Lysosome-endosome fusion and lysosome biogenesis

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

ENDOCYTOSIS AND MOLECULAR SORTING

1996 • 1,537 citations

Endocytosis

1997 • 1,263 citations

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

1998 • 1,101 citations

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

1998 • 1,032 citations

Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

1988 • 977 citations

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

1995 • 955 citations

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

1996 • 904 citations

Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.

1992 • 832 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

The fungal vacuole: composition, function, and biogenesis

1990 • 758 citations

A Membrane Coat Complex Essential for Endosome-to-Golgi Retrograde Transport in Yeast

1998 • 716 citations

Altered Trafficking of Lysosomal Proteins in Hermansky-Pudlak Syndrome Due to Mutations in the β3A Subunit of the AP-3 Adaptor

1999 • 663 citations

Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body

1998 • 652 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

1999 • 628 citations

Phosphatidylinositol-3-OH kinases are Rab5 effectors

1999 • 625 citations

Rab 7: an important regulator of late endocytic membrane traffic.

1995 • 625 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13

1999 • 523 citations

Sorting and storage during secretory granule biogenesis: looking backward and looking forward

1998 • 516 citations

PROTEINASE MUTANTS OF SACCHAROMYCES CEREVISIAE

1977 • 460 citations

Homotypic vacuolar fusion mediated by t- and v-SNAREs

1997 • 457 citations

Transport-vesicle targeting: tethers before SNAREs

1999 • 451 citations

Rab GTPases coordinate endocytosis

2000 • 447 citations

The AP-3 Adaptor Complex Is Essential for Cargo-Selective Transport to the Yeast Vacuole

1997 • 430 citations

Movement of internalized ligand–receptor complexes along a continuous endosomal reticulum

1990 • 428 citations

Lysosomes revisited

1983 • 427 citations

Molecular Bases for the Recognition of Tyrosine-based Sorting Signals

1999 • 414 citations

Cytoplasmic dynein-dependent vesicular transport from early to late endosomes [published erratum appears in J Cell Biol 1994 Feb;124(3):397]

1993 • 408 citations

Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products

1997 • 393 citations

Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion

1998 • 390 citations

AP-3: an adaptor-like protein complex with ubiquitous expression

1997 • 389 citations

TIP47: A Cargo Selection Device for Mannose 6-Phosphate Receptor Trafficking

1998 • 386 citations

Association of the AP-3 Adaptor Complex with Clathrin

1998 • 384 citations

The Niemann-Pick C1 Protein Resides in a Vesicular Compartment Linked to Retrograde Transport of Multiple Lysosomal Cargo

1999 • 375 citations

Characterization of the Adaptor-related Protein Complex, AP-3

1997 • 369 citations

A Multispecificity Syntaxin Homologue, Vam3p, Essential for Autophagic and Biosynthetic Protein Transport to the Vacuole

1997 • 349 citations

Defining the functions of trans-SNARE pairs

1998 • 343 citations

Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump.

1995 • 331 citations

SNARE Interactions Are Not Selective

1999 • 322 citations

Mixed and Non-cognate SNARE Complexes

1999 • 319 citations

Characterization of a Fourth Adaptor-related Protein Complex

1999 • 309 citations

A Novel RING Finger Protein Complex Essential for a Late Step in Protein Transport to the Yeast Vacuole

1997 • 304 citations

Syntaxin 13 Mediates Cycling of Plasma Membrane Proteins via Tubulovesicular Recycling Endosomes

1998 • 294 citations

AP-4, a Novel Protein Complex Related to Clathrin Adaptors

1999 • 292 citations

Intracellular trafficking of lysosomal membrane proteins

1996 • 277 citations

Rapid and efficient fusion of phospholipid vesicles by the α-helical core of a SNARE complex in the absence of an N-terminal regulatory domain

1999 • 259 citations

A novel adaptor-related protein complex.

