The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.

1991 • 874 citations

Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control.

1994 • 815 citations

Herpes simplex virus turns off the TAP to evade host immunity

1995 • 736 citations

Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane

1993 • 654 citations

A protein-conducting channel in the endoplasmic reticulum

1991 • 613 citations

A viral inhibitor of peptide transporters for antigen presentation

1995 • 599 citations

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes

1994 • 553 citations

Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products.

1986 • 547 citations

SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion

1994 • 529 citations

N-glycans as apical sorting signals in epithelial cells

1995 • 454 citations

A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

1992 • 450 citations

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.

1990 • 435 citations

GENERATION, TRANSLOCATION, AND PRESENTATION OF MHC CLASS I-RESTRICTED PEPTIDES

1995 • 428 citations

An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens

1985 • 405 citations

Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p

1995 • 400 citations

Proteasomes: multicatalytic proteinase complexes

1993 • 395 citations

Mitochondrial Hsp70/MIM44 complex facilitates protein import

1994 • 391 citations

Sec61p and BiP directly facilitate polypeptide translocation into the ER

1992 • 370 citations

Folding of influenza hemagglutinin in the endoplasmic reticulum.

1991 • 318 citations

[4] Enzymatic deglycosylation of asparagine-linked glycans: Purification, properties, and specificity of oligosaccharide-cleaving enzymes from Flavobacterium meningosepticum

1994 • 284 citations

Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains

1995 • 278 citations

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.

1993 • 215 citations

Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment.

1992 • 204 citations

SecA protein is exposed to the periplasmic surface of the E. coli inner membrane in its active state

1994 • 158 citations

Purification and enzymatic properties of peptide:N-glycanase from C3H mouse-derived L-929 fibroblast cells. Possible widespread occurrence of post-translational remodification of proteins by N-deglycosylation

1994 • 141 citations

Modulation of MHC antigen expression by viruses and oncogenes

1991 • 128 citations

An analysis of class I antigens of man and other species by one-dimensional IEF and immunoblotting

1986 • 95 citations

In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.

1993 • 91 citations

Intracellular compartmentalization and degradation of free polymannose oligosaccharides released during glycoprotein biosynthesis.

1994 • 84 citations

Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen.

1995 • 81 citations

Replacement mutagenesis of the human cytomegalovirus genome: US10 and US11 gene products are nonessential

1991 • 62 citations

Proteolytic activity of human cytomegalovirus UL80 protease cleavage site mutants

1994 • 46 citations

Tetracycline repressor-regulated gene repression in recombinant human cytomegalovirus

1995 • 43 citations

One‐Dimensional Isoelectric Focusing of Proteins in Slab Gels

1995 • 39 citations

The effect of anchor residue modifications on the stability of major histocompatibility complex class I‐peptide interactions

1993 • 37 citations

Activation of protein kinase C accelerates internalization of transferrin receptor but not of major histocompatibility complex class I, independent of their phosphorylation status.

1992 • 34 citations

ON THE DIRECTION OF PYRIDINE NUCLEOTIDE OXIDATION-REDUCTION REACTIONS IN GLUCONEOGENSIS AND LIPOGENESIS++0ur experimental work on gluconeogenesis has been supported by NSF, NIH and the Eli Lilly Co.

1965 • 12 citations