Athero- and thrombogenic actions of lysophosphatidic acid and sphingosine-1-phosphate

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Atherosclerosis: Basic Mechanisms

1995 • 1,697 citations

Atherosclerosis and the Arterial Smooth Muscle Cell

1973 • 1,503 citations

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1996 • 1,493 citations

Edg-1, the G protein–coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

2000 • 1,138 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

The Intima

1995 • 984 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 830 citations

Lewis A. Conner Memorial Lecture

1997 • 754 citations

Comparative genomes of Chlamydia pneumoniae and C. trachomatis

1999 • 687 citations

Oxidized LDL and Malondialdehyde-Modified LDL in Patients With Acute Coronary Syndromes and Stable Coronary Artery Disease

1998 • 681 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Molecular mechanisms in intimal hyperplasia

2000 • 558 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

Rho and Rac but not Cdc42 regulate endothelial cell permeability

2001 • 462 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

Endothelial Cell Apoptosis in Angiogenesis and Vessel Regression

2000 • 412 citations

Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions

2000 • 393 citations

Endothelial function and coronary artery disease

2001 • 381 citations

Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor

1999 • 371 citations

Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

1981 • 368 citations

Sphingosine 1-Phosphate Induces Angiogenesis: Its Angiogenic Action and Signaling Mechanism in Human Umbilical Vein Endothelial Cells

1999 • 359 citations

Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase–mediated Myosin Light Chain Phosphorylation in Mouse Platelets

1999 • 359 citations

Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

1992 • 355 citations

Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3

2000 • 328 citations

Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms

2001 • 300 citations

Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins

2001 • 284 citations

Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis

2000 • 276 citations

Sphingosine 1-Phosphate Activates Akt, Nitric Oxide Production, and Chemotaxis through a GiProtein/Phosphoinositide 3-Kinase Pathway in Endothelial Cells

2001 • 268 citations

Transient and Prolonged Increase in Endothelial Permeability Induced by Histamine and Thrombin

1998 • 266 citations

Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes

1998 • 265 citations

Sphingosine 1-Phosphate May Be a Major Component of Plasma Lipoproteins Responsible for the Cytoprotective Actions in Human Umbilical Vein Endothelial Cells

2001 • 265 citations

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.

1995 • 264 citations

Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species

2000 • 255 citations

Sphingosine 1-Phosphate and Activation of Endothelial Nitric-oxide Synthase

2001 • 241 citations

Direct Quantitative Analysis of Lysophosphatidic Acid Molecular Species by Stable Isotope Dilution Electrospray Ionization Liquid Chromatography–Mass Spectrometry

2001 • 232 citations

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

2000 • 231 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

Phospholipase A ₂ in Vascular Disease

2001 • 223 citations

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

1998 • 223 citations

Lysophosphatidic Acid and Sphingosine 1-Phosphate Protection of T Cells from Apoptosis in Association with Suppression of Bax

1999 • 219 citations

Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells

2000 • 210 citations

Sphingosine‐1‐Phosphate in Cell Growth and Cell Death^a

1998 • 202 citations

Sphingosine 1-Phosphate Protects Human Umbilical Vein Endothelial Cells from Serum-deprived Apoptosis by Nitric Oxide Production

2001 • 201 citations

Sphingosine 1-Phosphate Induces Platelet Activation through an Extracellular Action and Shares a Platelet Surface Receptor with Lysophosphatidic Acid

1997 • 200 citations

Phenotypic Modulation of Vascular Smooth Muscle Cells Induced by Unsaturated Lysophosphatidic Acids

2001 • 191 citations

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin

1989 • 185 citations

Current Perspective on the Role of Apoptosis in Atherothrombotic Disease

2001 • 182 citations

Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6

2000 • 174 citations

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

1997 • 172 citations

LDL- is a lipid hydroperoxide-enriched circulating lipoprotein

1997 • 170 citations

Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis

1997 • 169 citations

Phosphatidic and lysophosphatidic acid production in phospholipase C-and thrombin-treated platelets. possible involvement of a platelet lipase

1978 • 166 citations

Role of the Sphingosine 1-Phosphate Receptor EDG-1 in Vascular Smooth Muscle Cell Proliferation and Migration

2001 • 166 citations

Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma

1986 • 165 citations

Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists

2001 • 163 citations

Agonist-modulated Targeting of the EDG-1 Receptor to Plasmalemmal Caveolae

2000 • 159 citations

Dichotomous Regulation of Myosin Phosphorylation and Shape Change by Rho-Kinase and Calcium in Intact Human Platelets

1999 • 158 citations

Role of Sphingosine 1-Phosphate in the Mitogenesis Induced by Oxidized Low Density Lipoprotein in Smooth Muscle Cells via Activation of Sphingomyelinase, Ceramidase, and Sphingosine Kinase

1999 • 157 citations

Apoptosis in the vascular wall and atherosclerosis

2001 • 155 citations

Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors.

