Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

2005 • 772 citations

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

2003 • 523 citations

FTY720: Sphingosine 1-Phosphate Receptor-1 in the Control of Lymphocyte Egress and Endothelial Barrier Function

2004 • 462 citations

Sphingosine 1-Phosphate, a Bioactive Sphingolipid Abundantly Stored in Platelets, Is a Normal Constituent of Human Plasma and Serum

1997 • 442 citations

Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases

2003 • 427 citations

Erythrocytes store and release sphingosine 1‐phosphate in blood

2007 • 355 citations

Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver.

1992 • 343 citations

Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells

2000 • 210 citations

Sphingosine 1-Phosphate Induces Platelet Activation through an Extracellular Action and Shares a Platelet Surface Receptor with Lysophosphatidic Acid

1997 • 200 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2

2003 • 172 citations

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate

2007 • 170 citations

Identification of the First Mammalian Sphingosine Phosphate Lyase Gene and Its Functional Expression in Yeast

1998 • 168 citations

Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner

2005 • 157 citations

Cloning and Characterization of Two Human Isozymes of Mg2+-independent Phosphatidic Acid Phosphatase

1997 • 157 citations

Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5′-phosphate binding domain exposed to the cytosol

2004 • 150 citations

Simultaneous Quantitative Analysis of Sphingoid Base 1-Phosphates in Biological Samples by o-Phthalaldehyde Precolumn Derivatization after Dephosphorylation with Alkaline Phosphatase

2002 • 149 citations

Sphingosine-phosphate Lyase Enhances Stress-induced Ceramide Generation and Apoptosis

2004 • 147 citations

Structural organization of mammalian lipid phosphate phosphatases: implications for signal transduction

1999 • 131 citations

Metabolism and functional effects of sphingolipids in blood cells

1999 • 116 citations

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets

2005 • 111 citations

Identification and cDNA Cloning of 35-kDa Phosphatidic Acid Phosphatase (Type 2) Bound to Plasma Membranes

1996 • 109 citations

G-protein-coupled Receptor Stimulation of the p42/p44 Mitogen-activated Protein Kinase Pathway Is Attenuated by Lipid Phosphate Phosphatases 1, 1a, and 2 in Human Embryonic Kidney 293 Cells

2001 • 94 citations

Purification and Characterization of a Neutral Ceramidase from Mouse Liver

2000 • 92 citations

Metabolism and functional effects of sphingolipids in blood cells

1999 • 90 citations

Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets

2003 • 83 citations

Sphingosine-1-phosphate Lyase Is Involved in the Differentiation of F9 Embryonal Carcinoma Cells to Primitive Endoderm

2003 • 75 citations