat enzyme and the bacterial ATP‐dependent protease La

1993 • 40 citations

Newly Identified Pair of Proteasomal Subunits Regulated Reciprocally by Interferon γ

1997 • 39 citations

Peptide intermediates in the degradation of cellular proteins. Bestatin permits their accumulation in mouse liver in vivo.

1983 • 37 citations

Generation of naturally processed peptide/MHC class I complexes is independent of the stability of endogenously synthesized precursors.

1996 • 33 citations

Late Events in the Assembly of 20S Proteasomes

1998 • 32 citations

Specific inhibition of the chymotrypsin-like activity of the proteasome induces a bipolar morphology in neuroblastoma cells

1996 • 31 citations

Interaction of HTLV-I Tax with the Human Proteasome: Implications for NF-κB Induction

1996 • 31 citations

Components of the Bovine Pituitary Multicatalytic Proteinase Complex (Proteasome) Cleaving Bonds after Hydrophobic Residues

1999 • 30 citations

Protein degradation in MHC class II antigen presentation: opportunities for immunomodulation

2000 • 29 citations

Different size of the product of the 14S light chain mRNA translated in vitro and in amphibian oocytes

1973 • 25 citations

ATPase and ubiquitin-binding proteins of the yeast proteasome.

1997 • 25 citations

The role of tapasin in MHC class I antigen assembly

1999 • 23 citations

The proteasome inhibitor lactacystin prevents the generation of an endoplasmic reticulum leader—derived T cell epitope

1998 • 20 citations

Biochemical Purification of Distinct Proteasome Subsets

1993 • 20 citations

Lysozyme Degradation by the Bovine Multicatalytic Proteinase Complex (Proteasome): Evidence for a Nonprocessive Mode of Degradation

1999 • 20 citations

Generation of cytotoxic T-lymphocytes to a self-peptide/class I complex: a model for peptide-mediated tumor rejection.

1994 • 20 citations

Increased efficiency of folding and peptide loading of mutant MHC class I molecules

2000 • 20 citations

Production of a Specific Major Histocompatibility Complex Class I-restricted Epitope by Ubiquitin-dependent Degradation of Modified Ovalbumin in Lymphocyte Lysate

1997 • 19 citations

Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells

2000 • 18 citations

Cleavage of Pro-X and Glu-X Bonds Catalyzed by the Branched Chain Amino Acid Preferring Activity of the Bovine Pituitary Multicatalytic Proteinase Complex (20S Proteasome)

1996 • 18 citations

Anti-Peptide Antibody Blocks Peptide Binding to MHC Class I Molecules in the Endoplasmic Reticulum

2001 • 17 citations

PA28αβ double and PA28β single transfectant mouse B8 cell lines reveal enhanced presentation of a mouse cytomegalovirus (MCMV) pp89 MHC class I epitope

2000 • 11 citations

Cloning and heterogeneous in vivo expression of Tat binding protein-1 (TBP-1) in the mouse

1998 • 11 citations

Measurement of muscle protein degradation in live mice by accumulation of bestatin-induced peptides

1997 • 11 citations

MHC Class I Presentation of an Exogenous Polypeptide Antigen Encoded by the Murine AIDS Defective Virus

1997 • 10 citations

Epitope selection in major histocompatibility complex class I‐mediated pathway is affected by the intracellular localization of an antigen

1997 • 10 citations

Proteasomes generate in vitro a natural peptide of influenza-A nucleoprotein functional in HLA-B27 antigen assembly

1996 • 9 citations

Deleted Work

1955 • 0 citations