Proteasomes of the yeastS. cerevisiae: genes, structure and functions

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

Recent advances in the biochemistry of polyamines in eukaryotes

1986 • 1,587 citations

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

1992 • 780 citations

Life cycle of the budding yeast Saccharomyces cerevisiae

1988 • 565 citations

Control of the yeast cell cycle by the Cdc28 protein kinase

1993 • 502 citations

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.

1993 • 483 citations

The N-end rule

1992 • 464 citations

S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase

1993 • 422 citations

Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.

1991 • 421 citations

Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor

1993 • 397 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

1989 • 370 citations

PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of putative ATPases

1991 • 344 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

1993 • 323 citations

Yeast cell cycle protein CDC48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression.

1991 • 302 citations

An abundant and ubiquitous homo-oligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins Sec18p and NSF.

1990 • 279 citations

Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates.

1986 • 278 citations

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme.

1991 • 268 citations

Ubiquitin as a degradation signal.

1992 • 261 citations

PRE2, highly homologous to the human major histocompatibility complex-linked RING10 gene, codes for a yeast proteasome subunit necessary for chrymotryptic activity and degradation of ubiquitinated proteins.

1993 • 260 citations

Structural Features of the 26 S Proteasome Complex

1993 • 255 citations

Nucleotide Sequence and Transcriptional Regulation of the Yeast Recombinational Repair Gene RAD51

1992 • 246 citations

Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit

1993 • 244 citations

In vivo degradation of a transcriptional regulator: The yeast α2 repressor

1990 • 243 citations

Life cycle of the budding yeast Saccharomyces cerevisiae.

1988 • 242 citations

Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase

1992 • 235 citations

Proteasomes (multi-protease complexes) as 20 S ring-shaped particles in a variety of eukaryotic cells.

1988 • 225 citations

Transcriptional Regulation in the Yeast Life Cycle

1987 • 196 citations

Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4

1992 • 196 citations

Subunit stoichiometry and three-dimensional arrangement in proteasomes from Thermoplasma acidophilum.

1992 • 180 citations

Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family

1992 • 171 citations

New human gene encoding a positive modulator of HIV Tat-mediated transactivation

1992 • 163 citations

The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis.

1993 • 149 citations

Turnover of Yeast Fructose-Bisphosphatase in Different Metabolic Conditions

1980 • 147 citations

In vivo function of the proteasome in the ubiquitin pathway.

1992 • 144 citations

Regulation of fructose-1,6-bisphosphatase in yeast by phosphorylation/dephosphorylation

1981 • 144 citations

Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51.

1992 • 142 citations

ATP‐dependent reversible association of proteasomes with multiple protein components to form 26S complexes that degrade ubiquitinated proteins in human HL‐60 cells

1991 • 141 citations

Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits.

1990 • 127 citations

The type 1 human immunodeficiency virus Tat binding protein is a transcriptional activator belonging to an additional family of evolutionarily conserved genes.

1993 • 121 citations

PRE5 and PRE6, the Last Missing Genes Encoding 20S Proteasome Subunits from Yeast? Indication for a Set of 14 Different Subunits in the Eukaryotic Proteasome Core

1994 • 121 citations

Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex

1994 • 117 citations

Molecular cloning and functional analysis of three subunits of yeast proteasome.

1991 • 97 citations

Evidence Indicating that the Human Proteasome is a Complex Dimer

1993 • 97 citations

Tracing intracellular proteolytic pathways. Proteolysis of fatty acid synthase and other cytoplasmic proteins in the yeast Saccharomyces cerevisiae.

1993 • 87 citations

Peptide sequencing identifies MSS1, a modulator of HIV Tat‐mediated transactivation, as subunit 7 of the 26 S protease

1993 • 84 citations

Antizyme, a protein induced by polyamines, accelerates the degradation of ornithine decarboxylase in Chinese-hamster ovary-cell extracts

1992 • 82 citations

PRE3, highly homologous to the human major histocompatibility complex‐linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl‐peptide hydrolyzing activity

1994 • 80 citations

The proteasome/multicatalytic—multifunctional proteinase In vivo function in the ubiquitin‐dependent N‐end rule pathway of protein degradation in eukaryotes

1992 • 76 citations

Proteolysis in eukaryotic cells. Proteinase yscE, a new yeast peptidase.

1984 • 76 citations

Proteasomes from Dictyostelium discoideum: Characterization of Structure and Function

1993 • 74 citations

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome)

1990 • 67 citations

Proteinase yscE of yeast shows homology with the 20 S cylinder particles of Xenopus laevis

1988 • 66 citations

The major‐histocompatibility‐complex‐encoded β‐type proteasome subunits LMP2 and LMP7

1993 • 61 citations

Degradation of the yeast MATα2 transcriptional regulator is mediated by the proteasome

1994 • 61 citations

N‐Terminal sequence similarities between components of the multicatalytic proteinase complex

1990 • 56 citations

Ultrastructure of the approximately 26S complex containing the approximately 20S cylinder particle (multicatalytic proteinase/proteasome).

1991 • 54 citations

Proteasome and cell cycle

1993 • 50 citations

The 26S proteasome of the yeast Saccharomyces cerevisiae

1994 • 42 citations

Separation of yeast proteasome subunits

1989 • 40 citations

The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing

1993 • 40 citations

Tat-Bindung Protein 7 is a Subunit of the 26S Protease

1994 • 39 citations

Nucleotide sequence ofPUP1encoding a putative proteasome subunit inSaccharomyces cerevisiae

1991 • 33 citations

Identification and localization of a cysteinyl residue critical for the trypsin-like catalytic activity of the proteasome

1992 • 32 citations

PRS3 encoding an essential subunit of yeast proteasomes homologous to mammalian proteasome subunit C5

1992 • 29 citations

Involvement of the 20S proteasome in the degradation of ornithine decarboxylase

1993 • 29 citations

Molecular Cloning and Functional Analysis of Three Subunits of Yeast Proteasome

1991 • 28 citations

A 70‐kDa heat shock cognate protein suppresses the defects caused by a proteasome mutation in Saccharomyces cerevisiae

1994 • 28 citations

Molecular cloning of an essential yeast gene encoding a proteasomal subunit

1992 • 27 citations

The 20S proteasome mediates the degradation of mouse and yeast ornithine decarboxylase in yeast cells

1994 • 26 citations

Mutations in PRG1, a yeast proteasome-related gene, cause defects in nuclear division and are suppressed by deletion of a mitotic cyclin gene.

1994 • 25 citations

The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth

1989 • 16 citations

A homolog of the proteasome-related RING10 gene is essential for yeast cell growth

1992 • 14 citations