Characterization of Recombinant REGα, REGβ, and REGγ Proteasome Activators

A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.

1985 • 3,185 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

1992 • 780 citations

Detection of Calcium Binding Proteins by 45Ca Autoradiography on Nitrocellulose Membrane after Sodium Dodecyl Sulfate Gel Electrophoresis1

1984 • 772 citations

The interferon system. A bird's eye view of its biochemistry.

1992 • 633 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

1992 • 439 citations

Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm.

1994 • 395 citations

Purification of an 11 S regulator of the multicatalytic protease.

1992 • 384 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.

1986 • 278 citations

The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria

1989 • 277 citations

PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.

1993 • 260 citations

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.

1991 • 246 citations

The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro

1995 • 233 citations

Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate.

1992 • 229 citations

HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome.

1996 • 229 citations

Peptide antigen production by the proteasome: complexity provides efficiency

1996 • 228 citations

Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

1995 • 225 citations

Primary structures of two homologous subunits of PA28, a γ‐interferon‐inducible protein activator of the 20S proteasome

1995 • 196 citations

Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.

1996 • 195 citations

In Vivo Assembly of the Proteasomal Complexes, Implications for Antigen Processing

1995 • 193 citations

Proteasomes are regulated by interferon gamma: implications for antigen processing.

1992 • 177 citations

Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease.

1994 • 175 citations

KEKE motifs

1994 • 173 citations

Degradation of the Proto-Oncogene Product c-Fos by the Ubiquitin Proteolytic System In Vivo and In Vitro: Identification and Characterization of the Conjugating Enzymes

1995 • 167 citations

Electron microscopy and image analysis of the multicatalytic proteinase

1988 • 150 citations

The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis.

1993 • 149 citations

Localization of subunits in proteasomes from Thermoplasma acidophilum by immunoelectron microscopy

1991 • 123 citations

PRE5 and PRE6, the Last Missing Genes Encoding 20S Proteasome Subunits from Yeast? Indication for a Set of 14 Different Subunits in the Eukaryotic Proteasome Core

1994 • 121 citations

Purification and characterization of a multiprotein component of the Drosophila 26 S (1500 kDa) proteolytic complex.

1993 • 108 citations

The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides.

1996 • 108 citations

Ubiquitin-lysozyme conjugates. Purification and susceptibility to proteolysis.

1986 • 108 citations

Effects of Major‐Histocompatibility‐Complex‐Encoded Subunits on the Peptidase and Proteolytic Activities of Human 20S Proteasomes

1996 • 95 citations

Characterization of the Proteasome Regulator PA28

1996 • 93 citations

The three‐dimensional structure of proteasomes from Thermoplasma acidophilum as determined by electron microscopy using random conical tilting

1991 • 92 citations

Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected with sera from patients with systemic lupus erythematosus

1990 • 86 citations

PRE3, highly homologous to the human major histocompatibility complex‐linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl‐peptide hydrolyzing activity

1994 • 80 citations

Effects of interferon gamma and major histocompatibility complex-encoded subunits on peptidase activities of human multicatalytic proteases.

1995 • 80 citations

Activation of the multicatalytic protease. The 11 S regulator and 20 S ATPase complexes contain distinct 30-kilodalton subunits

1994 • 76 citations

A Model for the Quaternary Structure of the Proteasome Activator PA28

1996 • 76 citations

Size and shape of the multicatalytic proteinase from rat skeletal muscle

1986 • 73 citations

Molecular Cloning and Expression of a 26 S Protease Subunit Enriched in Dileucine Repeats

1995 • 67 citations

20S proteasome from LMP7 knock out mice reveals altered proteolytic activities and cleavage site preferences

1996 • 66 citations

Proteasome Activator PA28 and Its Interaction with 20 S Proteasomes

1996 • 55 citations

Interferon‐γ up‐regulates a unique set of proteins in human keratinocytes

1993 • 55 citations

A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex

1992 • 50 citations

The human proteasome subunit HsN3 is located inthe inner rings of the complex dimer

1995 • 50 citations

A Proteasome Activator Subunit Binds Calcium

1995 • 49 citations

Human lymphoblast and erythrocyte multicatalytic proteases: differential peptidase activities and responses to the 11S regulator

1995 • 43 citations

Reconstitution of proteasome activator PA28 from isolated subunits: optimal activity is associated with an α,β-heteromultimer

1996 • 43 citations

Synthesis of Peptides as Cloned Ubiquitin Extensions

1989 • 36 citations

Ubiquitin metabolism in cycling Xenopus egg extracts.

1993 • 31 citations

Regulatory features of multicatalytic and 26S proteases

1996 • 27 citations

Proposed Role of a γ-Interferon Inducible Proteasome-Regulator in Antigen Presentation

1996 • 6 citations