Proteasome Active Sites Allosterically Regulate Each Other, Suggesting a Cyclical Bite-Chew Mechanism for Protein Breakdown

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

1999 • 565 citations

The Active Sites of the Eukaryotic 20 S Proteasome and Their Involvement in Subunit Precursor Processing

1997 • 506 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors

1997 • 441 citations

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

1992 • 439 citations

Selective Inhibitors of the Proteasome-dependent and Vacuolar Pathways of Protein Degradation in Saccharomyces cerevisiae

1996 • 395 citations

Autocatalytic Subunit Processing Couples Active Site Formation in the 20S Proteasome to Completion of Assembly

1996 • 390 citations

Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation

1997 • 388 citations

Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1

1998 • 318 citations

Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation

1997 • 295 citations

Ubiquitin and the Biology of the Cell

1998 • 274 citations

Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants

1998 • 266 citations

Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome.

1994 • 238 citations

Range of Sizes of Peptide Products Generated during Degradation of Different Proteins by Archaeal Proteasomes

1998 • 208 citations

Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum

1997 • 200 citations

Incorporation of major histocompatibility complex – encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon‐γ

1995 • 167 citations

Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome)

1991 • 99 citations

Kinetic studies of the differential effect of detergents on the peptidase activities of the multicatalytic proteinase from rat liver.

1990 • 89 citations

[24] Multicatalytic endopeptidase complex: Proteasome

1994 • 79 citations

Activation of the multicatalytic protease. The 11 S regulator and 20 S ATPase complexes contain distinct 30-kilodalton subunits

1994 • 76 citations

Functions of the Proteasome in Antigen Presentation

1995 • 56 citations

Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex

1991 • 53 citations

Peptidylglutamyl-peptide hydrolase activity of the multicatalytic proteinase complex: evidence for a new high-affinity site, analysis of cooperative kinetics, and the effect of manganese ions

1992 • 50 citations

A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex

1992 • 50 citations

Kinetic Studies of the Branched Chain Amino Acid Preferring Peptidase Activity of the 20S Proteasome: Development of a Continuous Assay and Inhibition by Tripeptide Aldehydes and clasto-Lactacystin β-Lactone

1998 • 47 citations

Multicatalytic endopeptidase complex

1998 • 1 citations