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The bioactive phospholipid lysophosphatidic acid is released from activated platelets

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LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing

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1998 • 535 citations

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Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

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Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

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Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

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Requirement for the lp _A1 lysophosphatidic acid receptor gene in normal suckling behavior

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GPR92 as a New G12/13- and Gq-coupled Lysophosphatidic Acid Receptor That Increases cAMP, LPA5

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Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid

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Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways

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Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer

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G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

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The Sphingosine-1-phosphate Receptors S1P1, S1P2, and S1P3 Function Coordinately during Embryonic Angiogenesis

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A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

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G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation

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Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer

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Lysophospholipids Are Potential Biomarkers of Ovarian Cancer

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1995 • 325 citations

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

2000 • 323 citations

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Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

2001 • 318 citations

Characterization of lpa₂ (Edg4) and lpa₁/lpa₂ (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa₂

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Mechanisms of lysophosphatidic acid production

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Lysophospholipids activate ovarian and breast cancer cells

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Lysophospholipid G Protein-coupled Receptors

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A single receptor encoded by vzg-1 / lp _A1 / edg- 2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid

1998 • 280 citations

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

1996 • 280 citations

Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis

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Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPB3/EDG-3

2001 • 271 citations

Evidence for a Role for Prostaglandins in the Initiation of Blastocyst Implantation in the Rat1

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Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

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Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood

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Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid

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Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

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Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding

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Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer

2004 • 246 citations

Cytosolic phospholipase A2α is crucial for ‘on-time’ embryo implantation that directs subsequent development

2002 • 244 citations

G2A Is a Proton-sensing G-protein-coupled Receptor Antagonized by Lysophosphatidylcholine

2004 • 241 citations

Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3

2002 • 241 citations

Emerging medicinal roles for lysophospholipid signaling

2006 • 240 citations

Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes

2006 • 230 citations

Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

2002 • 228 citations

Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice

2004 • 221 citations

The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor

2007 • 220 citations

Lysophosphatidic Acid and Sphingosine 1-Phosphate Protection of T Cells from Apoptosis in Association with Suppression of Bax

1999 • 219 citations

Uterine Wnt/β-catenin signaling is required for implantation

2005 • 214 citations

Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

1993 • 210 citations

Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction

2002 • 209 citations

Molecular Cloning and Characterization of a Lysophosphatidic Acid Receptor, Edg-7, Expressed in Prostate

2000 • 206 citations

The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases

2006 • 205 citations

Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors

2002 • 201 citations

Sphingosine Kinase-1 as a Chemotherapy Sensor in Prostate Adenocarcinoma Cell and Mouse Models

2005 • 198 citations

A Novel Phosphatidic Acid-selective Phospholipase A1That Produces Lysophosphatidic Acid

2002 • 198 citations

Lysophosphatidic acid synthesis and release

2001 • 198 citations

The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes

2005 • 195 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1998 • 195 citations

Generation and metabolism of bioactive sphingosine‐1‐phosphate

2004 • 194 citations

Deafness and Stria Vascularis Defects in S1P2 Receptor-null Mice

2007 • 191 citations

Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.

2002 • 191 citations

Mechanisms for Lysophosphatidic Acid-induced Cytokine Production in Ovarian Cancer Cells

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Sphingosine 1-phosphate: synthesis and release

2001 • 187 citations

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin

1989 • 185 citations

An essential role for the H218/AGR16/Edg‐5/LP_B2 sphingosine 1‐phosphate receptor in neuronal excitability

2001 • 182 citations

Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

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Lysophospholipids and their G protein-coupled receptors in inflammation and immunity

2002 • 179 citations

Malignant effusions contain lysophosphatidic acid (LPA)-like activity

1998 • 178 citations

Lysophosphatidic Acid (LPA) in Malignant Ascites Stimulates Motility of Human Pancreatic Cancer Cells through LPA1

2004 • 176 citations

EDG3 Is a Functional Receptor Specific for Sphingosine 1-Phosphate and Sphingosylphosphorylcholine with Signaling Characteristics Distinct from EDG1 and AGR16

1999 • 176 citations

Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6

2000 • 174 citations

Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.

