Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine 1-Phosphate Generation in Blood

Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules

1999 • 1,379 citations

Techniques of Lipidology

1973 • 777 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Sphingosine 1-Phosphate, a Bioactive Sphingolipid Abundantly Stored in Platelets, Is a Normal Constituent of Human Plasma and Serum

1997 • 442 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Blood lipids and lipoproteins; quantitation, composition and metabolism

1973 • 400 citations

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions

2000 • 393 citations

Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

1981 • 368 citations

Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

1992 • 355 citations

Lipid composition of human serum lipoproteins

1967 • 295 citations

Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin

1979 • 285 citations

Extracellular Export of Sphingosine Kinase-1 Enzyme

2002 • 281 citations

Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species

2000 • 255 citations

Characterization of plasma unsaturated lysophosphatidylcholines in human and rat

1999 • 233 citations

Direct Quantitative Analysis of Lysophosphatidic Acid Molecular Species by Stable Isotope Dilution Electrospray Ionization Liquid Chromatography–Mass Spectrometry

2001 • 232 citations

The phosphatidylinositol cycle and the regulation of arachidonic acid production

1981 • 230 citations

The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid.

1981 • 228 citations

Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells

2000 • 210 citations

Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids

2001 • 191 citations

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin

1989 • 185 citations

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

1996 • 173 citations

Phosphatidic and lysophosphatidic acid production in phospholipase C-and thrombin-treated platelets. possible involvement of a platelet lipase

1978 • 166 citations

Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma

1986 • 165 citations

Transport of lysolecithin by albumin in human and rat plasma

1965 • 158 citations

Elevated levels and altered fatty acid composition of plasma lysophosphatidlycholine(lysoPC) in ovarian cancer patients

1997 • 148 citations

The binding of lysophospholipids to rat liver fatty acid-binding protein and albumin

1994 • 137 citations

Gelsolin Binding and Cellular Presentation of Lysophosphatidic Acid

2000 • 128 citations

Quantitative Measurement of Sphingosine 1-Phosphate in Biological Samples by Acylation with Radioactive Acetic Anhydride

1995 • 118 citations

The molecular species composition of individual diacyl phospholipids in human platelets

1982 • 117 citations

Molecular species of glycerophospholipids and sphingomyelins of human plasma: Comparison to red blood cells

1989 • 115 citations

Changes in ³²P‐Content of Phosphatidic Acid and the Phosphoinositides of Rabbit Platelets during Aggregation Induced by Collagen or Thrombin

1974 • 101 citations

Physiological responses to lysophosphatidic acid and related glycero-phospholipids

2001 • 93 citations

A Novel Phospholipase A1 with Sequence Homology to a Mammalian Sec23p-interacting Protein, p125

2002 • 89 citations

Identification of a phosphatidic acid-preferring phospholipase A1 from bovine brain and testis.

1994 • 83 citations

Changes in³²P-Labelling of Platelet Phospholipids in Response to ADP

1972 • 80 citations

Metal‐lon stimulation and inhibition of lysophospholipase D which generates bioactive lysophosphatidic acid in rat plasma

1998 • 51 citations

Lysophosphatidic acid potentiates the thrombin-induced production of arachidonate metabolites in platelets.

1981 • 50 citations

Conversion of Lysophospholipids to Cyclic Lysophosphatidic Acid by Phospholipase D

1996 • 50 citations

Two Novel Xenopus Homologs of Mammalian LPA1/EDG-2 Function as Lysophosphatidic Acid Receptors inXenopus Oocytes and Mammalian Cells

2001 • 37 citations

A Fluorescent Assay for Agonist-Activated Phospholipase D in Mammalian Cell Extracts

1994 • 31 citations

Membrane sidedness of biosynthetic pathways involved in the production of lysophosphatidic acid

1999 • 30 citations

Lysophosphatidic acid can activate platelets without increasing 32P-labelling of phosphatidic acid

1984 • 30 citations

1‐Acyl‐2‐lysophosphatidylcholine transport across the blood—retina and blood—brain barrier

1994 • 13 citations