Overexpression of the Proteasome Subunits LMP2, LMP7, and MECL-1, But Not PA28α/β, Enhances the Presentation of an Immunodominant Lymphocytic Choriomeningitis Virus T Cell Epitope

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Structure of 20S proteasome from yeast at 2.4Å resolution

1997 • 2,211 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

The Active Sites of the Eukaryotic 20 S Proteasome and Their Involvement in Subunit Precursor Processing

1997 • 506 citations

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

1991 • 460 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid.

1986 • 437 citations

Immunoproteasome Assembly: Cooperative Incorporation of Interferon γ (IFN-γ)–inducible Subunits

1998 • 430 citations

Lymphocytic Choriomeningitis Virus

2016 • 423 citations

Processing of Some Antigens by the Standard Proteasome but Not by the Immunoproteasome Results in Poor Presentation by Dendritic Cells

2000 • 418 citations

Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation

1997 • 388 citations

LacZ inducible, antigen/MHC-specific T cell hybrids

1994 • 377 citations

A role for the proteasome regulator PA28α in antigen presentation

1996 • 341 citations

Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1

1998 • 318 citations

Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.

1994 • 314 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

1992 • 250 citations

The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro

1995 • 233 citations

Peptide antigen production by the proteasome: complexity provides efficiency

1996 • 228 citations

Two families of GTPases dominate the complex cellular response to IFN-gamma.

1998 • 221 citations

Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

1992 • 215 citations

The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome

1997 • 208 citations

Two Families of GTPases Dominate the Complex Cellular Response to IFN-γ

1998 • 197 citations

Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit.

1996 • 196 citations

Primary structures of two homologous subunits of PA28, a γ‐interferon‐inducible protein activator of the 20S proteasome

1995 • 196 citations

Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.

1996 • 195 citations

Structure of the proteasome activator REGα (PA28α)

1997 • 187 citations

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

1998 • 179 citations

A third interferon‐γ‐induced subunit exchange in the 20S proteasome

1996 • 168 citations

PA28 Activator Protein Forms Regulatory Caps on Proteasome Stacked Rings

1994 • 167 citations

Incorporation of major histocompatibility complex – encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon‐γ

1995 • 167 citations

Characterization of Recombinant REGα, REGβ, and REGγ Proteasome Activators

1997 • 164 citations

Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum.

1995 • 163 citations

Efficient Generation of a Hepatitis B Virus Cytotoxic T Lymphocyte Epitope Requires the Structural Features of Immunoproteasomes

2000 • 161 citations

Major histocompatibility complex – dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease

1989 • 140 citations

Bovine Spleen Multicatalytic Proteinase Complex (Proteasome)

1997 • 133 citations

The proteasome‐specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

1997 • 129 citations

Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport

1995 • 129 citations

Discrete Proteolytic Intermediates in the MHC Class I Antigen Processing Pathway and MHC I–Dependent Peptide Trimming in the ER

1999 • 123 citations

Specificity of the proteasome and the TAP transporter

1999 • 113 citations

Proteasome Activator 11S REG or PA28: Recombinant REGα/REGβ Hetero-oligomers Are Heptamers¹

1999 • 110 citations

The Selective Proteasome Inhibitors Lactacystin and Epoxomicin Can Be Used to Either Up- or Down-Regulate Antigen Presentation at Nontoxic Doses

2000 • 106 citations

Analysis of the fine specificity of rat, mouse and human TAP peptide transporters

1995 • 102 citations

LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes

1995 • 97 citations

MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation.

1994 • 94 citations

Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon

1994 • 89 citations

Potential Immunocompetence of Proteolytic Fragments Produced by Proteasomes before Evolution of the Vertebrate Immune System

1997 • 87 citations

Lymphocytic choriomeningitis virus. VI. Isolation of a glycoprotein mediating neutralization

1983 • 83 citations

Generation of an Immunodominant CTL Epitope Is Affected by Proteasome Subunit Composition and Stability of the Antigenic Protein

1999 • 77 citations

Relative Functions of the α and β Subunits of the Proteasome Activator, PA28

1997 • 74 citations

Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomeningitis virus‐infected mice with anti‐interferon‐γ monoclonal antibody blocks generation of virus‐specific cytotoxic T lymphocytes and virus elimination

1989 • 71 citations

Mechanism of recovery from acute virus infection

1985 • 69 citations

Expression and subcellular localization of mouse 20S proteasome activator complex PA28

1997 • 67 citations

Molecular cloning of the mouse proteasome subunits MC14 and MECL‐1: reciprocally regulated tissue expression of interferon‐γ‐modulated proteasome subunits

1997 • 67 citations

IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase.

1999 • 58 citations

Inactivation of a Defined Active Site in the Mouse 20S Proteasome Complex Enhances Major Histocompatibility Complex Class I Antigen Presentation of a Murine Cytomegalovirus Protein

1998 • 55 citations

IFN-γ Exposes a Cryptic Cytotoxic T Lymphocyte Epitope in HIV-1 Reverse Transcriptase

1999 • 51 citations

Low-Affinity Cytotoxic T-Lymphocytes Require IFN-γ to Clear an Acute Viral Infection

1997 • 45 citations

Contribution of Proline Residue for Efficient Production of MHC Class I Ligands by Proteasomes

1998 • 45 citations

Newly Identified Pair of Proteasomal Subunits Regulated Reciprocally by Interferon γ

1997 • 39 citations

Presentation of viral antigens restricted by H‐2K^b, D^b or K^d in proteasome subunit LMP2‐and LMP7‐deficient cells

1994 • 38 citations

Reactions of [¹⁴C]-3,4-Dichloroisocoumarin with Subunits of Pituitary and Spleen Multicatalytic Proteinase Complexes (Proteasomes)

1997 • 37 citations

Mutational analysis of subunit iβ2 (MECL‐1) demonstrates conservation of cleavage specificity between yeast and mammalian proteasomes

1999 • 33 citations

The Proteasome Activator 11 S Regulator or PA28

1998 • 29 citations

The proteasome inhibitor lactacystin prevents the generation of an endoplasmic reticulum leader—derived T cell epitope

1998 • 20 citations

Lymphocytic Choriomeningitis Virus

1971 • 12 citations

Characterization of Recombinant REGa, REGb, and REGg Proteasome Activators*

1997 • 7 citations