Lysophosphatidic Acid and Its Role in Reproduction

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Lysophosphatidic Acid as a Potential Biomarker for Ovarian and Other Gynecologic Cancers

1998 • 642 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

Requirement for the lp _A1 lysophosphatidic acid receptor gene in normal suckling behavior

2000 • 468 citations

Bioactive Lysophospholipids and Their G Protein-Coupled Receptors

1999 • 412 citations

Lysophosphatidic Acid Receptors

2000 • 404 citations

Receptors for a growing family of secreted phospholipases A2

1999 • 396 citations

Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.

1995 • 325 citations

Lysophospholipids activate ovarian and breast cancer cells

1995 • 289 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

Mammalian Lipid Phosphate Phosphohydrolases

1998 • 253 citations

Lysophospholipid Growth Factors in the Initiation, Progression, Metastases, and Management of Ovarian Cancer

2000 • 243 citations

Lysophosphatidic acid signalling

1995 • 223 citations

Molecular Cloning and Characterization of a Lysophosphatidic Acid Receptor, Edg-7, Expressed in Prostate

2000 • 206 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

Malignant effusions contain lysophosphatidic acid (LPA)-like activity

1998 • 178 citations

Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2.

2000 • 172 citations

Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis

1997 • 169 citations

Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.

1999 • 166 citations

Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma

1986 • 165 citations

Evaluation of Plasma Lysophospholipids for Diagnostic Significance Using Electrospray Ionization Mass Spectrometry (ESI‐MS) Analyses

2000 • 159 citations

Regulation of Astrocyte Morphology by RhoA and Lysophosphatidic Acid

1998 • 153 citations

A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs)

1999 • 153 citations

Development of Our Current Understanding of Bioactive Lysophospholipids

2000 • 151 citations

Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.

1999 • 147 citations

Lysophosphatidic Acid-induced Mitogenesis Is Regulated by Lipid Phosphate Phosphatases and Is Edg-receptor Independent

2001 • 136 citations

Production of Lysophosphatidic Acids by Lysophospholipase D in Human Follicular Fluids of In Vitro Fertilization Patients1

1999 • 128 citations

Phorbol 12-Myristate 13-Acetate Stimulates Lysophosphatidic Acid Secretion from Ovarian and Cervical Cancer Cells but Not from Breast or Leukemia Cells

1998 • 113 citations

Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.

1999 • 110 citations

Inhibition of Rho Is Required for cAMP-induced Melanoma Cell Differentiation

1998 • 101 citations

Phospholipase A2 activation and subsequent exocytosis in the Ca2+/ionophore-induced acrosome reaction of ram spermatozoa

1993 • 84 citations

Exogenous phospholipase D generates Iysophosphatidic acid and activates Ras, Rho and Ca2+ signaling pathways

1998 • 84 citations

Genomic Characterization of the Lysophosphatidic Acid Receptor Gene, lpA2/Edg4, and Identification of a Frameshift Mutation in a Previously Characterized cDNA

2000 • 83 citations

Induction of stable microtubules in 3T3 fibroblasts by TGF-β and serum

1994 • 75 citations

MITOGENIC SIGNALING IN ANDROGEN SENSITIVE AND INSENSITIVE PROSTATE CANCER CELL LINES

2000 • 71 citations

ESSENTIAL ROLE FOR G PROTEINS IN PROSTATE CANCER CELL GROWTH AND SIGNALING

2000 • 63 citations

Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells

1998 • 63 citations

Purification of a phosphatidic-acid-hydrolysing phospholipase A2 from rat brain

1995 • 62 citations

Complete cDNA Sequence, Genomic Structure, and Chromosomal Localization of the LPA Receptor Gene,lpA1/vzg-1/Gpcr26

1998 • 61 citations

Purification and Properties of a Phosphatidic Acid-preferring Phospholipase A1 from Bovine Testis

1996 • 60 citations

Role of phospholipases during sperm acrosomal exocytosis

1998 • 55 citations

The Role and Clinical Applications of Bioactive Lysolipids in Ovarian Cancer

2001 • 55 citations

Quantitative Analysis of Lysophosphatidic Acid in Human Blood Fractions

2000 • 54 citations

Mechanisms of Lysolipid Phosphate Effects on Cellular Survival and Proliferation

2000 • 52 citations

A Gonadotropin-Releasing Hormone-Responsive Phosphatase Hydrolyses Lysophosphatidic Acid within the Plasma Membrane of Ovarian Cancer Cells

2000 • 50 citations

Activation of Protein Kinase Cα in the Lysophosphatidic Acid-Induced Bovine Sperm Acrosome Reaction and Phospholipase D1 Regulation1

2000 • 39 citations

Effect of lysophosphatidic acid on the ovum transport in mouse oviducts

1999 • 38 citations

Oxytocin and Lysophosphatidic Acid Induce Stress Fiber Formation in Human Myometrial Cells via a Pathway Involving Rho-Kinase1

2001 • 36 citations

Contribution of type II phospholipase A2 to in vitro phospholipase A2 enzymatic activity in human term placenta

1998 • 35 citations

Lysophosphatidic Acids Produced by Lysophospholipase D in Mammalian Serum and Body Fluid

2000 • 34 citations

Membrane sidedness of biosynthetic pathways involved in the production of lysophosphatidic acid

1999 • 30 citations

Function of the Small Guanosine Triphosphate-Binding Protein RhoA in the Process of Implantation¹

2000 • 30 citations

Depletion of lysophosphatidic acid triggers a loss of oriented detyrosinated microtubules in motile fibroblasts

1996 • 30 citations

Phospholipases A2 in the reproductive system of the bull

1991 • 26 citations

The phospholipase A2 of human spermatozoa; purification and partial sequence

1992 • 25 citations

Changes in annexin (lipocortin) content in human amnion and chorion at parturition

1992 • 23 citations

Purification and characterization of a lysophosphatidic acid-specific phosphatase

1998 • 23 citations

The role and clinical applications of bioactive lysolipids in ovarian cancer

2001 • 21 citations

Lysophosphatidic Acid Antagonizes the Morphoregulatory Effects of the Luteinizing Hormone on Luteal Cells: Possible Role of Small Rho-G-Proteins1

2001 • 21 citations

Prostaglandins Mediate the Stimulation of Deoxyribonucleic Acid Synthesis by Transforming Growth Factor α in Hen Granulosa Cells during Ovarian Follicular Development1

1995 • 20 citations

Functional lysophosphatidic acid receptor in bovine luteal cells¹

1997 • 17 citations

The Molecular Pharmacology of Lysophosphatidate Signaling

2000 • 14 citations

Insulin-like growth factor I affects the intraovarian interleukin-1 system: evidence for suppression of type I interleukin-1 receptor expression and enhancement of secretory phospholipase A2 expression and activity

1997 • 11 citations

Phospholipase D treatment enhances gonadotrophin receptor‐coupled adenylate cyclase activity in isolated bovine luteal cells

1993 • 9 citations

Purification and characterization of phospholipase A₂ from bovine prostate

1992 • 6 citations