2000 • 172 citations

Lysophosphatidic Acid (LPA) Is a Novel Extracellular Regulator of Cortical Neuroblast Morphology

2000 • 170 citations

Regulation of Schwann Cell Morphology and Adhesion by Receptor-Mediated Lysophosphatidic Acid Signaling

2001 • 169 citations

LPA4/GPR23 Is a Lysophosphatidic Acid (LPA) Receptor Utilizing Gs-, Gq/Gi-mediated Calcium Signaling and G12/13-mediated Rho Activation

2006 • 169 citations

Lysophosphatidic acids. Influence on platelet aggregation and intracellular calcium flux.

1979 • 169 citations

Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis

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Phosphatidic and lysophosphatidic acid production in phospholipase C-and thrombin-treated platelets. possible involvement of a platelet lipase

1978 • 166 citations

Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma

1986 • 165 citations

Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species

1978 • 164 citations

Serum-regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain.

1994 • 162 citations

Involvement of a Pertussis Toxin-sensitive G Protein in the Mitogenic Signaling Pathways of Sphingosine 1-Phosphate

1995 • 161 citations

Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration

2005 • 160 citations

Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner

2005 • 157 citations

Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate

2002 • 154 citations

Edg-6 as a Putative Sphingosine 1-Phosphate Receptor Coupling to Ca2+ Signaling Pathway

2000 • 154 citations

Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors.

2001 • 153 citations

Development of Our Current Understanding of Bioactive Lysophospholipids

2000 • 151 citations

The structure and functions of human lysophosphatidic acid acyltransferases

2001 • 148 citations

Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.

1999 • 147 citations

Cerebral Amyloid Angiopathy: Accumulation of Aβ in Interstitial Fluid Drainage Pathways in Alzheimer's Disease

2000 • 146 citations

Sphingosine-1-phosphate receptors and the development of the vascular system

2002 • 145 citations

Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice

2007 • 144 citations

Receptors for Protons or Lipid Messengers or Both?

2006 • 143 citations

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P

2006 • 142 citations

Absence of LPA1 Signaling Results in Defective Cortical Development

2007 • 142 citations

Evolution of the brain developmental plan: Insights from agnathans

2005 • 142 citations

Sphingosine Kinase 1 Regulates Differentiation of Human and Mouse Lung Fibroblasts Mediated by TGF-β1

2007 • 140 citations

Phosphorylated FTY720 promotes astrocyte migration through sphingosine‐1‐phosphate receptors

2007 • 136 citations

Lysophosphatidic acid as a novel cell survival/apoptotic factor

2002 • 134 citations

High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation

2006 • 134 citations

Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia

2007 • 132 citations

Platelet Aggregation Evoked In Vitro and In Vivo by Phosphatidic Acids and Lysoderivatives: Identity with Substances in Aged Serum (DAS)

1979 • 129 citations

Production of Lysophosphatidic Acids by Lysophospholipase D in Human Follicular Fluids of In Vitro Fertilization Patients1

1999 • 128 citations

Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells

2007 • 126 citations

S1P₃receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF

2005 • 126 citations

LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease

2003 • 125 citations

Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren

2007 • 124 citations

Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway

2004 • 124 citations

Lysophosphatidic acid, a growth factor-like lipid, in the saliva

2002 • 123 citations

New developments in the biological functions of lysophospholipids

2006 • 122 citations

CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-κB activation

2007 • 122 citations

The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration

2005 • 121 citations

Lysophosphatidic acid prevents apoptosis in fibroblasts via Gi-protein-mediated activation of mitogen-activated protein kinase

2000 • 121 citations

Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids

2002 • 119 citations

LPA4/p2y9/GPR23 Mediates Rho-dependent Morphological Changes in a Rat Neuronal Cell Line

2006 • 117 citations

Lysophospholipids Increase Interleukin-8 Expression in Ovarian Cancer Cells

2001 • 116 citations

Thrombogenic and atherogenic activities of lysophosphatidic acid

2004 • 114 citations

Phorbol 12-Myristate 13-Acetate Stimulates Lysophosphatidic Acid Secretion from Ovarian and Cervical Cancer Cells but Not from Breast or Leukemia Cells

