HIV-1 Tat Inhibits the 20 S Proteasome and Its 11 S Regulator-mediated Activation

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).

1992 • 439 citations

HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.

1995 • 386 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

Inhibition of Antigen-Induced Lymphocyte Proliferation by Tat Protein from HIV-1

1989 • 338 citations

Cyclin Ubiquitination: The destructive end of mitosis

1995 • 304 citations

Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.

1986 • 278 citations

A cDNA for a Protein That Interacts with the Human Immunodeficiency Virus Tat Transactivator

1990 • 234 citations

Conformational constraints in protein degradation by the 20S proteasome

1995 • 202 citations

Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease.

1994 • 175 citations

New human gene encoding a positive modulator of HIV Tat-mediated transactivation

1992 • 163 citations

Effects on NF-κB1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome

1996 • 137 citations

Molecular Characterization of the "26S" Proteasome Complex from Rat Liver

1993 • 131 citations

Subunits of the regulatory complex of the 26S protease

1995 • 127 citations

Activation of HIV transcription by Tat

1992 • 111 citations

Human immunodeficiency viruses regulated by alternative trans-activators: genetic evidence for a novel non-transcriptional function of Tat in virion infectivity.

1994 • 93 citations

HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit

1995 • 92 citations

Activation of the multicatalytic protease. The 11 S regulator and 20 S ATPase complexes contain distinct 30-kilodalton subunits

1994 • 76 citations

Characteristics of 26 S Proteases from Fission Yeast Mutants, which Arrest in Mitosis

1996 • 65 citations

The Proteasome Subunit, C2, Contains an Important Site for Binding of the PA28 (11S) Activator

1996 • 50 citations

Molecular cloning and expression of subunit 12: a non‐MCP and non‐ATPase subunit of the 26 S protease

1995 • 35 citations

Structural features of archaebacterial and eukaryotic proteasomes

1995 • 28 citations