2001 • 153 citations

Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway.

1998 • 152 citations

Differential Regulation of Sphingosine-1-Phosphate- and VEGF-Induced Endothelial Cell Chemotaxis

2001 • 144 citations

Sphingosine 1-phosphate receptors

2001 • 139 citations

Lysophosphatidic Acid-induced Mitogenesis Is Regulated by Lipid Phosphate Phosphatases and Is Edg-receptor Independent

2001 • 136 citations

Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction.

1999 • 133 citations

Secretory group II phospholipase A2 in human atherosclerotic plaques

1995 • 131 citations

Gelsolin Binding and Cellular Presentation of Lysophosphatidic Acid

2000 • 128 citations

The LPA receptors

2001 • 121 citations

Lysophosphatidic acid prevents apoptosis in fibroblasts via Gi-protein-mediated activation of mitogen-activated protein kinase

2000 • 121 citations

Mildly Oxidized Low Density Lipoprotein Induces Contraction of Human Endothelial Cells through Activation of Rho/Rho Kinase and Inhibition of Myosin Light Chain Phosphatase

1999 • 120 citations

Quantitative Measurement of Sphingosine 1-Phosphate in Biological Samples by Acylation with Radioactive Acetic Anhydride

1995 • 118 citations

Metabolism and functional effects of sphingolipids in blood cells

1999 • 116 citations

Apoptosis as a Determinant of Atherothrombosis

2001 • 113 citations

Sphingosine-1-Phosphate and Lysophosphatidic Acid Stimulate Endothelial Cell Migration

2000 • 103 citations

A High-Performance Liquid Chromatographic Method to Measure Sphingosine 1-Phosphate and Related Compounds from Sphingosine Kinase Assays and Other Biological Samples

2000 • 103 citations

Sphingosine‐1‐phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro

2000 • 103 citations

Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells

2000 • 101 citations

Phosphatidic Acid and Lysophosphatidic Acid Induce Haptotactic Migration of Human Monocytes

1995 • 100 citations

Lysophosphatidic Acid Receptor-Selective Effects on Jurkat T Cell Migration Through a Matrigel Model Basement Membrane

2001 • 96 citations

Endothelial cell mitogenesis induced by LPA: Inhibition by thrombospondin-1 and thrombospondin-2

1997 • 96 citations

Physiological responses to lysophosphatidic acid and related glycero-phospholipids

2001 • 93 citations

Cutting Edge: Differential Constitutive Expression of Functional Receptors for Lysophosphatidic Acid by Human Blood Lymphocytes

2000 • 91 citations

High specificity of human secretory class II phospholipase A2 for phosphatidic acid

1997 • 90 citations

Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: A new group of phospholipid mediators?

1982 • 89 citations

Mildly Oxidized Low Density Lipoprotein Rapidly Stimulates via Activation of the Lysophosphatidic Acid Receptor Src Family and Syk Tyrosine Kinases and Ca2+ Influx in Human Platelets

2000 • 87 citations

A simple and highly sensitive radioenzymatic assay for lysophosphatidic acid quantification

2000 • 86 citations

Exogenous Oxidized Low-Density Lipoprotein Injures and Alters the Barrier Function of Endothelium in Rats In Vivo

1997 • 85 citations

Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets?

