p53-dependent Induction of Apoptosis by Proteasome Inhibitors

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

The molecular biology of apoptosis.

1996 • 963 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

1994 • 723 citations

Regulators of cell death

1995 • 647 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

1983 • 356 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

Proteasomes play an essential role in thymocyte apoptosis.

1996 • 316 citations

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

1996 • 262 citations

Selective protein degradation: A journey's end within the proteasome

1995 • 259 citations

Lactacystin, a Specific Inhibitor of the Proteasome, Induces Apoptosis in Human Monoblast U937 Cells

1995 • 214 citations

A New Inhibitor of the Chymotrypsin‐Like Activity of the Multicatalytic Proteinase Complex (20S Proteasome) Induces Accumulation of Ubiquitin‐Protein Conjugates in a Neuronal Cell

1994 • 183 citations