Eponemycin exerts its antitumor effect through the inhibition of proteasome function.

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

Lactacystin, Proteasome Function, and Cell Fate

1998 • 420 citations

Proteasomes: destruction as a programme

1996 • 373 citations

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin

1996 • 370 citations

Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor.

1998 • 277 citations

The ubiquitin-proteasome pathway in cancer

1998 • 223 citations

Lactacystin, a Specific Inhibitor of the Proteasome, Induces Apoptosis in Human Monoblast U937 Cells

1995 • 214 citations

The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-α-initiated apoptosis

1998 • 195 citations

Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits.

1992 • 119 citations

The ubiquitin-mediated proteolytic pathway as a therapeutic area

1997 • 113 citations

THE GENETICS OF PROTEASOMES AND ANTIGEN PROCESSING

1995 • 108 citations

Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.

1990 • 98 citations

Apoptosis of Ewing's sarcoma cells is accompanied by accumulation of ubiquitinated proteins.

1997 • 65 citations

Eponemycin analogues: syntheses and use as probes of angiogenesis

1998 • 63 citations

Enhancement of CPP32-like Activity in the TNF-Treated U937 Cells by the Proteasome Inhibitors

1996 • 58 citations

Eponemycin, a novel antibiotic, is a highly powerful angiogenesis inhibitor

1991 • 54 citations

Design and synthesis of novel protease inhibitors. Tripeptide α′,β′-epoxyketones as nanomolar inactivators of the proteasome

1996 • 50 citations

Specific inhibition of the chymotrypsin-like activity of the proteasome induces a bipolar morphology in neuroblastoma cells

1996 • 31 citations