Purification of an 11 S regulator of the multicatalytic protease.

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Purification of two high molecular weight proteases from rabbit reticulocyte lysate.

1987 • 542 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

1989 • 370 citations

Evidence that Pituitary Cation‐Sensitive Neutral Endopeptidase Is a Multicatalytic Protease Complex

1983 • 356 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

Intracellular Calcium-Dependent Proteolysis

2019 • 286 citations

Calcium‐activated neutral protease and its endogenous inhibitor Activation at the cell membrane and biological function

1987 • 273 citations

The multicatalytic proteinase of mammalian cells

1989 • 242 citations

Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase

1992 • 235 citations

Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate.

1992 • 229 citations

Proteasomes (multi-protease complexes) as 20 S ring-shaped particles in a variety of eukaryotic cells.

1988 • 225 citations

Macroxyproteinase (M.O.P.): A 670 kDa Proteinase complex that degrades oxidatively denatured proteins in red blood cells

1989 • 182 citations

Electron microscopy and image analysis of the multicatalytic proteinase

1988 • 150 citations

The Multicatalytic Proteinase

1989 • 145 citations

Microinjection of ubiquitin: changes in protein degradation in HeLa cells subjected to heat-shock.

1987 • 145 citations

ATP‐dependent reversible association of proteasomes with multiple protein components to form 26S complexes that degrade ubiquitinated proteins in human HL‐60 cells

1991 • 141 citations

Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits.

1990 • 127 citations

A multicatalytical protease complex from pituitary that forms enkephalin and enkephalin containing peptides

1981 • 122 citations

Ubiquitin-lysozyme conjugates. Purification and susceptibility to proteolysis.

1986 • 108 citations

Purification and characterization of a high molecular weight proteinase (macropain) from human erythrocytes

1986 • 107 citations

Binding of calpain fragments to calpastatin

1991 • 100 citations

Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome)

1991 • 99 citations

Molecular cloning and functional analysis of three subunits of yeast proteasome.

1991 • 97 citations

Calcium activated neutral protease. - Structure-function relationship and functional implications.

1990 • 96 citations

Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity.

1990 • 92 citations

Kinetic studies of the differential effect of detergents on the peptidase activities of the multicatalytic proteinase from rat liver.

1990 • 89 citations

The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome.

1989 • 89 citations

Limited Autolysis of Calcium-Activated Neutral Protease (CANP): Reduction of the Ca2+-Requirement Is Due to the NK2-Tenninal Processing of the Large Subunit1

1986 • 87 citations

Molecular cloning of cDNA for proteasomes (multicatalytic proteinase complexes) from rat liver: primary structure of the largest component (C2)

1989 • 86 citations

Identification and partial purification of a factor that stimulates calcium-dependent proteases

1982 • 81 citations

Size and shape of the multicatalytic proteinase from rat skeletal muscle

1986 • 73 citations

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome)

1990 • 67 citations

An endogenous activator of the Ca2+-dependent proteinase of human neutrophils that increases its affinity for Ca2+.

1988 • 57 citations

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous

1991 • 56 citations

The Drosophila PROS-28.1 gene is a member of the proteasome gene family

1990 • 54 citations

Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex

1991 • 53 citations

Isolation and characterization of a novel endogenous inhibitor of the proteasome

1991 • 52 citations

Proteasome and its novel endogeneous activator in human platelets

1991 • 49 citations

Purification of a protease in red blood cells that degrades oxidatively damaged haemoglobin

1991 • 49 citations

cDNA cloning and sequencing of component C5 of proteasomes from rat hepatoma cells

1990 • 48 citations

Characterization of the active site of human multicatalytic proteinase

1990 • 47 citations

A calcium‐protease activator associated with brain microsomal‐insoluble elements

1986 • 46 citations

Endogenous inhibitor of nonlysosomal high molecular weight protease and calcium-dependent protease.

1986 • 44 citations

The Drosophila PROS-29 gene is a new member of the PROS-gene family

1990 • 32 citations

Chemical modification of the bovine pituitary multicatalytic proteinase complex by N-acetylimidazole. Reversible activation of casein hydrolysis.

1991 • 30 citations

PRS3 encoding an essential subunit of yeast proteasomes homologous to mammalian proteasome subunit C5

1992 • 29 citations

Molecular cloning of cDNAs for two subunits of rat multicatalytic proteinase

1990 • 18 citations

Purification and characterization of a calpain activator from human platelets

1992 • 18 citations