The specificity of proteasomes: impact on MHC class I processing and presentation of antigens

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

Inhibition of antigen processing by the internal repeat region of the Epstein–Barr virus nuclear antigen-1

1995 • 820 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

1999 • 565 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

The Active Sites of the Eukaryotic 20 S Proteasome and Their Involvement in Subunit Precursor Processing

1997 • 506 citations

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

1993 • 453 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors

1997 • 441 citations

On the active site of proteases. III. Mapping the active site of papain; specific peptide inhibitors of papain

1968 • 400 citations

A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

1999 • 377 citations

Interferon-γ Induces Different Subunit Organizations and Functional Diversity of Proteasomes1

1994 • 371 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

1993 • 323 citations

Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1

1998 • 318 citations

Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes.

1994 • 314 citations

Cation‐Sensitive Neutral Endopeptidase: Isolation and Specificity of the Bovine Pituitary Enzyme

1980 • 313 citations

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

1991 • 303 citations

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase

1998 • 297 citations

Mechanisms of Exogenous Antigen Presentation by MHC Class I Molecules in Vitro and in Vivo: Implications for Generating CD8+ T Cell Responses to Infectious Agents, Tumors, Transplants, and Vaccines

1999 • 293 citations

The MHC class I ligand‐generating system: roles of immunoproteasomes and the interferon‐4gMY‐inducible proteasome activator PA28

1998 • 288 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide

1997 • 267 citations

Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants

1998 • 266 citations

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

1992 • 250 citations

The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro

1995 • 233 citations

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

1995 • 225 citations

Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes

1998 • 219 citations

Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.

1994 • 216 citations

Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

1992 • 215 citations

MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL.

1997 • 207 citations

Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum

1997 • 200 citations

A Glycine-Rich Region in NF-κB p105 Functions as a Processing Signal for the Generation of the p50 Subunit

1996 • 196 citations

Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes.

1992 • 184 citations

A Single Residue Exchange Within a Viral CTL Epitope Alters Proteasome-Mediated Degradation Resulting in Lack of Antigen Presentation

1996 • 181 citations

Existence of a molecular ruler in proteasomes suggested by analysis of degradation products

1994 • 179 citations

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

1998 • 179 citations

Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.

1994 • 172 citations

Trimming of antigenic peptides in an early secretory compartment.

1994 • 169 citations

Incorporation of major histocompatibility complex – encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon‐γ

1995 • 167 citations

Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum.

1995 • 163 citations

A subset of HLA-B27 molecules contains peptides muchlonger than nonamers.

1994 • 161 citations

Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.

1994 • 160 citations

Pituitary multicatalytic proteinase complex. Specificity of components and aspects of proteolytic activity

1989 • 139 citations

A minimal glycine-alanine repeat prevents the interaction of ubiquitinated IκBα with the proteasome: a new mechanism for selective inhibition of proteolysis

1998 • 134 citations

Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a K^b‐restricted ovalbumin peptide and an assessment of the predictive power of MHC‐binding motifs

1992 • 134 citations

Bovine Spleen Multicatalytic Proteinase Complex (Proteasome)

1997 • 133 citations

Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport

1995 • 129 citations

A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20s proteasome 1 1Edited by R. Huber

1999 • 129 citations

The Sequence Alteration Associated with a Mutational Hotspot in p53 Protects Cells From Lysis by Cytotoxic T Lymphocytes Specific for a Flanking Peptide Epitope

1998 • 124 citations

Modulation of Proteasomal Activity Required for the Generation of a Cytotoxic T Lymphocyte–defined Peptide Derived from the Tumor Antigen MAGE-3

1999 • 124 citations

Retention of empty MHC class I molecules by tapasin is essential to reconstitute antigen presentation in invertebrate cells

1999 • 119 citations

The cleavage preference of the proteasome governs the yield of antigenic peptides.

1995 • 117 citations

Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.

1994 • 112 citations

MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies.

1997 • 110 citations

The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides.