1996 • 241 citations

Dense core lysosomes can fuse with late endosomes and are re-formed from the resultant hybrid organelles

1997 • 234 citations

Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis

1999 • 232 citations

Biogenesis of secretory granules in the trans-Golgi network of neuroendocrine and endocrine cells

1998 • 227 citations

The Yeast Adaptor Protein Complex, AP-3, Is Essential for the Efficient Delivery of Alkaline Phosphatase by the Alternate Pathway to the Vacuole

1997 • 218 citations

Fusion of Lysosomes with Late Endosomes Produces a Hybrid Organelle of Intermediate Density and Is NSF Dependent

1998 • 216 citations

Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activity

1999 • 214 citations

The Mammalian AP-3 Adaptor-like Complex Mediates the Intracellular Transport of Lysosomal Membrane Glycoproteins

1998 • 213 citations

Biosynthesis, glycosylation, movement through the Golgi system, and transport to lysosomes by an N-linked carbohydrate-independent mechanism of three lysosomal integral membrane proteins.

1986 • 212 citations

A Role for the deep orange and carnation Eye Color Genes in Lysosomal Delivery in Drosophila

1999 • 206 citations

Three Novel Proteins of the Syntaxin/SNAP-25 Family

1998 • 206 citations

Vamp-7 Mediates Vesicular Transport from Endosomes to Lysosomes

1999 • 202 citations

Abnormal transport along the lysosomal pathway in Mucolipidosis, type IV disease

1998 • 202 citations

FYVE-finger proteins – effectors of an inositol lipid

1999 • 199 citations

Vam7p, a SNAP-25-Like Molecule, and Vam3p, a Syntaxin Homolog, Function Together in Yeast Vacuolar Protein Trafficking

1998 • 199 citations

Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins.

1987 • 197 citations

Mouse Models of Hermansky Pudlak Syndrome: A Review

1998 • 192 citations

Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs

1999 • 189 citations

Lysosomal acid phosphatase is transported to lysosomes via the cell surface.

1989 • 189 citations

Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. I. Isolation and characterization of two classes of vam mutants.

1992 • 188 citations

The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles.

1996 • 188 citations

Maturation models for endosome and lysosome biogenesis

1991 • 172 citations

Isolation and characterization of early endosomes, late endosomes and terminal lysosomes: their role in protein degradation

1996 • 170 citations

Regulated Secretion from Hemopoietic Cells

1999 • 166 citations

Three v-SNAREs and Two t-SNAREs, Present in a Pentameric cis-SNARE Complex on Isolated Vacuoles, Are Essential for Homotypic Fusion

1999 • 166 citations

Control of the Terminal Step of Intracellular Membrane Fusion by Protein Phosphatase 1

1999 • 161 citations

Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles

1993 • 159 citations

Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery

1998 • 159 citations

Differential Roles of Syntaxin 7 and Syntaxin 8 in Endosomal Trafficking

1999 • 157 citations

Protein transport from the secretory to the endocytic pathway in mammalian cells

1998 • 156 citations

Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet

1997 • 154 citations

The Membrane Protein Alkaline Phosphatase Is Delivered to the Vacuole by a Route That Is Distinct from the VPS-dependent Pathway

1997 • 153 citations

Involvement of Ypt7p, a small GTPase, in traffic from late endosome to the vacuole in yeast

1993 • 150 citations

Lysosomes

1989 • 147 citations

The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?

1996 • 144 citations

Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast

1999 • 143 citations

The Beige/Chediak-Higashi Syndrome Gene Encodes a Widely Expressed Cytosolic Protein

1997 • 135 citations

β3A-adaptin, a Subunit of the Adaptor-like Complex AP-3

1997 • 134 citations

AP-2-containing clathrin coats assemble on mature lysosomes.