1998 • 113 citations

The roles of sphingosine-1-phosphate in asthma

2002 • 113 citations

Regulation of fibroblast functions by lysophospholipid mediators: Potential roles in wound healing

2007 • 113 citations

Sphingosine 1-Phosphate (S1P) Signaling Is Required for Maintenance of Hair Cells Mainly via Activation of S1P₂

2007 • 112 citations

Embryo Spacing and Implantation Timing Are Differentially Regulated by LPA3-Mediated Lysophosphatidic Acid Signaling in Mice1

2007 • 112 citations

Over-expression of lysophosphatidic acid receptor-2 in human invasive ductal carcinoma

2004 • 110 citations

Induction of Apoptosis in Human Bladder Cancer Cells In Vitro and In Vivo Caused by FTY720 Treatment

2003 • 110 citations

Effect of Insulin on Cell Cycle Progression in MCF-7 Breast Cancer Cells

2001 • 109 citations

Cyclooxygenase-2 Functions as a Downstream Mediator of Lysophosphatidic Acid to Promote Aggressive Behavior in Ovarian Carcinoma Cells

2005 • 109 citations

Targeting sphingosine-1-phosphate: A novel avenue for cancer therapeutics

2006 • 109 citations

Growth factor-like phospholipids generated after corneal injury

1998 • 107 citations

Acid ceramidase is a novel factor required for early embryo survival

2007 • 106 citations

Cloning, Chromosomal Localization, and Tissue Expression of Autotaxin from Human Teratocarcinoma Cells

1996 • 106 citations

Increased Production of Bioactive Lysophosphatidic Acid by Serum Lysophospholipase D in Human Pregnancy1

2002 • 105 citations

Biochemical and Molecular Characterization of Two Phosphatidic Acid-selective Phospholipase A1s, mPA-PLA1α and mPA-PLA1β

2003 • 105 citations

Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells

2006 • 103 citations

FTY720 (fingolimod) in renal transplantation

2006 • 102 citations

Stem cell regulation by lysophospholipids

2007 • 100 citations

FTY720: A Promising Agent for Treatment of Metastatic Hepatocellular Carcinoma

2005 • 97 citations

Lysophosphatidic Acid Receptor-Selective Effects on Jurkat T Cell Migration Through a Matrigel Model Basement Membrane

2001 • 96 citations

Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility

2002 • 95 citations

LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells

2007 • 95 citations

Lysophosphatidic acid‐regulated mitogenic ERK signaling in androgen‐insensitive prostate cancer PC‐3 cells

2002 • 94 citations

Responses to sphingosine-1-phosphate in X. laevis oocytes: similarities with lysophosphatidic acid signaling

1993 • 94 citations

Lysophosphatidic acid production and action: Validated targets in cancer?

2004 • 94 citations

Cancer Treatment and Research

2005 • 93 citations

Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer.

2003 • 93 citations

Sphingosine 1-Phosphate Protects Bovine Oocytes from Heat Shock During Maturation1

2004 • 93 citations

Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF- B pathway by lysophosphatidic acid, an ovarian cancer-activating factor

2004 • 89 citations

TRIP6 Enhances Lysophosphatidic Acid-induced Cell Migration by Interacting with the Lysophosphatidic Acid 2 Receptor

2004 • 89 citations

Critical Role of Lysophospholipids in the Pathophysiology, Diagnosis, and Management of Ovarian Cancer

2002 • 89 citations

Effects of LPA and S1P on the Nervous System and Implications for Their Involvement in Disease

2006 • 88 citations

Lysophosphatidic Acid Is a Major Regulator of Growth-Regulated Oncogene α in Ovarian Cancer

2006 • 87 citations

Lysophosphatidic Acid Induction of Transforming Growth Factors α and β: Modulation of Proliferation and Differentiation in Cultured Human Keratinocytes and Mouse Skin

