Two new proteases in the MHC class I processing pathway

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

Cellular peptide composition governed by major histocompatibility complex class I molecules

1990 • 438 citations

A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

1999 • 377 citations

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase

1998 • 297 citations

Coordinated Dual Cleavages Induced by the Proteasome Regulator PA28 Lead to Dominant MHC Ligands

1996 • 287 citations

Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide

1997 • 267 citations

Trimming of antigenic peptides in an early secretory compartment.

1994 • 169 citations

Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

1996 • 168 citations

Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum.

1995 • 163 citations

Puromycin-sensitive Aminopeptidase

1995 • 161 citations

The proteasome‐specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

1997 • 129 citations

Proteasomes Can Either Generate or Destroy MHC Class I Epitopes: Evidence for Nonproteasomal Epitope Generation in the Cytosol

1998 • 124 citations

Discrete Proteolytic Intermediates in the MHC Class I Antigen Processing Pathway and MHC I–Dependent Peptide Trimming in the ER

1999 • 123 citations

The Human 26 S and 20 S Proteasomes Generate Overlapping but Different Sets of Peptide Fragments from a Model Protein Substrate

2000 • 116 citations

Solubilization and characterization of two rat brain membrane-bound aminopeptidases active on Met-enkephalin

1981 • 110 citations

Human Bleomycin Hydrolase: Molecular Cloning, Sequencing, Functional Expression, and Enzymatic Characterization

1996 • 107 citations

A BLEOMYCIN-INACTIVATING ENZYME IN MOUSE LIVER

1974 • 99 citations

BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase.

1993 • 80 citations

Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities

1998 • 78 citations

Studies on the Tissue Distribution of the Puromycin‐Sensitive Enkephalin‐Degrading Aminopeptidases

1988 • 74 citations

Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease

1999 • 71 citations

Dissociation of Proteasomal Degradation of Biosynthesized Viral Proteins from Generation of MHC Class I-Associated Antigenic Peptides

1998 • 64 citations

The protease inhibitor, N-acetyl-L-leucyl-L-leucyl-leucyl-L-norleucinal, decreases the pool of major histocompatibility complex class I-binding peptides and inhibits peptide trimming in the endoplasmic reticulum.

1996 • 63 citations

Selective involvement of proteasomes and cysteine proteases in MHC class I antigen presentation.

1997 • 52 citations

Sequential Cleavage by Metallopeptidases and Proteasomes Is Involved in Processing HIV-1 ENV Epitope for Endogenous MHC Class I Antigen Presentation

2000 • 36 citations

Cloning and Analysis of the Gene for the Human Puromycin-Sensitive Aminopeptidase

1999 • 33 citations

Essential Binding and Functional Domains of Human Bleomycin Hydrolase

1998 • 32 citations

Gene Characterization, Promoter Analysis, and Chromosomal Localization of Human Bleomycin Hydrolase

1997 • 30 citations

An Evolutionarily Conserved Cysteine Protease, Human Bleomycin Hydrolase, Binds to the Human Homologue of Ubiquitin-Conjugating Enzyme 9

1998 • 27 citations

Proteolytic processing of peptides in the lumen of the endoplasmic reticulum for antigen presentation by major histocompatibility class I

2000 • 26 citations

An enkephalin degrading aminopeptidase of human brain preserved during the vertebrate phylogeny

1991 • 3 citations