AFAP‐110 is required for actin stress fiber formation and cell adhesion in MDA‐MB‐231 breast cancer cells

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Rho GTPases and the Actin Cytoskeleton

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FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Bidirectional signaling between the cytoskeleton and integrins

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Electric Cell–Substrate Impedance Sensing (ECIS) as a Noninvasive Means to Monitor the Kinetics of Cell Spreading to Artificial Surfaces

2000 • 743 citations

Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again

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1994 • 469 citations

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

1997 • 401 citations

Exploring the Neighborhood

2002 • 398 citations

Rho as a regulator of the cytoskeleton

1995 • 386 citations

Protein kinase C involvement in focal adhesion formation

1992 • 361 citations

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.

1995 • 324 citations

Microfilament Structure and Function in the Cortical Cytoskeleton

1991 • 276 citations

The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.

1991 • 224 citations

Are stress fibres contractile?

1981 • 224 citations

Stable Association of Activated pp60^src with Two Tyrosine-Phosphorylated Cellular Proteins

1989 • 168 citations

The role of the cortical cytoskeleton: F-actin crosslinking proteins protect against osmotic stress, ensure cell size, cell shape and motility, and contribute to phagocytosis and development

1996 • 161 citations

Redundancy in the microfilament system: Abnormal development of dictyostelium cells lacking two F-actin cross-linking proteins

1992 • 151 citations

Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

2006 • 127 citations

Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate.

1993 • 125 citations

Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins.

1989 • 100 citations

Protein Kinase Cα Activates c-Src and Induces Podosome Formation via AFAP-110

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Dissection of Pathways Implicated in Integrin-mediated Actin Cytoskeleton Assembly

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Signaling, mitogenesis and the cytoskeleton: Where the action is

1995 • 76 citations

Focal Adhesion Kinase Regulates Metastatic Adhesion of Carcinoma Cells within Liver Sinusoids

2005 • 70 citations

Three actin cross-linking proteins, the 34 kDa actin-bundling protein, α-actinin and gelation factor (ABP-120), have both unique and redundant roles in the growth and development of Dictyostelium

1999 • 68 citations

Functional Synergy of Actin Filament Cross-linking Proteins

2002 • 63 citations

The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity

2001 • 62 citations

Different adhesion properties of highly and poorly metastatic HT-29 colon carcinoma cells with extracellular matrix components: role of integrin expression and cytoskeletal components

1999 • 60 citations

Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity

1998 • 50 citations

The Carboxy Terminus of AFAP-110 Modulates Direct Interactions with Actin Filaments and Regulates Its Ability to Alter Actin Filament Integrity and Induce Lamellipodia Formation

2000 • 48 citations

The integrity of the SH3 binding motif of AFAP-110 is required to facilitate tyrosine phosphorylation by, and stable complex formation with, Src.

1997 • 48 citations

The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases

2001 • 46 citations

Dictyostelium discoideum cells lacking the 34,000-dalton actin-binding protein can grow, locomote, and develop, but exhibit defects in regulation of cell structure and movement: a case of partial redundancy.

1996 • 46 citations

PKC Phosphorylation Increases the Ability of AFAP-110 to Cross-link Actin Filaments

2002 • 44 citations

Paxillin modulates squamous cancer cell adhesion and is important in pressure‐augmented adhesion

2006 • 34 citations

Breast adenocarcinoma cell adhesion to the vascular subendothelium in whole blood and under flow conditions: Effects of α v β 3 and α IIb β 3 antagonists

2004 • 33 citations

Formation of a stable src–AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif

1998 • 30 citations

Drosophila fascin mutants are rescued by overexpression of the villin-like protein, quail

1998 • 28 citations

Analysis of the role of the leucine zipper motif in regulating the ability of AFAP‐110 to alter actin filament integrity

2003 • 23 citations

Intracellular Trafficking and the Cytoskeleton

2006 • 1 citations