1995 • 87 citations

Sphingosine‐1‐phosphate modulates growth and adhesion of ovarian cancer cells

1999 • 87 citations

Age-Dependent Loss of Sperm Production in Mice via Impaired Lysophosphatidic Acid Signaling1

2008 • 86 citations

The S1P2 sphingosine 1-phosphate receptor is essential for auditory and vestibular function

2006 • 85 citations

Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation

2004 • 85 citations

Lysophosphatidic acid induces a pertussis toxin-sensitive Ca(2+)-activated Cl- current in Xenopus laevis oocytes

1992 • 84 citations

Pharmacologically active acidic phospholipids and glycolipids

1963 • 84 citations

Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA1, p42 and p38α

2007 • 84 citations

Sphingosine 1‐phosphate and its G protein‐coupled receptors constitute a multifunctional immunoregulatory system

2004 • 83 citations

Sphingosine 1-phosphate protects ovaries from chemotherapy-induced damage in vivo

2006 • 83 citations

Lysophospholipid Receptors: Implications for Neural Signaling

1999 • 83 citations

Mitogenic action of LPA in prostate

2002 • 83 citations

Effect of Progesterone on Bovine Sperm Capacitation and Acrosome Reaction

2003 • 82 citations

Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA‐binding proteins in activation of LPA receptors

2002 • 82 citations

Differential expression of prostaglandin (PG) synthesis enzymes in conceptus during peri-implantation period and endometrial expression of carbonyl reductase/PG 9-ketoreductase in the pig

2007 • 82 citations

A novel laminin‐induced lysophosphatidic acid autocrine loop in the migration of ovarian cancer cells

2003 • 81 citations

Serine Palmitoyltransferase, a Key Enzyme for de Novo Synthesis of Sphingolipids, Is Essential for Male Gametophyte Development in Arabidopsis

2008 • 81 citations

S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells

2007 • 80 citations

Lysophosphatidic acid accelerates the development of human mast cells

2004 • 79 citations

Lysophospholipid Receptors as Potential Drug Targets in Tissue Transplantation and Autoimmune Diseases

2005 • 79 citations

Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis

2005 • 77 citations

Thrombin and Lysophosphatidic Acid Receptors Utilize Distinct rhoGEFs in Prostate Cancer Cells

2004 • 77 citations

Lysophosphatidic acid prevents apoptosis in fibroblasts via Gi-protein-mediated activation of mitogen-activated protein kinase

2000 • 77 citations

Regulation of vascular reactivity by established and emerging GPCRs

2005 • 76 citations

Lysophosphatidic acid stimulates astrocyte proliferation through LPA1

2007 • 75 citations

Protein kinase Cα-CARMA3 signaling axis links Ras to NF-κB for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells

2007 • 74 citations

Lysophosphatidic acid and bFGF control different modes in proliferating myoblasts.

1996 • 74 citations

LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)

2007 • 74 citations

Unfolding the Pathophysiological Role of Bioactive Lysophospholipids

2003 • 73 citations

Follicular Fluid High Density Lipoprotein-associated Sphingosine 1-Phosphate Is a Novel Mediator of Ovarian Angiogenesis

2005 • 72 citations

Lysophosphatidic acid inhibits gap-junctional communication and stimulates phosphorylation of connexin-43 in WB cells: possible involvement of the mitogen-activated protein kinase cascade

1994 • 72 citations

Exogenous Sphingosine 1-Phosphate Induces Neurite Retraction Possibly through a Cell Surface Receptor in PC12 Cells

1997 • 71 citations

Lysophosphatidic acid regulates murine blastocyst development by transactivation of receptors for heparin-binding EGF-like growth factor

2004 • 70 citations

Protection from Radiation-Induced Male Germ Cell Loss by Sphingosine-1-Phosphate1

2004 • 70 citations

Lysophosphatidic Acid Up-Regulates Expression of Interleukin-8 and -6 in Granulosa-Lutein Cells through Its Receptors and Nuclear Factor-κB Dependent Pathways: Implications for Angiogenesis of Corpus Luteum and Ovarian Hyperstimulation Syndrome