1996 • 132 citations

Formation of AP-3 transport intermediates requires Vps41 function

1999 • 130 citations

Retrograde Traffic Out of the Yeast Vacuole to the TGN Occurs via the Prevacuolar/Endosomal Compartment

1998 • 126 citations

Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes

1992 • 124 citations

Delivery to lysosomes in the human carcinoma cell line HEp-2 involves an actin filament-facilitated fusion between mature endosomes and preexisting lysosomes.

1995 • 122 citations

Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis.

1990 • 118 citations

Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network

1999 • 116 citations

Coupled Inositide Phosphorylation and Phospholipase D Activation Initiates Clathrin-coat Assembly on Lysosomes

1999 • 108 citations

Protein transport to the yeast vacuole

1995 • 102 citations

Vam3p, a new member of syntaxin related protein, is required for vacuolar assembly in the yeast Saccharomyces cerevisiae

1997 • 102 citations

Genetic Analysis of hook, a Gene Required for Endocytic Trafficking in Drosophila

1999 • 99 citations

Sorting of Lysosomal Membrane Glycoproteins lamp-1 and lamp-2 into Vesicles Distinct from Mannose 6-Phosphate Receptor/γ-Adaptin Vesicles at the trans-Golgi Network

1998 • 97 citations

On vesicles and membrane compartments

1996 • 94 citations

Molecular Characterization of the Protein Encoded by the Hermansky-Pudlak Syndrome Type 1 Gene

2000 • 94 citations

Biogenesis of transport intermediates in the endocytic pathway

1999 • 93 citations

Hermansky-Pudlak Syndrome: Models for Intracellular Vesicle Formation

1998 • 91 citations

Fusion of Endosomes Involved in Synaptic Vesicle Recycling

1999 • 83 citations

Genetic Dissection of Endocytic Trafficking inDrosophilaUsing a Horseradish Peroxidase-Bride of Sevenless Chimera:hookIs Required for Normal Maturation of Multivesicular Endosomes

1999 • 82 citations

YEB3/VAC8 encodes a myristylated armadillo protein of the Saccharomyces cerevisiae vacuolar membrane that functions in vacuole fusion and inheritance

1998 • 80 citations

Lysosomal Biogenesis in Lysosomal Storage Disorders

1997 • 78 citations

Lysosomes can fuse with a late endosomal compartment in a cell-free system from rat liver.

1994 • 73 citations

A non-autophagic pathway for diversion of ER secretory proteins to lysosomes.

1992 • 72 citations

Cell biology: The importance of the endosome in intracellular traffic

1983 • 70 citations

Reconstitution of Phagosome-Lysosome Fusion in StreptolysinO-permeabilized Cells

1997 • 69 citations

The Kinetics of Mannose 6-Phosphate Receptor Trafficking in the Endocytic Pathway in HEp-2 Cells: The Receptor Enters and Rapidly Leaves Multivesicular Endosomes without Accumulating in a Prelysosomal Compartment

1998 • 66 citations

Homotypic fusion between aggregated lysosomes triggered by elevated [Ca2+]i in fibroblasts

1997 • 64 citations

LvsA, a Protein Related to the Mouse Beige Protein, Is Required for Cytokinesis inDictyostelium

1999 • 54 citations

Homotypic Lysosome Fusion in Macrophages: Analysis Using an In Vitro Assay

1997 • 53 citations

Christian de Duve and the discovery of lysosomes and peroxisomes

1998 • 40 citations

Accumulation of Sialic Acid in Endocytic Compartments Interferes with the Formation of Mature Lysosomes

1999 • 39 citations

Hydrolases in intracellular compartments of rat liver cells

1991 • 34 citations

Genetic and biochemical studies of protein sorting to the yeast vacuole

1993 • 33 citations

Endosomes can undergo an ATP-dependent density increase in the absence of dense lysosomes.

1990 • 29 citations

Analyses of Proteins Involved in Vesicular Trafficking in Platelets of Mouse Models of Hermansky Pudlak Syndrome

1999 • 20 citations