Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution

1995 • 1,513 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

γ-Interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

1993 • 572 citations

Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

1996 • 523 citations

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

1995 • 496 citations

Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid.

1986 • 437 citations

S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase

1993 • 422 citations

Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation

1997 • 388 citations

Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.

1994 • 314 citations

The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria

1989 • 277 citations

Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase

1992 • 235 citations

HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome.

1996 • 229 citations

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.

1993 • 215 citations

Sequence analysis of four new heat-shock genes constituting the hslTS/ibpAB and hslVU operons in Escherichia coli

1993 • 162 citations

Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-I antigen-processing pathway.

1995 • 99 citations

Identification of a fourth class of proteins linked to the murine major histocompatibility complex.

1982 • 87 citations

Proteasome sequences in eubacteria

1994 • 67 citations

Immunolocalization of a specific type of prosome close to the bile canaliculi in fetal and adult rat liver.

1992 • 21 citations

Molecular and serological analysis of polymorphisms in the murine major histocompatibility complex-encoded proteasome subunits, LMP-2 and LMP-7.

1996 • 20 citations

Two‐Dimensional Gel Electrophoresis

1998 • 19 citations