Metabolism of ubiquitinated histones.

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.

1986 • 581 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Tumor necrosis factor.

1991 • 568 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

1990 • 529 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.

1992 • 464 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

Substrate specificity determinants for casein kinase II as deduced from studies with synthetic peptides.

1987 • 431 citations

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

1991 • 407 citations

Eggs: Conveniently packaged antibodies. Methods for purification of yolk IgG

1981 • 373 citations

Isolation of phosphorylated peptides and proteins on ion exchange papers

1978 • 359 citations

Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells.

1990 • 336 citations

Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.

1988 • 288 citations

The molecular action of tumor necrosis factor-alpha

1991 • 279 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669

1991 • 215 citations

Tumour necrosis factor (cachectin) induces phospholipase A2 activity and synthesis of a phospholipase A2-activating protein in endothelial cells

1988 • 203 citations

Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide.

1988 • 184 citations

Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.

1990 • 183 citations

Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro.

1990 • 175 citations

The catalytic subunits of protein phosphatase‐1 and protein phosphatase 2A are distinct gene products

1984 • 160 citations

Interleukin 1 and tumor necrosis factor activate common multiple protein kinases in human fibroblasts

1991 • 160 citations

Endogenous phosphate acceptor proteins for rat liver cytosolic casein kinases.

1981 • 153 citations

Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism

1987 • 121 citations

Purification and characterisation of the insulin‐stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II

1991 • 117 citations

Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.

1988 • 101 citations

Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.

1991 • 100 citations

Phosphoserine as a recognition determinant for glycogen synthase kinase-3: Phosphorylation of a synthetic peptide based on the G-component of protein phosphatase-1

1988 • 95 citations

Tumor necrosis factor-α induces the phosphorylation of 28kDa stress proteins in endothelial cells: Possible role in protection against cytotoxicity?

1989 • 87 citations

Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins

1988 • 86 citations

Signal transduction in yeast mating: Receptors, transcription factors, and the kinase connection

1991 • 71 citations

Binding of G-CSF, GM-CSF, tumor necrosis factor-alpha, and gamma- interferon to cell surface receptors on human myeloid leukemia cells triggers rapid tyrosine and serine phosphorylation of a 75-Kd protein

1990 • 69 citations

Characterization of maturation-activated histone H1 and ribosomal S6 kinases in sea star oocytes

1987 • 67 citations

Tumor necrosis factor induces phosphorylation of a 28-kDa mRNA cap-binding protein in human cervical carcinoma cells.

1989 • 58 citations

The divergent receptors for TNF

1990 • 50 citations

Mitogenic signalling pathway of tumour necrosis factor involves the rapid tyrosine phosphorylation of 41,000-Mr and 43,000-Mr cytosol proteins

1990 • 44 citations

Rapid stimulation of Ser/Thr protein kinases following treatment of Swiss 3T3 cells with bombesin. Involvement of casein kinase-2 in the signaling pathway of bombesin.

1992 • 23 citations

The activity of protein kinases from hamster fibroblasts towards a synthetic peptide based on a carboxy-terminal portion of ribosomal protein S6

1990 • 6 citations