2008 • 69 citations

Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin–epithelin precursor (GEP), a prosurvival factor for ovarian cancer

2005 • 69 citations

The G Protein-Coupled Receptor GPR4 Suppresses ERK Activation in a Ligand-Independent Manner

2003 • 69 citations

Secretion of a lysophospholipase D activity by adipocytes: involvement in lysophosphatidic acid synthesis

2002 • 68 citations

Expression and Function of Lysophosphatidic Acid LPA1 Receptor in Prostate Cancer Cells

2006 • 68 citations

Targeting sphingosine-1-phosphate for cancer therapy

2006 • 68 citations

Sphingosine 1-Phosphate in Amniotic Fluid Modulates Cyclooxygenase-2 Expression in Human Amnion-derived WISH Cells

2003 • 67 citations

Effects of Nicotine on Early Pregnancy in the Rat

1979 • 67 citations

Biosynthesis of Phosphatidic Acid, Lysophosphatidic Acid, Diglyceride, and Triglyceride by Fatty Acyltransferase Pathways in Escherichia coli

1967 • 67 citations

The peanut allergy epidemic: allergen molecular characterisation and prospects for specific therapy

2007 • 66 citations

Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans

2003 • 65 citations

Lysophosphatidic Acid Induces Focal Adhesion Assembly through Rho/Rho-Associated Kinase Pathway in Human Ovarian Cancer Cells

2002 • 65 citations

Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level

2003 • 65 citations

Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila

2007 • 65 citations

Lysophospholipase D and its role in LPA production

2004 • 65 citations

Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2)

2004 • 62 citations

Signaling Mechanisms Responsible for Lysophosphatidic Acid-induced Urokinase Plasminogen Activator Expression in Ovarian Cancer Cells

2005 • 60 citations

Purification and Properties of a Phosphatidic Acid-preferring Phospholipase A1 from Bovine Testis

1996 • 60 citations

Role of phospholipase D in agonist-stimulated lysophosphatidic acid synthesis by ovarian cancer cells

2003 • 59 citations

Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression

2007 • 59 citations

Stimulatory effect of lysophosphatidic acids on uterine smooth muscles of non-pregant rats.

1980 • 59 citations

Effect of lysophosphatidic acid on the preimplantation development of mouse embryos

1994 • 58 citations

Sphingosine-1-Phosphate Metabolism and Intestinal Tumorigenesis: Lipid Signaling Strikes Again

2007 • 58 citations

Production of Lysophosphatidic Acid in Blister Fluid: Involvement of a Lysophospholipase D Activity

2005 • 58 citations

Up-Regulation of p21- and RhoA-Activated Protein Kinases in Human Pregnant Myometrium

2000 • 58 citations

Hen egg yolk and white contain high amounts of lysophosphatidic acids, growth factor‐like lipids: Distinct Molecular species compositions

2001 • 57 citations

Enhancement of the Migration of Metastatic Human Breast Cancer Cells by Phosphatidic Acid

2000 • 57 citations

Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity

2007 • 55 citations

Quantitative Analysis of Lysophosphatidic Acid in Human Blood Fractions

2000 • 54 citations

Sphingosine-1 Phosphate Signaling Regulates Positioning of Dendritic Cells within the Spleen

2007 • 54 citations

FGFR4 GLY388 isotype suppresses motility of MDA-MB-231 breast cancer cells by EDG-2 gene repression

2005 • 54 citations

Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus

2006 • 53 citations

Loss of the Lysophosphatidylcholine Effector, G2A, Ameliorates Aortic Atherosclerosis in Low-Density Lipoprotein Receptor Knockout Mice

2006 • 53 citations

VEGF- and LPA-induced telomerase in human ovarian cancer cells is Sp1-dependent

2007 • 52 citations

Increased Expression of CYR61, an Extracellular Matrix Signaling Protein, in Human Benign Prostatic Hyperplasia and Its Regulation by Lysophosphatidic Acid

2004 • 52 citations

Lysophosphatidic acid promotes survival of androgen‐insensitive prostate cancer PC3 cells via activation of NF‐κB

