Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.

1985 • 3,185 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

1995 • 561 citations

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.

1993 • 483 citations

Cut2 proteolysis required for sister-chromatid separation in fission yeast

1996 • 451 citations

Cyclin Ubiquitination: The destructive end of mitosis

1995 • 304 citations

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

1995 • 286 citations

The role of cyclin B in meiosis I.

1989 • 241 citations

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

1994 • 235 citations

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.

1995 • 201 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation

1996 • 180 citations

Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functions.

1990 • 155 citations

Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development

1995 • 155 citations

E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.

1996 • 141 citations

TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast.

1996 • 112 citations

Cloning of a 16-kDa ubiquitin carrier protein from wheat and Arabidopsis thaliana. Identification of functional domains by in vitro mutagenesis.

1991 • 94 citations

The self-destructive personality of a cell cycle in transition

1995 • 64 citations

Stable ester conjugate between the Saccharomyces cerevisiae RAD6 protein and ubiquitin has no biological activity

1991 • 58 citations

Expression of N-terminally truncated cyclin B in the Drosophila larval brain leads to mitotic delay at late anaphase

1994 • 52 citations

Characterization of a Dominant Negative Mutant of the Cell Cycle Ubiquitin-conjugating Enzyme Cdc34

1995 • 44 citations

Mutation of the bovine papillomavirus E5 oncoprotein at amino acid 17 generates both high- and low-transforming variants

1994 • 43 citations

Delayed cyclin A and B1 degradation in non-transformed mammalian cells

1995 • 25 citations