Ubiquitin‐dependent internalization and down‐regulation of plasma membrane proteins

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.

1996 • 1,161 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

A 26 S protease subunit that binds ubiquitin conjugates.

1994 • 759 citations

A Ubiquitin Mutant with Specific Defects in DNA Repair and Multiubiquitination

1995 • 547 citations

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains

1992 • 540 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

1996 • 450 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.

1994 • 361 citations

Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification.

1993 • 349 citations

Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant.

1994 • 347 citations

Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization.

1995 • 343 citations

NPI1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin—protein ligase

1995 • 331 citations

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.

1994 • 319 citations

The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain

1988 • 317 citations

Ubiquitination Mediated by the Npi1p/Rsp5p Ubiquitin-protein Ligase Is Required for Endocytosis of the Yeast Uracil Permease

1996 • 316 citations

Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components.

1996 • 314 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling.

1995 • 290 citations

Protein Degradation or Regulation: Ub the Judge

1996 • 275 citations

Eps15 Is a Component of Clathrin-coated Pits and Vesicles and Is Located at the Rim of Coated Pits

1996 • 266 citations

Endocytosis and degradation of the yeast uracil permease under adverse conditions

1994 • 266 citations

eps15, a novel tyrosine kinase substrate, exhibits transforming activity.

1993 • 265 citations

The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.

1994 • 260 citations

Stress resistance in Saccharomyces cerevisiae is strongly correlated with assembly of a novel type of multiubiquitin chain.

1994 • 238 citations

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.

1994 • 228 citations

Degradation of the Met Tyrosine Kinase Receptor by the Ubiquitin-Proteasome Pathway

1997 • 221 citations

A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15.

1996 • 217 citations

Activation-Induced Ubiquitination of the T Cell Antigen Receptor

1992 • 213 citations

Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.

1995 • 213 citations

ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

1997 • 190 citations

The tyrosine kinase substrate eps15 is constitutively associated with the plasma membrane adaptor AP-2.

1995 • 183 citations

Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.

1992 • 173 citations

Ubiquitination of the yeast a-factor receptor.

1996 • 172 citations

Transcriptional and posttranslational regulation of the general amino acid permease of Saccharomyces cerevisiae

1995 • 161 citations

Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C.

1994 • 157 citations

Signal Propagation and Regulation in the Mating Pheromone Response Pathway of the Yeast Saccharomyces cerevisiae

1994 • 157 citations

Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.

1993 • 155 citations

Endocytosis and Lysosomal Targeting of Epidermal Growth Factor Receptors Are Mediated by Distinct Sequences Independent of the Tyrosine Kinase Domain

1995 • 151 citations

Structure of Tetraubiquitin Shows How Multiubiquitin Chains Can Be Formed

1994 • 151 citations

Suppressors of YCK-encoded yeast casein kinase 1deficiency define the four subunits of a novel clathrin AP-like complex

1997 • 147 citations

Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention.

1994 • 144 citations

A uniform isopeptide-linked multiubiquitin chain is sufficient to target substrate for degradation in ubiquitin-mediated proteolysis.

1990 • 136 citations

Ubiquitinated histone H2B is preferentially located in transcriptionally active chromatin

1989 • 136 citations

The epidermal growth factor receptor is covalently linked to ubiquitin.

1995 • 130 citations

Endocytosis and Vacuolar Degradation of the Plasma Membrane-Localized Pdr5 ATP-Binding Cassette Multidrug Transporter in Saccharomyces cerevisiae

1995 • 129 citations

A Conserved NPLFY Sequence Contributes to Agonist Binding and Signal Transduction but Is Not an Internalization Signal for the Type 1 Angiotensin II Receptor

1995 • 127 citations

Identification of a novel sequence mediating regulated endocytosis of the G protein-coupled alpha-pheromone receptor in yeast.

1993 • 126 citations

Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines.

1994 • 125 citations

The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole

1996 • 124 citations

Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors.

1993 • 119 citations

Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells

1994 • 119 citations

Angiotensin II Receptor Endocytosis Involves Two Distinct Regions of the Cytoplasmic Tail

1995 • 113 citations

The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae.

1996 • 109 citations

Molecular Aspects of Transport Proteins

1992 • 109 citations

Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells

1990 • 105 citations

Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae.

1994 • 102 citations

Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling.

1993 • 102 citations

Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor

1997 • 100 citations

Characterization of the glucose-induced inactivation of maltose permease in Saccharomyces cerevisiae

1996 • 88 citations

T Cell Antigen Receptor Ubiquitination Is a Consequence of Receptor-mediated Tyrosine Kinase Activation

1996 • 83 citations

Ubiquitinylation and Ubiquitin-dependent Proteolysis in Vertebrate Photoreceptors (Rod Outer Segments)

1996 • 83 citations

Catabolite inactivation of the yeast maltose transporter requires ubiquitin-ligase npi1/rsp5 and ubiquitin-hydrolase npi2/doa4

2006 • 64 citations

Ligand-Induced Polyubiquitination of Receptor Tyrosine Kinases

1995 • 58 citations

The Yeast Plasma Membrane Uracil Permease Is Stabilized against Stress-Induced Degradation by a Point Mutation in a Cyclin-like "Destruction Box"

1994 • 44 citations

Agonist-Specific Conformational Changes in the Yeast α-Factor Pheromone Receptor

1996 • 42 citations

Membrane topology of the yeast uracil permease

1996 • 30 citations

Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease.

1997 • 23 citations