Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Handbook of Proteolytic Enzymes

2004 • 2,698 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

1997 • 1,724 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

The Handbook of proteolytic enzymes

1998 • 1,123 citations

Complete Genome Sequence of Treponema pallidum , the Syphilis Spirochete

1998 • 1,060 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Mapping the active site of papain with the aid of peptide substrates and inhibitors

1970 • 410 citations

[33] AMoRe: An automated molecular replacement program package

1997 • 365 citations

Improved Structure Refinement Through Maximum Likelihood

1996 • 341 citations

Self-compartmentalizing proteases

1997 • 216 citations

Crystal Structure of a Conserved Protease That Binds DNA: the Bleomycin Hydrolase, Gal6

1995 • 157 citations

Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity.

1983 • 133 citations

Human Bleomycin Hydrolase: Molecular Cloning, Sequencing, Functional Expression, and Enzymatic Characterization

1996 • 107 citations

The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance

1999 • 102 citations

BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase.

1993 • 80 citations

Cloning and sequencing of pepC, a cysteine aminopeptidase gene from Lactococcus lactis subsp. cremoris AM2

1993 • 78 citations

Drug Resistance in Cancer Therapy

1989 • 77 citations

Characterization of the Lactobacillus helveticus CNRZ32 pepC gene

1994 • 73 citations

Metabolic inactivation: a mechanism of human tumor resistance to bleomycin.

1991 • 57 citations

The Unusual Active Site of Gal6/Bleomycin Hydrolase Can Act as a Carboxypeptidase, Aminopeptidase, and Peptide Ligase

1998 • 54 citations

Gene Cloning and Characterization of PepC, a Cysteine Aminopeptidase from Streptococcus thermophilus, with sequence Similarity to the Eucaryotic Bleomycin Hydrolase

1994 • 54 citations

Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.

1996 • 52 citations

Characterization and Expression of the Lactobacillus helveticus pepC Gene Encoding a General Aminopeptidase

1994 • 51 citations

Yeast bleomycin hydrolase is a DNA-binding cysteine protease. Identification, purification, biochemical characterization.

1994 • 43 citations

Association between bleomycin hydrolase and Alzheimer's disease in caucasians

1998 • 43 citations

Cloning and characterization of a cysteine proteinase from Saccharomyces cerevisiae.

1992 • 40 citations

The Cysteine-Peptidase Bleomycin Hydrolase Is A Member of the Galactose Regulon in Yeast

1997 • 39 citations

Purification and characterization of a second aminopeptidase (pepC-like) from Lactobacillus delbrueckii subsp. bulgaricus B14

1993 • 37 citations

Anticancer Drug Resistance

1994 • 32 citations

Essential Binding and Functional Domains of Human Bleomycin Hydrolase

1998 • 32 citations

A yeast gene (BLH1) encodes a polypeptide with high homology to vertebrate bleomycin hydrolase, a family member of thiol proteinases

1993 • 30 citations

The Nucleic Acid Binding Activity of Bleomycin Hydrolase Is Involved in Bleomycin Detoxification

1998 • 28 citations

Cloning and Analysis of cDNA Encoding Rat Bleomycin Hydrolase, a DNA-Binding Cysteine Protease

1996 • 24 citations

Separation of the protective enzyme bleomycin hydrolase from rabbit pulmonary aminopeptidases

1987 • 21 citations

cDNA Cloning and Expression of Chicken Aminopeptidase H, Possessing Endopeptidase as well as Aminopeptidase Activity

1997 • 16 citations

A Novel Brain Cysteine Protease Forms an SDS Stable Complex with the β‐Amyloid Precursor Proteina

1996 • 12 citations