1996 • 108 citations

Primary in vivo responses to ovalbumin. Probing the predictive value of the Kb binding motif.

1993 • 107 citations

Proteasomes and Antigen Processing

1997 • 106 citations

Generation and TAP-Mediated Transport of Peptides for Major Histocompatibility Complex Class I Molecules

1998 • 102 citations

Flanking residues alter antigenicity and immunogenicity of multi-unit CTL epitopes.

1996 • 102 citations

Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome)

1991 • 99 citations

LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes

1995 • 97 citations

Effects of Major‐Histocompatibility‐Complex‐Encoded Subunits on the Peptidase and Proteolytic Activities of Human 20S Proteasomes

1996 • 95 citations

MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation.

1994 • 94 citations

Point mutation flanking a CTL epitope ablates in vitro and in vivo recognition of a full-length viral protein.

1997 • 93 citations

Potential Immunocompetence of Proteolytic Fragments Produced by Proteasomes before Evolution of the Vertebrate Immune System

1997 • 87 citations

Effects of interferon gamma and major histocompatibility complex-encoded subunits on peptidase activities of human multicatalytic proteases.

1995 • 80 citations

CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope.

1992 • 79 citations

Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities

1998 • 78 citations

Chicken MHC Molecules, Disease Resistance and the Evolutionary Origin of Birds

1996 • 77 citations

Altered Properties of the Branched Chain Amino Acid-preferring Activity Contribute to Increased Cleavages after Branched Chain Residues by the “Immunoproteasome”

1998 • 67 citations

Decelerated degradation of short peptides by the 20S proteasome

1998 • 66 citations

Double‐cleavage production of the CTL epitope by proteasomes and PA28: role of the flanking region

1997 • 59 citations

Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product.

1991 • 58 citations

Promiscuous liberation of MHC-class I-binding peptides from the C termini of membrane and soluble proteins in the secretory pathway

1998 • 54 citations

Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation.

1994 • 48 citations

Kinetic Studies of the Branched Chain Amino Acid Preferring Peptidase Activity of the 20S Proteasome: Development of a Continuous Assay and Inhibition by Tripeptide Aldehydes and clasto-Lactacystin β-Lactone

1998 • 47 citations

Evidence That the Nature of Amino Acid Residues in the P3 Position Directs Substrates to Distinct Catalytic Sites of the Pituitary Multicatalytic Proteinase Complex (Proteasome)

1994 • 46 citations

Contribution of Proline Residue for Efficient Production of MHC Class I Ligands by Proteasomes

1998 • 45 citations

What do the paralogous regions in the genome tell us about the origin of the adaptive immune system?

1998 • 45 citations

Recognition of oligonucleotide-encoded T cell epitopes introduced into a gene unrelated to the original antigen.

1989 • 43 citations

Differential effects of flanking residues on presentation of epitopes from chimeric peptides

1994 • 40 citations

Presentation of viral antigens restricted by H‐2K^b, D^b or K^d in proteasome subunit LMP2‐and LMP7‐deficient cells

1994 • 38 citations

Self peptides bound by HLA class I molecules are derived from highly conserved regions of a set of evolutionarily conserved proteins

1995 • 37 citations

Functional analysis of amino acid residues encompassing and surrounding two neighboring H-2Db-restricted cytotoxic T-lymphocyte epitopes in simian virus 40 tumor antigen

1995 • 29 citations

The making of the dominant MHC class I ligand SYFPEITHI

1998 • 24 citations

Sequence of a Prominent 16-Residue Self-Peptide Bound to HLA-B27 in a Lymphoblastoid Cell Line

1993 • 21 citations

Gene transfer experiments imply instructive role of major histocompatibility complex class I molecules in cellular peptide processing

1992 • 20 citations

Peptide selection for presentation by HLA class I: A role for the human transporter associated with antigen processing?

1996 • 18 citations

To be or not to be a responder in T-cell responses: ubiquitous oligopeptides in all proteins

1991 • 14 citations

Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins

1995 • 13 citations