The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

Recognition of the polyubiquitin proteolytic signal

2000 • 1,651 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

1998 • 901 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

A gated channel into the proteasome core particle.

2000 • 791 citations

The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

1999 • 565 citations

The Proteasome, a Novel Protease Regulated by Multiple Mechanisms

1999 • 540 citations

Structural basis for the activation of 20S proteasomes by 11S regulators

2000 • 503 citations

The Regulatory Particle of the Saccharomyces cerevisiae Proteasome

1998 • 487 citations

The base of the proteasome regulatory particle exhibits chaperone-like activity

1999 • 485 citations

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

1999 • 427 citations

THE PROTEASOME

1999 • 418 citations

Hybrid Proteasomes

2000 • 342 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone

2000 • 330 citations

26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

2001 • 322 citations

Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1

1998 • 318 citations

Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome

1998 • 306 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

Proteasome Active Sites Allosterically Regulate Each Other, Suggesting a Cyclical Bite-Chew Mechanism for Protein Breakdown

1999 • 282 citations

The proteasome activator 11 S REG (PA28) and Class I antigen presentation

1999 • 262 citations

Structural Features of the 26 S Proteasome Complex

1993 • 255 citations

Two new proteases in the MHC class I processing pathway

2000 • 253 citations

Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP

2000 • 249 citations

Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome.

1994 • 238 citations

Range of Sizes of Peptide Products Generated during Degradation of Different Proteins by Archaeal Proteasomes

1998 • 208 citations

Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum

1997 • 200 citations

Existence of a molecular ruler in proteasomes suggested by analysis of degradation products

1994 • 179 citations

An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes

1999 • 174 citations

Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP

2000 • 154 citations

Distinct Proteolytic Processes Generate the C and N Termini of MHC Class I-Binding Peptides

1999 • 144 citations

The Human 26 S and 20 S Proteasomes Generate Overlapping but Different Sets of Peptide Fragments from a Model Protein Substrate

2000 • 116 citations

Evidence for the Existence of a Non-catalytic Modifier Site of Peptide Hydrolysis by the 20 S Proteasome

2000 • 96 citations

The proteasome activator 11 S REG (PA28) and Class I antigen presentation

2000 • 93 citations

Activation of the multicatalytic protease. The 11 S regulator and 20 S ATPase complexes contain distinct 30-kilodalton subunits

1994 • 76 citations

Structure and mechanism of ATP-dependent proteases

1999 • 73 citations

Structural and Functional Characterizations of the Proteasome-activating Protein PA26 from Trypanosoma brucei

1999 • 72 citations

Decelerated degradation of short peptides by the 20S proteasome

1998 • 66 citations