2004 • 52 citations

Intrauterine Migration of the Porcine Embryo: Influence of Estradiol-17β and Histamine

1982 • 51 citations

Lysophosphatidic Acid Acyltransferase-β Is a Prognostic Marker and Therapeutic Target in Gynecologic Malignancies

2005 • 51 citations

The structure and functions of human lysophosphatidic acid acyltransferases

2001 • 51 citations

Lysophosphatidic acid stimulates PC‐3 prostate cancer cell matrigel invasion through activation of RhoA and NF‐κB activity

2006 • 50 citations

Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission

2000 • 50 citations

Purification and characterization of a lysophospholipase from human amnionic membranes.

1984 • 50 citations

AFAP‐110 is required for actin stress fiber formation and cell adhesion in MDA‐MB‐231 breast cancer cells

2007 • 49 citations

Neurobiology of Receptor‐Mediated Lysophospholipid Signaling: From the First Lysophospholipid Receptor to Roles in Nervous System Function and Development

2000 • 47 citations

Characterization of the Drosophila Sphingosine Kinases and Requirement for Sk2 in Normal Reproductive Function

2004 • 47 citations

FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.

2007 • 46 citations

Myometrial Activity and the Distribution of Blastocysts in the Uterus of the Rat: Interference by Relaxin

1980 • 46 citations

Sphingosine 1-phosphate: synthesis and release.

2001 • 45 citations

Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development

2006 • 44 citations

Lysophosphatidic acid stimulates nuclear and cytoplasmic maturation of golden hamster immature oocytes in vitro via cumulus cells

2002 • 44 citations

The lysophosphatidic acid (LPA) receptors their expression and significance in epithelial ovarian neoplasms

2007 • 44 citations

Lysophosphatidic Acid and Its Role in Reproduction

2002 • 44 citations

Sphingosine-1-Phosphate Receptor Expression and Signaling Correlate with Uterine Prostaglandin-Endoperoxide Synthase 2 Expression and Angiogenesis During Early Pregnancy1

2005 • 43 citations

Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells

1994 • 42 citations

Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?

2007 • 41 citations

Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA1 receptor in Gi-inactivated CHO cells

2006 • 41 citations

The Cross Talk Between Protein Kinase A– and RhoA-Mediated Signaling in Cancer Cells

2005 • 41 citations

Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a Gi-coupled receptor response

2005 • 41 citations

Purification and Properties of a Phospholipase A2/Lipase Preferring Phosphatidic Acid, Bis(monoacylglycerol) Phosphate, and Monoacylglycerol from Rat Testis

2002 • 40 citations

Loss of Spinal Substance P Pain Transmission under the Condition of LPA_I Receptor-Mediated Neuropathic Pain

2006 • 40 citations

Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P.

2006 • 39 citations

Actin polymerization in the equatorial and postacrosomal regions of guinea pig spermatozoa during the acrosome reaction is regulated by G proteins

2004 • 39 citations

Activation of Protein Kinase Cα in the Lysophosphatidic Acid-Induced Bovine Sperm Acrosome Reaction and Phospholipase D1 Regulation1

2000 • 39 citations

Sphingosine-1-Phosphate Acts via Rho-Associated Kinase and Nitric Oxide to Regulate Human Placental Vascular Tone1

2005 • 39 citations

Proline-rich tyrosine kinase 2 regulates proliferation and differentiation of prostate cells

2002 • 39 citations

Potentiation of Rho-A-mediated Lysophosphatidic Acid Activity by Hyperinsulinemia

2000 • 38 citations

Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms

2006 • 38 citations

Effect of lysophosphatidic acid on the ovum transport in mouse oviducts

1999 • 38 citations

Interleukin 6 Mediates the Lysophosphatidic Acid-regulated Cross-talk between Stromal and Epithelial Prostate Cancer Cells

2004 • 37 citations

Two Novel Xenopus Homologs of Mammalian LPA1/EDG-2 Function as Lysophosphatidic Acid Receptors inXenopus Oocytes and Mammalian Cells