1982 • 84 citations

Biochemical Characterization of the Interaction of Lipid Phosphoric Acids with Human Platelets: Comparison with Platelet Activating Factor

1994 • 81 citations

Evidence That Lipoproteins Are Carriers of Bioactive Factors

1999 • 78 citations

Altered expression and functional profile of lysophosphatidic acid receptors in mitogen‐activated human blood T lymphocytes

2000 • 78 citations

Regulatory Role of Ceramide in Interleukin (IL)-1β-induced E-selectin Expression in Human Umbilical Vein Endothelial Cells

1996 • 77 citations

Structure−Activity Analysis of the Effects of Lysophosphatidic Acid on Platelet Aggregation

1999 • 76 citations

The Mouse Gene for the Inducible G-Protein-Coupled Receptoredg-1

1997 • 75 citations

An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials

2001 • 70 citations

Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator

2001 • 67 citations

Lysophosphatidic Acid Activates Nuclear Factor Kappa B and Induces Proinflammatory Gene Expression in Endothelial Cells

1999 • 66 citations

A factor that activates oscillatory chloride currents in Xenopus oocytes copurifies with a subfraction of serum albumin.

1991 • 65 citations

Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1‐phosphate

2000 • 61 citations

Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells

1996 • 58 citations

Lysophosphatidic acid-induced platelet shape change proceeds via Rho/Rho kinase-mediated myosin light-chain and moesin phosphorylation

2000 • 58 citations

N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors.

1996 • 57 citations

Lysophosphatidic acid: receptors, signaling and survival

2000 • 52 citations

Identification of a Novel Growth Factor-like Lipid, 1-O-cis-Alk-1′-enyl-2-lyso-sn-glycero-3-phosphate (Alkenyl-GP) That Is Present in Commercial Sphingolipid Preparations

1998 • 50 citations

Sphingosine 1-Phosphate Stimulates Gi- and Rho-Mediated Vascular Endothelial Cell Spreading and Migration

2000 • 44 citations

Mildly oxidised low density lipoprotein induces platelet shape change via Rho‐kinase‐dependent phosphorylation of myosin light chain and moesin

2000 • 43 citations

Effects of Lysophosphatidic Acid on Proliferation and Cytosolic Ca++ of Human Adult Vascular Smooth Muscle Cells in Culture

1999 • 43 citations

Platelet aggregation induced by ether-linked phospholipids. 1. inhibitory actions of bovine serum albumin and structural analogues of platelet activating factor

1987 • 42 citations

Lysophosphatidic acid and intracellular signalling in vascular smooth muscle cells

1997 • 41 citations

Stimulation of Platelets and Endothelial Cells by Mildly Oxidized LDL Proceeds through Activation of Lysophosphatidic Acid Receptors and the Rho/Rho‐Kinase Pathway: Inhibition by Lovastatin

2000 • 41 citations

Minimal oxidation and storage of low density lipoproteins result in an increased susceptibility to phospholipid hydrolysis by phospholipase A2

1997 • 39 citations

Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate

2001 • 37 citations

Substrate specificity of lysophospholipase D which produces bioactive lysophosphatidic acids in rat plasma

1999 • 33 citations

Genetic and Pharmacological Analyses of Involvement of Src-family, Syk and Btk Tyrosine Kinases in Platelet Shape Change

2001 • 33 citations

Lysophosphatidic Acids Induce Contraction of Rat Isolated Colon by Two Different Mechanisms

1991 • 32 citations

Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids

1996 • 30 citations

Membrane sidedness of biosynthetic pathways involved in the production of lysophosphatidic acid

1999 • 30 citations

Lysophosphatidic acid can activate platelets without increasing 32P-labelling of phosphatidic acid

1984 • 30 citations

Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management

2001 • 28 citations

Lysophosphatidic acid promotes phorbol-ester-induced apoptosis in TF-1 cells by interfering with adhesion

2001 • 28 citations

Lysophosphatidic Acid Positively Regulates the Fluid Flow–Induced Local Ca ²⁺ Influx in Bovine Aortic Endothelial Cells

2001 • 28 citations

Vasopressor effect of lysophosphatidic acid on spontaneously hypertensive rats and Wistar Kyoto rats.

1995 • 27 citations

Lysophosphatidic Acid and Sphingosine 1‐Phosphate: Two Lipid Villains Provoking Cardiovascular Diseases?

2000 • 22 citations

Upregulation of endothelin-1 production by lysophosphatidic acid in rat aortic endothelial cells

1998 • 18 citations

Dual effects of lysophosphatidic acid on human airway smooth muscle cell proliferation and survival

2001 • 15 citations

The formation of [3H]inositol phosphates in human platelets by palmitoyl lysophosphatidic acid is blocked by indomethacin

1985 • 14 citations

Lysophospholipid‐Induced Cell Migration

2000 • 14 citations