Evidence for an Interaction between Ubiquitin-Conjugating Enzymes and the 26S Proteasome

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly

1999 • 1,031 citations

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 • 960 citations

A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3

1998 • 901 citations

A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal

1995 • 804 citations

A 26 S protease subunit that binds ubiquitin conjugates.

1994 • 759 citations

Rad6-Dependent Ubiquitination of Histone H2B in Yeast

2000 • 662 citations

Regulation of ubiquitin‐dependent processes by deubiquitinating enzymes

1997 • 576 citations

The ubiquitin system

1997 • 541 citations

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.

1990 • 520 citations

The Regulatory Particle of the Saccharomyces cerevisiae Proteasome

1998 • 487 citations

Rad23 links DNA repair to the ubiquitin/proteasome pathway

1998 • 452 citations

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

1997 • 451 citations

Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor

1993 • 397 citations

The Multiubiquitin-Chain-Binding Protein Mcb1 Is a Component of the 26S Proteasome in Saccharomyces cerevisiae and Plays a Nonessential, Substrate-Specific Role in Protein Turnover

1996 • 393 citations

The recognition component of the N-end rule pathway.

1990 • 388 citations

Targeting of substrates to the 26S proteasome

1997 • 362 citations

Ump1p Is Required for Proper Maturation of the 20S Proteasome and Becomes Its Substrate upon Completion of the Assembly

1998 • 316 citations

Yeast DNA Repair Proteins Rad6 and Rad18 Form a Heterodimer That Has Ubiquitin Conjugating, DNA Binding, and ATP Hydrolytic Activities

1997 • 297 citations

Ubiquitin as a degradation signal.

1992 • 261 citations

The RAD6 protein of Saccharomyces cerevisiae polyubiquitinates histones, and its acidic domain mediates this activity.

1988 • 196 citations

Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells

1990 • 184 citations

The ubiquitin pathway for protein degradation

1991 • 170 citations

Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functions.

1990 • 155 citations

Arabidopsis MBP1 gene encodes a conserved ubiquitin recognition component of the 26S proteasome.

1996 • 143 citations

Interaction of the Doa4 Deubiquitinating Enzyme with the Yeast 26S Proteasome

1999 • 126 citations

Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme.

1991 • 115 citations

Inhibition of Ubiquitin-mediated Proteolysis by the Arabidopsis 26 S Protease Subunit S5a

1995 • 90 citations

Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets

1999 • 82 citations

Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae

1998 • 58 citations

Mammalian Sug1 and c-Fos in the nuclear 26S proteasome.

1996 • 56 citations

Interaction of phosducin and phosducin isoforms with a 26S proteasomal subunit, SUG1.

1998 • 34 citations

Growth-Dependent Change of the 26S Proteasome in Budding Yeast

1998 • 27 citations

Phosducin-like protein (PhLP), a regulator of Gβγ function, interacts with the proteasomal protein SUG1

1998 • 18 citations

Reconstituting Ubiquitination Reactions with Affinity-Purified Components and32P-Ubiquitin

1998 • 17 citations

Characterization of a Temperature-Sensitive Mutant of a Ubiquitin-Conjugating Enzyme and Its Use as a Heat-Inducible Degradation Signal

1999 • 14 citations