2001 • 37 citations

Type 1 Sphingosine 1-Phosphate G Protein-Coupled Receptor (S1P1) Mediation of Enhanced IL-4 Generation by CD4 T Cells from S1P1 Transgenic Mice

2007 • 36 citations

Study of the acrosome reaction and the fertilizing ability of hamster epididymal cauda spermatozoa treated with antibodies against phospholipase A2 and/or lysophosphatidylcholine

1996 • 36 citations

Oxytocin and Lysophosphatidic Acid Induce Stress Fiber Formation in Human Myometrial Cells via a Pathway Involving Rho-Kinase1

2001 • 36 citations

Sphingolipid Signaling Pathways as Potential Therapeutic Targets in Gliomas

2007 • 36 citations

Sphingosine 1-Phosphate Induces Endothelial Nitric-Oxide Synthase Activation through Phosphorylation in Human Corpus Cavernosum

2005 • 35 citations

S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells

2007 • 34 citations

Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway

2007 • 33 citations

Sphingosine-1-Phosphate Inhibits Nuclear Factor κB Activation and Germ Cell Apoptosis in the Human Testis Independently of Its Receptors

2005 • 33 citations

Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences

2006 • 33 citations

Biochemical regulation of breast cancer cell expression of S1P₂ (Edg‐5) and S1P₃ (Edg‐3) G protein‐coupled receptors for sphingosine 1‐phosphate

2002 • 32 citations

Pharmacological Modulation of Sphingolipids and Role in Disease and Cancer Cell Biology

2007 • 32 citations

Lysophosphatidic acid (LPA) promotes E-cadherin ectodomain shedding and OVCA429 cell invasion in an uPA-dependent manner

2008 • 32 citations

S1P regulation of ovarian carcinoma invasiveness

2006 • 32 citations

Translocation of Fas by LPA prevents ovarian cancer cells from anti-Fas-induced apoptosis

2004 • 32 citations

The signaling pathways linking to lysophosphatidic acid-promoted meiotic maturation in mice

2006 • 32 citations

Quantitative expression of lysophosphatidic acid receptor 3 gene in porcine endometrium during the periimplantation period and estrous cycle

2007 • 31 citations

Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces the change of calcium mobilization via TRPC ion channels in cultured human corporal smooth muscle cells

2005 • 31 citations

Function of the Small Guanosine Triphosphate-Binding Protein RhoA in the Process of Implantation¹

2000 • 30 citations

Fluid Shear Stress Differentially Regulates gpr3, gpr6, and gpr12 Expression in Human Umbilical Vein Endothelial Cells

2003 • 30 citations

FTY720: A Most Promising Immunosuppressant Modulating Immune Cell Functions

2007 • 30 citations

Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway.

2007 • 29 citations

Downregulation of mRNA Expression of Edg-3, a Putative Sphingosine 1-Phosphate Receptor Coupled to Ca2+Signaling, during Differentiation of HL-60 Leukemia Cells

1998 • 29 citations

A Rice Dihydrosphingosine C4 Hydroxylase (DSH1) Gene, which is Abundantly Expressed in the Stigmas, Vascular Cells and Apical Meristem, may be Involved in Fertility

2007 • 29 citations

Lysophosphatidic acid signaling controls cortical actin assembly and cytoarchitecture in Xenopus embryos

2005 • 29 citations

Production of bioactive lysophosphatidic acid by lysophospholipase D in hen egg white

2007 • 29 citations

Expression of lysophosphatidic acid acyltransferase beta (LPAAT-β) in ovarian carcinoma: correlation with tumour grading and prognosis

2005 • 28 citations

Maternal and Embryonic Control of Uterine Sphingolipid-Metabolizing Enzymes During Murine Embryo Implantation1

2007 • 28 citations

Involvement of prostaglandins in implantation in the pregnant mouse.

