A Phagosome-to-Cytosol Pathway for Exogenous Antigens Presented on MHC Class I Molecules

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

1985 • 789 citations

TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells

1992 • 726 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

1993 • 592 citations

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

1982 • 576 citations

Proteolysis, proteasomes and antigen presentation

1992 • 576 citations

Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

1979 • 522 citations

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

1990 • 414 citations

Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter

1991 • 413 citations

Cell Biology of Antigen Processing and Presentation to Major Histocompatibility Complex Class I Molecule-Restricted T Lymphocytes

1992 • 373 citations

CD8+ T lymphocytes in intracellular microbial infections

1988 • 335 citations

Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes

1989 • 329 citations

Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A.

1980 • 321 citations

Cytotoxic T lymphocytes against a soluble protein

1987 • 178 citations

TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but not carboxyl-terminus of the peptide.

1994 • 147 citations

Purified immunotoxins that are reactive with human lymphoid cells. Monoclonal antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins.

1985 • 138 citations

The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism

1986 • 122 citations

The transporters associated with antigen presentation

1993 • 118 citations

Presentation of exogenous antigens by macrophages: analysis of major histocompatibility complex class I and II presentation and regulation by cytokines

1994 • 107 citations

Vacuolar/lysosomal proteolysis: proteases, substrates mechanisms

1993 • 97 citations

Generation of class I MHC-restricted T-T hybridomas.

1990 • 85 citations

The involvement of herpes simplex virus type 1 glycoproteins in cell-mediated immunity.

1981 • 81 citations

Presentation of Listeria monocytogenes antigens by major histocompatibility complex class I molecules to CD8 cytotoxic T lymphocytes independent of listeriolysin secretion and virulence

1994 • 40 citations