1985 • 27 citations

Combination treatment with FTY720 and CTLA4IgG preserves the respiratory epithelium and prevents obliterative disease in a murine airway model

2002 • 27 citations

Unfolding the Pathophysiological Role of Bioactive Lysophospholipids

2003 • 26 citations

Preterm labor and bacterial intraamniotic infection: Arachidonic acid liberation by phospholipase A2 of Fusobacterium nucleatum

1998 • 25 citations

Endogenous RGS proteins attenuate Gαi-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells

2007 • 25 citations

Lysophospholipid signaling: Beyond the EDGs

2007 • 24 citations

Sphingosine 1-phosphate receptors modulate intracellular Ca2+ homeostasis

2006 • 22 citations

Lysophosphatidic Acid Inhibits Serum Deprivation-Induced Autophagy in Human Prostate Cancer PC-3 Cells

2007 • 22 citations

Biomarkers of ovulation, endometrial receptivity, fertilisation, implantation and early pregnancy progression

2006 • 21 citations

Lysophosphatidic Acid Signals through Mitogen-Activated Protein Kinase-Extracellular Signal Regulated Kinase in Ovarian Theca Cells Expressing the LPA1/edg2-Receptor: Involvement of a Nonclassical Pathway?

2003 • 21 citations

Lysophosphatidic Acid (LPA)-Induced Vascular Endothelial Growth Factor (VEGF) by Mesothelial Cells and Quantification of Host-Derived VEGF in Malignant Ascites

2005 • 21 citations

Lysophosphatidic Acid Antagonizes the Morphoregulatory Effects of the Luteinizing Hormone on Luteal Cells: Possible Role of Small Rho-G-Proteins1

2001 • 21 citations

Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD)

2007 • 20 citations

Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor

2005 • 20 citations

Function of the Small Guanosine Triphosphate-Binding Protein RhoA in the Process of Implantation

2000 • 19 citations

Analysis of the Proliferative Response to Lysophosphatidic Acid in Primary Cultures of Mammary Epithelium: Differences between Normal and Tumor Cells

1995 • 17 citations

Expression of the endothelial cell differentiation gene 7 (EDG‐7), a lysophosphatidic acid receptor, in ovarian tumor

2005 • 17 citations

Different Proliferative Responses of G<sub>i/o</sub>-Protein-Coupled Receptors in Human Myometrial Smooth Muscle Cells: A Possible Role of Calcium

1998 • 17 citations

Modulation of Human Arterial Tone During Pregnancy: The Effect of the Bioactive Metabolite Sphingosine-1-Phosphate1

2007 • 16 citations

Effects of Acid Sphingomyelinase Deficiency on Male Germ Cell Development and Programmed Cell Death1

2004 • 16 citations

Lysophosphatidic acid induces glycodelin gene expression in cancer cells

2002 • 16 citations

Comparative effects of 6-hydroxydopamine and -adrenoceptor antagonists on intrauterine migration and spacing of blastocysts in the rat

1987 • 15 citations

Use of lysophosphatidic acid in the management of benign and malignant ovarian tumors.

2007 • 15 citations

Lysophosphatidic Acid-Induced Nuclear Localization of Protein Kinase C δ in Bovine Theca Cells Stimulated with Luteinizing Hormone1

2002 • 14 citations

Preterm Labor and Bacterial Intra-amniotic Infection: Arachidonic Acid Liberation by Phospholiphase A2ofPrevotella bivia

1998 • 12 citations

Growth factors for therapeutic angiogenesis in hypercholesterolemic erectile dysfunction

2008 • 12 citations

Localization of Sphingosine Kinase-1 in Mouse Sperm Acrosomes

2005 • 11 citations

Inhibition of Ca²⁺/calmodulin‐dependent protein kinase or epidermal growth factor receptor tyrosine kinase abolishes lysophosphatidic acid‐mediated DNA‐synthesis in human myometrial smooth muscle cells

2003 • 10 citations

Cell cycle analysis of Chinese hamster ovary cells stimulated by phosphatidic acid in serum-free culture

2004 • 9 citations

Microarray analysis of gene expression profile in the corpus cavernosum of hypercholesterolemic rats after chronic treatment with PDE5 inhibitor

2006 • 6 citations

Expression and significance of Edg4 and Edg7 in the placentas of patients with hypertensive disorder complicating pregnancy

2007 • 5 citations